L
Laura J. Scott
Researcher at University of Michigan
Publications - 178
Citations - 60906
Laura J. Scott is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 78, co-authored 166 publications receiving 53515 citations. Previous affiliations of Laura J. Scott include National Institutes of Health & SUNY Downstate Medical Center.
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Journal ArticleDOI
A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus.
Tamara S. Roman,Maren E Cannon,Swarooparani Vadlamudi,Martin L. Buchkovich,Brooke N. Wolford,Ryan P. Welch,Mario A. Morken,Grace J. Kwon,Arushi Varshney,Arushi Varshney,Romy Kursawe,Ying Wu,Anne U. Jackson,Michael R. Erdos,Johanna Kuusisto,Markku Laakso,Laura J. Scott,Michael Boehnke,Francis S. Collins,Stephen C. J. Parker,Michael L. Stitzel,Karen L. Mohlke +21 more
TL;DR: It is demonstrated that type 2 diabetes risk alleles are associated with decreased ADCY5 expression in human islets and candidate variants for regulatory function are examined, and data suggest that rs11708067-A risk allele contributes to type 1 diabetes by disrupting an islet enhancer, which results in reduced ADCy5 expression and impaired insulin secretion.
Journal ArticleDOI
A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk
Alisa K. Manning,Alisa K. Manning,Heather M. Highland,Heather M. Highland,Jessica A. Gasser,Xueling Sim,Taru Tukiainen,Taru Tukiainen,Pierre Fontanillas,Niels Grarup,Manuel A. Rivas,Anubha Mahajan,Adam E. Locke,Pablo Cingolani,Tune H. Pers,Ana Viñuela,Ana Viñuela,Andrew A. Brown,Andrew A. Brown,Ying Wu,Jason Flannick,Jason Flannick,Christian Fuchsberger,Eric R. Gamazon,Kyle J. Gaulton,Kyle J. Gaulton,Hae Kyung Im,Tanya M. Teslovich,Thomas W. Blackwell,Jette Bork-Jensen,Noël P. Burtt,Yuhui Chen,Todd Green,Christopher Hartl,Hyun Min Kang,Ashok Kumar,Ashok Kumar,Claes Ladenvall,Clement Ma,Loukas Moutsianas,Richard D. Pearson,John R. B. Perry,John R. B. Perry,John R. B. Perry,N. William Rayner,N. William Rayner,N. William Rayner,Neil R. Robertson,Neil R. Robertson,Laura J. Scott,Martijn van de Bunt,Martijn van de Bunt,Johan G. Eriksson,Antti Jula,Seppo Koskinen,Terho Lehtimäki,Aarno Palotie,Aarno Palotie,Aarno Palotie,Olli T. Raitakari,Olli T. Raitakari,Suzanne B.R. Jacobs,Jennifer Wessel,Audrey Y. Chu,Robert A. Scott,Mark O. Goodarzi,Christine Blancher,Gemma Buck,David Buck,Peter S. Chines,Stacey Gabriel,Anette P. Gjesing,Christopher J. Groves,Mette Hollensted,Jeroen R. Huyghe,Anne U. Jackson,Goo Jun,Johanne Marie Justesen,Massimo Mangino,Jacquelyn Murphy,Matt J. Neville,Robert C. Onofrio,Kerrin S. Small,Heather M. Stringham,Joseph Trakalo,Eric Banks,Jason Carey,Mauricio O. Carneiro,Mark A. DePristo,Yossi Farjoun,Timothy Fennell,Jacqueline I. Goldstein,Jacqueline I. Goldstein,George B. Grant,Martin Hrabé de Angelis,Jared Maguire,Benjamin M. Neale,Benjamin M. Neale,Ryan Poplin,Shaun Purcell,Shaun Purcell,Shaun Purcell,Thomas Schwarzmayr,Khalid Shakir,Joshua D. Smith,Tim M. Strom,Thomas Wieland,Jaana Lindström,Ivan Brandslund,Cramer Christensen,Gabriela L. Surdulescu,Timo A. Lakka,Alex S. F. Doney,Peter M. Nilsson,Nicholas J. Wareham,Claudia Langenberg,Tibor V. Varga,Paul W. Franks,Paul W. Franks,Paul W. Franks,Olov Rolandsson,Anders Rosengren,Vidya S. Farook,Farook Thameem,Sobha Puppala,Satish Kumar,Donna M. Lehman,Christopher P. Jenkinson,Joanne E. Curran,Daniel E. Hale,Sharon P. Fowler,Rector Arya,Ralph A. DeFronzo,Hanna E. Abboud,Ann-Christine Syvänen,Pamela J. Hicks,Nicholette D. Palmer,Maggie C.Y. Ng,Donald W. Bowden,Barry I. Freedman,Tõnu Esko,Reedik Mägi,Lili Milani,Evelin Mihailov,Andres Metspalu,Narisu Narisu,Leena Kinnunen,Lori L. Bonnycastle,Amy J. Swift,Dorota Pasko,Andrew R. Wood,João Fadista,Toni I. Pollin,Nir Barzilai,Gil Atzmon,Benjamin Glaser,Barbara Thorand,Konstantin Strauch,Annette Peters,Michael Roden,Martina Müller-Nurasyid,Liming Liang,Jennifer Kriebel,Thomas Illig,Harald Grallert,Christian Gieger,Christa Meisinger,Lars Lannfelt,Solomon K. Musani,Michael Griswold,Herman A. Taylor,Gregory A Wilson,Adolfo Correa,Heikki Oksa,William R. Scott,Uzma Afzal,Sian-Tsung Tan,Marie Loh,Marie Loh,Marie Loh,John C. Chambers,John C. Chambers,John C. Chambers,Jobanpreet Sehmi,Jaspal S. Kooner,Benjamin Lehne,Yoon Shin Cho,Jong-Young Lee,Bok-Ghee Han,Annemari Käräjämäki,Qibin Qi,Qibin Qi,Lu Qi,Lu Qi,Jinyan Huang,Frank B. Hu,Olle Melander,Marju Orho-Melander,Jennifer E. Below,David Aguilar,Tien Yin Wong,Jianjun Liu,Jianjun Liu,Chiea Chuen Khor,Kee Seng Chia,Wei-Yen Lim,Ching-Yu Cheng,Edmund Chan,E. Shyong Tai,Tin Aung,Allan Linneberg,Allan Linneberg,Bo Isomaa,Thomas Meitinger,Tiinamaija Tuomi,Liisa Hakaste,Jasmina Kravic,Marit E. Jørgensen,Torsten Lauritzen,Panos Deloukas,Kathleen Stirrups,Kathleen Stirrups,Katharine R. Owen,Andrew Farmer,Timothy M. Frayling,Stephen O'Rahilly,Mark Walker,Jonathan C. Levy,Dylan Hodgkiss,Andrew T. Hattersley,Teemu Kuulasmaa,Alena Stančáková,Inês Barroso,Inês Barroso,Dwaipayan Bharadwaj,Juliana C.N. Chan,Giriraj R. Chandak,Mark J. Daly,Peter Donnelly,Peter Donnelly,Shah Ebrahim,Paul Elliott,Tasha E. Fingerlin,Philippe Froguel,Cheng Hu,Weiping Jia,Ronald C.W. Ma,Gilean McVean,Taesung Park,Dorairaj Prabhakaran,Manjinder S. Sandhu,Manjinder S. Sandhu,James Scott,Robert Sladek,Nikhil Tandon,Yik Ying Teo,Eleftheria Zeggini,Richard M. Watanabe,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Y. Antero Kesäniemi,Matti Uusitupa,Tim D. Spector,Veikko Salomaa,Rainer Rauramaa,Colin N. A. Palmer,Inga Prokopenko,Inga Prokopenko,Inga Prokopenko,Andrew D. Morris,Richard N. Bergman,Francis S. Collins,Lars Lind,Erik Ingelsson,Jaakko Tuomilehto,Fredrik Karpe,Leif Groop,Torben Jørgensen,Torben Jørgensen,Torben Hansen,Torben Hansen,Oluf Pedersen,Johanna Kuusisto,Gonçalo R. Abecasis,Graeme I. Bell,John Blangero,Nancy J. Cox,Ravindranath Duggirala,Mark Seielstad,Mark Seielstad,James G. Wilson,Josée Dupuis,Samuli Ripatti,Samuli Ripatti,Craig L. Hanis,Jose C. Florez,Karen L. Mohlke,James B. Meigs,James B. Meigs,Markku Laakso,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Michael Boehnke,David Altshuler,Mark I. McCarthy,Mark I. McCarthy,Anna L. Gloyn,Anna L. Gloyn,Cecilia M. Lindgren,Cecilia M. Lindgren,Cecilia M. Lindgren +312 more
TL;DR: The allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis is extended and bidirectional effects of variants within the pleckstrin homology domain ofAKT2 are demonstrated.
Journal ArticleDOI
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Evangelos Evangelou,Evangelos Evangelou,He Gao,Congying Chu,Georgios Ntritsos,Paul Blakeley,Andrew R. Butts,Raha Pazoki,Hideaki Suzuki,Hideaki Suzuki,Fotios Koskeridis,Andrianos M. Yiorkas,Andrianos M. Yiorkas,Ibrahim Karaman,Joshua Elliott,Qiang Luo,Qiang Luo,Stefanie Aeschbacher,Traci M. Bartz,Sebastian E. Baumeister,Sebastian E. Baumeister,Peter S. Braund,Peter S. Braund,Michael R. Brown,Jennifer A. Brody,Toni-Kim Clarke,Niki Dimou,Jessica D. Faul,Georg Homuth,Anne U. Jackson,Katherine A. Kentistou,Peter K. Joshi,Rozenn N. Lemaitre,Penelope A. Lind,Leo-Pekka Lyytikäinen,Massimo Mangino,Massimo Mangino,Yuri Milaneschi,Christopher P. Nelson,Christopher P. Nelson,Ilja M. Nolte,Mia-Maria Perälä,Ozren Polasek,David J. Porteous,Scott M. Ratliff,Jennifer A. Smith,Alena Stančáková,Alexander Teumer,Samuli Tuominen,Sébastien Thériault,Sébastien Thériault,Jagadish Vangipurapu,John Whitfield,Alexis C. Wood,Jie Yao,Bing Yu,Wei Zhao,Dan E. Arking,Juha Auvinen,Chunyu Liu,Minna Männikkö,Lorenz Risch,Jerome I. Rotter,Harold Snieder,Juha Veijola,Alexandra I. F. Blakemore,Alexandra I. F. Blakemore,Michael Boehnke,Harry Campbell,David Conen,Johan G. Eriksson,Johan G. Eriksson,Hans J. Grabe,Hans J. Grabe,Xiuqing Guo,Pim van der Harst,Catharina A. Hartman,Caroline Hayward,Andrew C. Heath,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Mika Kähönen,Sharon L.R. Kardia,Michael Kühne,Johanna Kuusisto,Markku Laakso,Jari Lahti,Terho Lehtimäki,Andrew M. McIntosh,Karen L. Mohlke,Alanna C. Morrison,Nicholas G. Martin,Albertine J. Oldehinkel,Brenda W.J.H. Penninx,Bruce M. Psaty,Bruce M. Psaty,Olli T. Raitakari,Igor Rudan,Nilesh J. Samani,Nilesh J. Samani,Laura J. Scott,Tim D. Spector,Niek Verweij,David R. Weir,James F. Wilson,Daniel Levy,Ioanna Tzoulaki,Jimmy D. Bell,Paul M. Matthews,Adrian Rothenfluh,Sylvane Desrivières,Gunter Schumann,Gunter Schumann,Paul Elliott +114 more
TL;DR: This article conducted a meta-analysis of genome-wide association studies of alcohol consumption from the UK Biobank, the Alcohol Genome Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake.
Posted ContentDOI
Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans
Jedidiah Carlson,Laura J. Scott,Adam E. Locke,Matthew Flickinger,Shawn Levy,Richard M. Myers,Michael Boehnke,Hyun Min Kang,Jun Li,Sebastian Zöllner +9 more
TL;DR: This work uses ∼36 million singleton variants from 3,560 whole-genome sequences to infer fine-scale patterns of mutation rate heterogeneity and provides the most refined portrait to date of the factors contributing to genome-wide variability of the human germline mutation rate.
Journal ArticleDOI
Familiality and diagnostic patterns of subphenotypes in the National Institutes of Mental Health bipolar sample.
TL;DR: Evidence of familiality is found for subphenotypes of bipolar disorder (BP) in sibships from families affected with bipolar I, schizoaffective disorder, bipolar type (SAB), bipolar II (BPII), or recurrent unipolar depression (RUDD).