K
Katherine A. Siminovitch
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 201
Citations - 18546
Katherine A. Siminovitch is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Genome-wide association study & Protein tyrosine phosphatase. The author has an hindex of 69, co-authored 191 publications receiving 17018 citations. Previous affiliations of Katherine A. Siminovitch include Karolinska Institutet & University of Toronto.
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Journal ArticleDOI
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada,Yukinori Okada,Di Wu,Di Wu,Di Wu,Gosia Trynka,Gosia Trynka,Towfique Raj,Towfique Raj,Chikashi Terao,Katsunori Ikari,Yuta Kochi,Koichiro Ohmura,Akari Suzuki,Shinji Yoshida,Robert R. Graham,A. Manoharan,Ward Ortmann,Tushar Bhangale,Joshua C. Denny,Robert J. Carroll,Anne E. Eyler,Jeff Greenberg,Joel M. Kremer,Dimitrios A. Pappas,Lei Jiang,Jian Yin,Lingying Ye,Ding Feng Su,Jian Yang,Gang Xie,E.C. Keystone,Harm-Jan Westra,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andres Metspalu,Xuezhong Zhou,Namrata Gupta,Daniel B. Mirel,Eli A. Stahl,Dorothee Diogo,Dorothee Diogo,Jing Cui,Jing Cui,Katherine P. Liao,Katherine P. Liao,Michael H. Guo,Michael H. Guo,Keiko Myouzen,Takahisa Kawaguchi,Marieke J H Coenen,Piet L. C. M. van Riel,Mart A F J van de Laar,Henk-Jan Guchelaar,Tom W J Huizinga,Philippe Dieudé,Xavier Mariette,S. Louis Bridges,Alexandra Zhernakova,Alexandra Zhernakova,René E. M. Toes,Paul P. Tak,Paul P. Tak,Paul P. Tak,Corinne Miceli-Richard,So Young Bang,Hye Soon Lee,Javier Martin,Miguel A. Gonzalez-Gay,Luis Rodriguez-Rodriguez,Solbritt Rantapää-Dahlqvist,Lisbeth Ärlestig,Hyon K. Choi,Hyon K. Choi,Yoichiro Kamatani,Pilar Galan,Mark Lathrop,Steve Eyre,Steve Eyre,John Bowes,John Bowes,Anne Barton,Niek de Vries,Larry W. Moreland,Lindsey A. Criswell,Elizabeth W. Karlson,Atsuo Taniguchi,Ryo Yamada,Michiaki Kubo,Jun Liu,Sang Cheol Bae,Jane Worthington,Jane Worthington,Leonid Padyukov,Lars Klareskog,Peter K. Gregersen,Soumya Raychaudhuri,Soumya Raychaudhuri,Barbara E. Stranger,Philip L. De Jager,Philip L. De Jager,Lude Franke,Peter M. Visscher,Matthew A. Brown,Hisashi Yamanaka,Tsuneyo Mimori,Atsushi Takahashi,Huji Xu,Timothy W. Behrens,Katherine A. Siminovitch,Shigeki Momohara,Fumihiko Matsuda,Kazuhiko Yamamoto,Robert M. Plenge,Robert M. Plenge +115 more
TL;DR: A genome-wide association study meta-analysis in a total of >100,000 subjects of European and Asian ancestries provides empirical evidence that the genetics of RA can provide important information for drug discovery, and sheds light on fundamental genes, pathways and cell types that contribute to RA pathogenesis.
Journal ArticleDOI
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease.
John D. Rioux,Mark J. Daly,Mark S. Silverberg,Kerstin Lindblad,Hillary Steinhart,Zane Cohen,Terrye Delmonte,Kerry Kocher,Katie Miller,Sheila Guschwan,Edward J. Kulbokas,Sinéad B. O'Leary,Ellen Winchester,Ken Dewar,Todd Green,Valerie Stone,Christine S. Chow,Albert Cohen,Diane Langelier,Gilles Lapointe,Daniel Gaudet,Janet Faith,Nancy Branco,Shelley B. Bull,Robin S. McLeod,Anne M. Griffiths,Alain Bitton,Gordon R. Greenberg,Eric S. Lander,Katherine A. Siminovitch,Thomas J. Hudson,Thomas J. Hudson +31 more
TL;DR: This work seeks to design a systematic approach for LD mapping and applies it to the localization of a gene (IBD5) conferring susceptibility to Crohn disease, and binds the region to a common haplotype that shows strong association with the disease and contains the cytokine gene cluster.
Journal ArticleDOI
Functional variants of OCTN cation transporter genes are associated with Crohn disease.
Vanya Peltekova,Richard F. Wintle,Laurence A. Rubin,Laurence A. Rubin,Christopher I. Amos,Qiqing Huang,Xiangjun Gu,Bill Newman,Mark Van Oene,David W. Cescon,Gordon R. Greenberg,Anne M. Griffiths,Peter St George-Hyslop,Katherine A. Siminovitch +13 more
TL;DR: It is reported here that two variants in the organic cation transporter cluster at 5q31 (a missense substitution in SLC22A4 and a G→C transversion in the SLC 22A5 promoter) form a haplotype associated with susceptibility to Crohn disease.
Journal ArticleDOI
Pervasive sharing of genetic effects in autoimmune disease.
Chris Cotsapas,Benjamin F. Voight,Benjamin F. Voight,Elizabeth J. Rossin,Kasper Lage,Kasper Lage,Kasper Lage,Benjamin M. Neale,Chris Wallace,Gonçalo R. Abecasis,Jeffrey C. Barrett,Timothy W. Behrens,Judy H. Cho,Philip L. De Jager,Philip L. De Jager,James T. Elder,Robert R. Graham,Peter K. Gregersen,Lars Klareskog,Katherine A. Siminovitch,David A. van Heel,Cisca Wijmenga,Jane Worthington,John A. Todd,David A. Hafler,Stephen S. Rich,Mark J. Daly +26 more
TL;DR: In this article, the authors evaluated the extent of this sharing for 107 immune disease-risk SNPs in seven diseases: celiac disease, Crohn's disease, multiple sclerosis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes.
Journal ArticleDOI
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci.
John D. Rioux,Mark S. Silverberg,Mark J. Daly,A. Hillary Steinhart,Robin S. McLeod,Anne M. Griffiths,Todd Green,Thomas Brettin,Valerie Stone,Shelley B. Bull,Alain Bitton,C. Noel Williams,Gordon R. Greenberg,Zane Cohen,Eric S. Lander,Thomas J. Hudson,Thomas J. Hudson,Katherine A. Siminovitch +17 more
TL;DR: A genomewide scan in 158 Canadian sib-pair families identified three regions of suggestive linkage and one region of significant linkage to 19p13 that contributes to CD susceptibility in families with early-onset disease.