Kimberly Chambert

TL;DR: The results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample, contributing new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.

TL;DR: Copy number variants (CNVs) have been shown to play a role in schizophrenia and intellectual disability and need further investigation to determine their role in disease.

TL;DR: Gene set analyses show that the modest increase in risk from DNMs in SCZ probands is concentrated in genes that are either highly brain expressed, under strong evolutionary constraint, and/or overlap with genes identified as DNM risk factors in other neurodevelopmental disorders.

TL;DR: Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72 and the C9orf72 mutation on chromosome 9p is studied.

TL;DR: CNV burden in BD is limited to SAB, and rare and common genetic variants may contribute differently to risk for psychosis and perhaps other classes of psychiatric symptoms.