H
Hiroaki Shimokawa
Researcher at Tohoku University
Publications - 976
Citations - 56856
Hiroaki Shimokawa is an academic researcher from Tohoku University. The author has contributed to research in topics: Heart failure & Endothelium. The author has an hindex of 111, co-authored 949 publications receiving 48822 citations. Previous affiliations of Hiroaki Shimokawa include University of Nebraska Medical Center & Nagoya University.
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Role of Rho-kinase in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in pigs in vivo.
Takashi Shiroto,Satoshi Yasuda,Ryuji Tsuburaya,Yoshitaka Ito,Jun Takahashi,Kenta Ito,Hatsue Ishibashi-Ueda,Hiroaki Shimokawa +7 more
TL;DR: The results suggest that the Rho-kinase pathway plays an important role in the pathogenesis of DES-induced coronary hyperconstricting responses.
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Low-Intensity Pulsed Ultrasound Enhances Angiogenesis and Ameliorates Left Ventricular Dysfunction in a Mouse Model of Acute Myocardial Infarction
Tomohiko Shindo,Kenta Ito,Tsuyoshi Ogata,Kazuaki Hatanaka,Ryo Kurosawa,Kumiko Eguchi,Yuta Kagaya,Kenichiro Hanawa,Kentaro Aizawa,Takashi Shiroto,Sachie Kasukabe,Satoshi Miyata,Hirofumi Taki,Hideyuki Hasegawa,Hiroshi Kanai,Hiroaki Shimokawa +15 more
TL;DR: The results indicate that the LIPUS therapy ameliorates post–myocardial infarction LV remodeling in mice in vivo, for which mechanotransduction and its downstream pathways may be involved.
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Development of collateral function with repetitive coronary occlusion in a canine model reduces myocardial reactive hyperemia in the absence of significant coronary stenosis.
TL;DR: The augmentation of collateral function after repetitive coronary occlusion reduces reactive hyperemia even in the absence of significant coronary stenosis, and debt repayment ratio decreased initially and correlated well with the recovery of regional dysfunction during coronary Occlusion.
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Extracorporeal shock wave therapy induces therapeutic lymphangiogenesis in a rat model of secondary lymphoedema.
TL;DR: The low-energy SW therapy induces therapeutic lymphangiogenesis by up-regulating VEGF-C and bFGF, and improves lymphoedema in a rat-tail model, suggesting that low- energy SW therapy could be a non-invasive and effective strategy for lymphoingema in humans.
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Extracorporeal Low-Energy Shock-Wave Therapy Exerts Anti-Inflammatory Effects in a Rat Model of Acute Myocardial Infarction
Yuzuru Abe,Kenta Ito,Kiyotaka Hao,Tomohiko Shindo,Tsuyoshi Ogata,Yutaka Kagaya,Ryo Kurosawa,Kensuke Nishimiya,Kimio Satoh,Satoshi Miyata,Kazuyoshi Kawakami,Hiroaki Shimokawa +11 more
TL;DR: It is suggested that low-energy SW therapy suppressed post-MI LV remodeling in rats in vivo, which was associated with anti-inflammatory effects in addition to its angiogenic effects, and demonstrated a novel aspect of the therapy for AMI.