L
Laura J. Scott
Researcher at University of Michigan
Publications - 178
Citations - 60906
Laura J. Scott is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 78, co-authored 166 publications receiving 53515 citations. Previous affiliations of Laura J. Scott include National Institutes of Health & SUNY Downstate Medical Center.
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Journal ArticleDOI
Genome-wide association study identifies eight loci associated with blood pressure
Christopher Newton-Cheh,Christopher Newton-Cheh,Toby Johnson,Toby Johnson,Vesela Gateva,Martin D. Tobin,Murielle Bochud,Lachlan J. M. Coin,Samer S. Najjar,Jing Hua Zhao,Simon Heath,Susana Eyheramendy,Konstantinos A. Papadakis,Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Feng Zhang,Martin Farrall,Toshiko Tanaka,Toshiko Tanaka,Chris Wallace,Chris Wallace,John C. Chambers,Kay-Tee Khaw,Peter M. Nilsson,Pim van der Harst,Silvia Polidoro,Diederick E. Grobbee,N. Charlotte Onland-Moret,N. Charlotte Onland-Moret,Michiel L. Bots,Louise V. Wain,Katherine S. Elliott,Alexander Teumer,Jian'an Luan,Gavin Lucas,Johanna Kuusisto,Paul Burton,David Hadley,Wendy L. McArdle,Morris J. Brown,Anna F. Dominiczak,Stephen Newhouse,Nilesh J. Samani,John Webster,Eleftheria Zeggini,Eleftheria Zeggini,Jacques S. Beckmann,Sven Bergmann,Sven Bergmann,Noha Lim,Kijoung Song,Peter Vollenweider,Gérard Waeber,Dawn M. Waterworth,Xin Yuan,Leif Groop,Marju Orho-Melander,Alessandra Allione,Alessandra Di Gregorio,Simonetta Guarrera,Salvatore Panico,Fulvio Ricceri,Valeria Romanazzi,Carlotta Sacerdote,Paolo Vineis,Inês Barroso,Manjinder S. Sandhu,Manjinder S. Sandhu,Robert Luben,Gabriel Crawford,Pekka Jousilahti,Markus Perola,Markus Perola,Michael Boehnke,Lori L. Bonnycastle,Francis S. Collins,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Timo T. Valle,Cristen J. Willer,Richard N. Bergman,Mario A. Morken,Angela Döring,Christian Gieger,Thomas Illig,Thomas Meitinger,Elin Org,Arne Pfeufer,H.-Erich Wichmann,Sekar Kathiresan,Sekar Kathiresan,Jaume Marrugat,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen M. Schwartz,David S. Siscovick,Isaac Subirana,Nelson B. Freimer,Anna-Liisa Hartikainen,Mark I. McCarthy,Paul F. O'Reilly,Leena Peltonen,Leena Peltonen,Anneli Pouta,Anneli Pouta,Paul E. de Jong,Harold Snieder,Wiek H. van Gilst,Robert Clarke,Anuj Goel,Anders Hamsten,David Altshuler,David Altshuler,Marjo Ritta Jarvelin,Marjo Ritta Jarvelin,Marjo Ritta Jarvelin,Paul Elliott,Edward G. Lakatta,Nita G. Forouhi,Nicholas J. Wareham,Ruth J. F. Loos,Panos Deloukas,Sheila Bingham,Diana Zelenika,David P. Strachan,Nicole Soranzo,Nicole Soranzo,Frances M K Williams,Guangju Zhai,Tim D. Spector,John F. Peden,Hugh Watkins,Luigi Ferrucci,Mark J. Caulfield,Patricia B. Munroe,Göran Berglund,Olle Melander,Guiseppe Matullo,Cuno S. P. M. Uiterwaal,Yvonne T. van der Schouw,Mattijs E. Numans,Florian Ernst,Georg Homuth,Uwe Völker,Roberto Eluosa,Markku Laakso,John M. C. Connell,Vincent Mooser,Veikko Salomaa,Jaakko Tuomilehto,Jaakko Tuomilehto,Maris Laan,Gerjan Navis,Udo Seedorf,Ann-Christine Syvänen,Giovanni Tognoni,Serena Sanna,Manuela Uda,Paul Scheet,David Schlessinger,Angelo Scuteri,Marcus Dörr,Stephan B. Felix,Thorsten Reffelmann,Roberto Lorbeer,Henry Völzke,Rainer Rettig,Pilar Galan,Serge Hercberg,Jaspal S. Kooner,Stefania Bandinelli,Pierre Meneton,Gonçalo R. Abecasis,John R. Thompson,Carolina A. Braga Marcano,Beverley Barke,Richard Dobson,Johannie Gungadoo,Kate L. Lee,Abiodun Onipinla,I. Wallace,Mingzhan Xue,David Clayton,H. T. Leung,Sarah Nutland,Neil Walker,John A. Todd,Helen Stevens,David B. Dunger,Barry Widmer,Kate Downes,Kate Downes,Lou R. Cardon,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Jeffrey C. Barrett,David M. Evans,Andrew P. Morris,Cecilia M. Lindgren,Nigel W. Rayner,N J Timpson,N J Timpson,Emily J. Lyons,Fredrik O. Vannberg,Adrian V. S. Hill,Yik Ying Teo,Kirk A. Rockett,Nicholas John Craddock,Antony P. Attwood,Antony P. Attwood,Claire Bryan,Suzannah Bumpstead,Amy Chaney,Jilur Ghori,Rhian G. William,Sarah E. Hunt,Michael Inouye,Emma Keniry,Emma King,Ralph McGinnis,Simon C. Potter,Rathi Ravindrarajan,Pamela Whittaker,David Withers,David Bentley,David Bentley,Christopher J. Groves,Audrey Duncanson,Willem H. Ouwehand,Willem H. Ouwehand,James P. Boorman,James P. Boorman,Barbera Cant,Jennifer Jolley,Alexandra S. Knight,Kerstin Koch,Niall C. Taylor,Nicholas A. Watkins,Nicholas A. Watkins,Thilo Winzer,Peter S. Braund,Richard J. Dixon,Massimo Mangino,Suzanne Stevens,Peter Donnely,Dan Davidson,Jonathan Marchini,I. C.A. Spencer,Niall Cardin,Teresa Ferreira,Joanne Pereira-Gale,Ingeleif B. Hallgrimsdottir,Bryan Howie,Zhan Su,Damjan Vukcevic,Doug Easton,Ursula Everson,Judith M. Hussey,Elizabeth Meech,Christopher Prowse,Graham R. Walters,Richard Jones,Susan M. Ring,Marcus Prembey,Marcus Prembey,Gerome Breen,David St Clair,Sian Ceasar,Katherine Gordon-Smith,Katherine Gordon-Smith,Lisa Jones,Lisa Jones,Elaine K. Green,Detelinea Grozeva,Marian L. Hamshere,Peter Holmans,Ian Jones,George Kirov,Valentina Moskovina,Ivan Nikolov,Michael Conlon O'Donovan,Michael John Owen,David A. Collier,Amanda Elkin,Anne Farmer,Richard Williamson,Peter McGruffin,Allan H. Young,I. Nicol Ferrier,Stephen G. Ball,Anthony J. Balmforth,Jennifer H. Barrett,D. Timothy Bishop,Mark M. Iles,Azhar Maqbool,Nadira Yuldasheva,Alistair S. Hall,Francesca Bredin,Mark Tremelling,Miles Parkes,Hazel E. Drummond,Charlie W. Lees,Elaine R. Nimmo,Jack Satsangi,Sheila A. Fisher,Cathryn M. Lewis,Clive M. Onnie,Nathalie J. Prescott,Christopher G. Mathew,Alastair Forbes,Jeremy D. Sanderson,Christopher Mathew,Jamie Barbour,M. Khalid Mohiuddin,Catherine E. Todhunter,John C. Mansfield,Tariq Ahmad,Fraser Cummings,Derek P. Jewell,Anne Barton,Ian N. Bruce,Hannah Donovan,Steve Eyre,Paul D. Gilbert,Samantha L. Hider,Anne Hinks,Sally John,Catherine Potter,Alan J. Silman,Deborah P M Symmons,Wendy Thomson,Jane Worthington,Timothy M. Frayling,Rachel M. Freathy,Hana Lango,John R. B. Perry,Michael N. Weedon,Andrew T. Hattersley,Beverley M. Shields,Graham A. Hitman,Mark Walker,Melanie J. Newport,Giorgio Sirugo,David J. Conway,Muminatou Jallow,Linda A. Bradbury,Jennifer L. Pointon,Matthew A. Brown,Matthew A. Brown,C Farrar,Paul Wordsworth,Jayne A. Franklyn,Joanne M. Heward,Matthew J. Simmonds,Stephen C.L. Cough,Sheila Seal,Michael R. Stratton,Nazneen Rahman,An Goris,Stephen Sawcer,Alastair Compston +362 more
TL;DR: In this paper, the association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2(P = 1 × 10-23), FGF5 (P=1 × 10 -21), SH2B3(P= 3 × 10−18), MTHFR(MTHFR), c10orf107(P), ZNF652(ZNF652), PLCD3 (P,P = 5 × 10 −9),
Journal ArticleDOI
Genome-wide association study identifies 30 loci associated with bipolar disorder
Eli A. Stahl,Eli A. Stahl,Gerome Breen,Andreas J. Forstner,Andrew McQuillin,Stephan Ripke,Stephan Ripke,Stephan Ripke,Vassily Trubetskoy,Manuel Mattheisen,Yunpeng Wang,Yunpeng Wang,Jonathan R. I. Coleman,Helena Gaspar,Christiaan de Leeuw,Stacy Steinberg,Jennifer M. Whitehead Pavlides,Maciej Trzaskowski,Enda M. Byrne,Tune H. Pers,Tune H. Pers,Peter Holmans,Alexander Richards,Liam Abbott,Esben Agerbo,Esben Agerbo,Huda Akil,Diego Albani,Ney Alliey-Rodriguez,Thomas Damm Als,Thomas Damm Als,Adebayo Anjorin,Verneri Antilla,Swapnil Awasthi,Judith A. Badner,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Jack D. Barchas,Nicholas Bass,Michael Bauer,Richard A. Belliveau,Sarah E. Bergen,Carsten Bøcker Pedersen,Carsten Bøcker Pedersen,Erlend Bøen,Marco P. Boks,James Boocock,Monika Budde,William E. Bunney,Margit Burmeister,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,William Byerley,Miquel Casas,Felecia Cerrato,Pablo Cervantes,Kimberly Chambert,Alexander W. Charney,Danfeng Chen,Claire Churchhouse,Claire Churchhouse,Toni-Kim Clarke,William Coryell,David Craig,Cristiana Cruceanu,Cristiana Cruceanu,David Curtis,David Curtis,Piotr M. Czerski,Anders M. Dale,Simone de Jong,Franziska Degenhardt,Jurgen Del-Favero,J. Raymond DePaulo,Srdjan Djurovic,Srdjan Djurovic,Amanda Dobbyn,Ashley Dumont,Torbjørn Elvsåshagen,Valentina Escott-Price,Chun Chieh Fan,Sascha B. Fischer,Sascha B. Fischer,Matthew Flickinger,Tatiana Foroud,Liz Forty,Josef Frank,Christine Fraser,Nelson B. Freimer,Louise Frisén,Katrin Gade,Katrin Gade,Diane Gage,Julie Garnham,Claudia Giambartolomei,Marianne Giørtz Pedersen,Marianne Giørtz Pedersen,Jaqueline Goldstein,Scott D. Gordon,Katherine Gordon-Smith,Elaine K. Green,Melissa J. Green,Melissa J. Green,Tiffany A. Greenwood,Jakob Grove,Weihua Guan,Jose Guzman-Parra,Marian L. Hamshere,Martin Hautzinger,Urs Heilbronner,Stefan Herms,Stefan Herms,Stefan Herms,Maria Hipolito,Per Hoffmann,Per Hoffmann,Per Hoffmann,Dominic Holland,Laura M. Huckins,Stéphane Jamain,Stéphane Jamain,Jessica S. Johnson,Anders Juréus,Radhika Kandaswamy,Robert Karlsson,James L. Kennedy,Sarah Kittel-Schneider,James A. Knowles,Manolis Kogevinas,Anna C. Koller,Ralph W. Kupka,Catharina Lavebratt,Jacob Lawrence,William Lawson,Markus Leber,Phil Lee,Phil Lee,Shawn Levy,Jun Li,Chunyu Liu,Susanne Lucae,Anna Maaser,Donald J. MacIntyre,Pamela B. Mahon,Pamela B. Mahon,Wolfgang Maier,Lina Martinsson,Steve McCarroll,Steve McCarroll,Peter McGuffin,Melvin G. McInnis,James McKay,Helena Medeiros,Sarah E. Medland,Fan Meng,Fan Meng,Lili Milani,Grant W. Montgomery,Derek W. Morris,Derek W. Morris,Thomas W. Mühleisen,Thomas W. Mühleisen,Niamh Mullins,Hoang T. Nguyen,Caroline M. Nievergelt,Caroline M. Nievergelt,Annelie Nordin Adolfsson,Evaristus A. Nwulia,Claire O'Donovan,Loes M. Olde Loohuis,Anil P.S. Ori,Lilijana Oruc,Urban Ösby,Roy H. Perlis,Amy Perry,Andrea Pfennig,James B. Potash,Shaun Purcell,Shaun Purcell,Eline J. Regeer,Andreas Reif,Céline S. Reinbold,Céline S. Reinbold,John P. Rice,Fabio Rivas,Margarita Rivera,Margarita Rivera,Panos Roussos,Douglas M. Ruderfer,Euijung Ryu,Cristina Sánchez-Mora,Cristina Sánchez-Mora,Alan F. Schatzberg,William A. Scheftner,Nicholas J. Schork,Cynthia Shannon Weickert,Cynthia Shannon Weickert,Tatyana Shehktman,Paul D. Shilling,Engilbert Sigurdsson,Claire Slaney,Olav B. Smeland,Olav B. Smeland,Janet L. Sobell,Christine Søholm Hansen,Christine Søholm Hansen,Anne T. Spijker,David St Clair,Michael Steffens,John Strauss,John Strauss,Fabian Streit,Jana Strohmaier,Szabolcs Szelinger,Robert C. Thompson,Thorgeir E. Thorgeirsson,Jens Treutlein,Helmut Vedder,Weiqing Wang,Stanley J. Watson,Thomas W. Weickert,Thomas W. Weickert,Stephanie H. Witt,Simon Xi,Wei Xu,Wei Xu,Allan H. Young,Peter P. Zandi,Peng Zhang,Sebastian Zöllner,Rolf Adolfsson,Ingrid Agartz,Ingrid Agartz,Martin Alda,Martin Alda,Lena Backlund,Bernhard T. Baune,Bernhard T. Baune,Frank Bellivier,Wade H. Berrettini,Joanna M. Biernacka,Douglas Blackwood,Michael Boehnke,Anders D. Børglum,Anders D. Børglum,Aiden Corvin,Nicholas John Craddock,Mark J. Daly,Mark J. Daly,Udo Dannlowski,Tõnu Esko,Bruno Etain,Mark A. Frye,Janice M. Fullerton,Janice M. Fullerton,Elliot S. Gershon,Michael Gill,Fernando S. Goes,Maria Grigoroiu-Serbanescu,Joanna Hauser,David M. Hougaard,David M. Hougaard,Christina M. Hultman,Ian Jones,Lisa Jones,René S. Kahn,George Kirov,Mikael Landén,Mikael Landén,Marion Leboyer,Marion Leboyer,Cathryn M. Lewis,Qingqin S. Li,Jolanta Lissowska,Nicholas G. Martin,Nicholas G. Martin,Fermín Mayoral,Susan L. McElroy,Andrew M. McIntosh,Francis J. McMahon,Ingrid Melle,Andres Metspalu,Philip B. Mitchell,Gunnar Morken,Ole Mors,Ole Mors,Preben Bo Mortensen,Preben Bo Mortensen,Bertram Müller-Myhsok,Bertram Müller-Myhsok,Richard M. Myers,Benjamin M. Neale,Benjamin M. Neale,Vishwajit L. Nimgaonkar,Merete Nordentoft,Merete Nordentoft,Markus M. Nöthen,Michael Conlon O'Donovan,Ketil J. Oedegaard,Michael John Owen,Sara A. Paciga,Carlos N. Pato,Michele T. Pato,Danielle Posthuma,Josep Antoni Ramos-Quiroga,Marta Ribasés,Marta Ribasés,Marcella Rietschel,Guy A. Rouleau,Guy A. Rouleau,Martin Schalling,Peter R. Schofield,Peter R. Schofield,Thomas G. Schulze,Alessandro Serretti,Jordan W. Smoller,Jordan W. Smoller,Hreinn Stefansson,Kari Stefansson,Kari Stefansson,Eystein Stordal,Patrick F. Sullivan,Patrick F. Sullivan,Gustavo Turecki,Arne E. Vaaler,Eduard Vieta,John B. Vincent,Thomas Werge,Thomas Werge,Thomas Werge,John I. Nurnberger,Naomi R. Wray,Arianna Di Florio,Arianna Di Florio,Howard J. Edenberg,Sven Cichon,Roel A. Ophoff,Laura J. Scott,Ole A. Andreassen,Ole A. Andreassen,John R. Kelsoe,Pamela Sklar,Pamela Sklar +342 more
TL;DR: Genome-wide analysis identifies 30 loci associated with bipolar disorder, allowing for comparisons of shared genes and pathways with other psychiatric disorders, including schizophrenia and depression.
Journal ArticleDOI
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Anubha Mahajan,Min Jin Go,Weihua Zhang,Jennifer E. Below,Kyle J. Gaulton,Teresa Ferreira,Momoko Horikoshi,Andrew D. Johnson,Maggie C.Y. Ng,Inga Prokopenko,Inga Prokopenko,Danish Saleheen,Xu Wang,Eleftheria Zeggini,Gonçalo R. Abecasis,Linda S. Adair,Peter Almgren,Mustafa Atalay,Tin Aung,Tin Aung,Damiano Baldassarre,Beverley Balkau,Beverley Balkau,Yuqian Bao,Anthony H. Barnett,Anthony H. Barnett,Inês Barroso,Inês Barroso,Inês Barroso,Abdul Basit,Latonya F. Been,John Beilby,John Beilby,Graeme I. Bell,Rafn Benediktsson,Richard N. Bergman,Bernhard OBoehm,Bernhard OBoehm,Eric Boerwinkle,Eric Boerwinkle,Lori L. Bonnycastle,Noël P. Burtt,Qiuyin Cai,Harry Campbell,Jason Carey,Stéphane Cauchi,Mark J. Caulfield,Juliana C.N. Chan,Li Ching Chang,Tien-Jyun Chang,Yi-Cheng Chang,Guillaume Charpentier,Chien-Hsiun Chen,Chien-Hsiun Chen,Han Chen,Yuan-Tsong Chen,Kee Seng Chia,Manickam Chidambaram,Peter S. Chines,Nam H. Cho,Young Min Cho,Lee-Ming Chuang,Francis S. Collins,Marilyn C. Cornelis,David Couper,Andrew Crenshaw,Rob M. van Dam,Rob M. van Dam,John Danesh,Debashish Das,Ulf de Faire,George Dedoussis,Panos Deloukas,Antigone S. Dimas,Christian Dina,Christian Dina,Alex S. F. Doney,Peter Donnelly,Mozhgan Dorkhan,Cornelia M. van Duijn,Josée Dupuis,Josée Dupuis,Sarah Edkins,Paul Elliott,Paul Elliott,Valur Emilsson,Raimund Erbel,Johan G. Eriksson,Jorge Escobedo,Tõnu Esko,Tõnu Esko,Elodie Eury,Jose C. Florez,Jose C. Florez,Pierre Fontanillas,Nita G. Forouhi,Tom Forsén,Caroline S. Fox,Caroline S. Fox,Ross M. Fraser,Timothy M. Frayling,Philippe Froguel,Philippe Froguel,Philippe M. Frossard,Yu-Tang Gao,Karl Gertow,Christian Gieger,Bruna Gigante,Harald Grallert,George B. Grant,Leif Groop,Christopher J. Groves,Elin Grundberg,Elin Grundberg,Elin Grundberg,Candace Guiducci,Anders Hamsten,Bok Ghee Han,Hara Kazuo,Neelam Hassanali,Andrew T. Hattersley,Caroline Hayward,Åsa K. Hedman,Christian Herder,Albert Hofman,Oddgeir L. Holmen,Kees Hovingh,Astradur B. Hreidarsson,Cheng Hu,Frank B. Hu,Jennie Hui,Jennie Hui,Steve E. Humphries,Sarah E. Hunt,David J. Hunter,Kristian Hveem,Zafar I. Hydrie,Hiroshi Ikegami,Thomas Illig,Erik Ingelsson,Erik Ingelsson,Muhammed Islam,Bo Isomaa,Anne U. Jackson,Tazeen H. Jafar,Alan James,Alan James,Weiping Jia,Karl-Heinz Jöckel,Anna Jonsson,Jeremy B M Jowett,Takashi Kadowaki,Hyun Min Kang,Stavroula Kanoni,Wen Hong L. Kao,Sekar Kathiresan,Sekar Kathiresan,Norihiro Kato,Prasad Katulanda,Prasad Katulanda,Sirkka Keinänen-Kiukaanniemi,Ann M. Kelly,Ann M. Kelly,Hassan Khan,Kay-Tee Khaw,Chiea Chuen Khor,Chiea Chuen Khor,Chiea Chuen Khor,Hyung Lae Kim,Sangsoo Kim,Young Jin Kim,Leena Kinnunen,Norman Klopp,Augustine Kong,Eeva Korpi-Hyövälti,Sudhir Kowlessur,Peter Kraft,Jasmina Kravic,Malene M. Kristensen,S. Krithika,Ashok Kumar,Jesús Kumate,Johanna Kuusisto,Soo Heon Kwak,Markku Laakso,Vasiliki Lagou,Timo A. Lakka,Claudia Langenberg,Cordelia Langford,Robert W. Lawrence,Karin Leander,Jen Mai Lee,Nanette R. Lee,Man Li,Xinzhong Li,Yun Li,Junbin Liang,Samuel Liju,Wei-Yen Lim,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Eero Lindholm,Ching-Ti Liu,Jianjun Liu,Stéphane Lobbens,Jirong Long,Ruth J. F. Loos,Ruth J. F. Loos,Wei Lu,Jian'an Luan,Valeriya Lyssenko,Ronald C. WMa,Shiro Maeda,Reedik Mägi,Satu Männistö,David R. Matthews,James B. Meigs,James B. Meigs,Olle Melander,Andres Metspalu,Julia Meyer,Ghazala Mirza,Evelin Mihailov,Susanne Moebus,Viswanathan Mohan,Viswanathan Mohan,Karen L. Mohlke,Andrew D. Morris,Thomas WMühleisen,Martina Müller-Nurasyid,Martina Müller-Nurasyid,Bill Musk,Bill Musk,Jiro Nakamura,Eitaro Nakashima,Pau Navarro,Peng Keat Ng,Alexandra C. Nica,Peter M. Nilsson,Inger Njølstad,Markus M. Nöthen,Keizo Ohnaka,Twee Hee Ong,Katharine R. Owen,Colin N. A. Palmer,James S. Pankow,Kyong Soo Park,Melissa Parkin,Sonali Pechlivanis,Nancy L. Pedersen,Leena Peltonen,John R. B. Perry,John R. B. Perry,Annette Peters,Janani Pinidiyapathirage,Carl G. P. Platou,Simon C. Potter,Jackie F. Price,Lu Qi,Venkatesan Radha,Loukianos S. Rallidis,Asif Rasheed,Wolfgang Rathmann,Rainer Rauramaa,Soumya Raychaudhuri,N. William Rayner,Simon D. Rees,Simon D. Rees,Emil Rehnberg,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Neil Robertson,Michael Roden,Elizabeth J. Rossin,Elizabeth J. Rossin,Elizabeth J. Rossin,Igor Rudan,Denis Rybin,Timo Saaristo,Veikko Salomaa,Juha Saltevo,Maria Samuel,Dharambir KSanghera,Jouko Saramies,James Scott,Laura J. Scott,Robert A. Scott,Ayellet V. Segrè,Ayellet V. Segrè,Joban Sehmi,Joban Sehmi,Bengt Sennblad,Nabi Shah,Sonia Shah,A. Samad Shera,Xiao-Ou Shu,Alan R. Shuldiner,Gunnar Sigurosson,Eric J.G. Sijbrands,Angela Silveira,Xueling Sim,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Kerrin S. Small,Wing-Yee So,Alena Stančáková,Kari Stefansson,Kari Stefansson,Gerald Steinbach,Valgerdur Steinthorsdottir,Kathleen Stirrups,Rona J. Strawbridge,Heather M. Stringham,Qi Sun,Chen Suo,Ann-Christine Syvänen,Ryoichi Takayanagi,Fumihiko Takeuchi,Wan Ting Tay,Tanya M. Teslovich,Barbara Thorand,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Emmi Tikkanen,Emmi Tikkanen,Joseph Trakalo,Elena Tremoli,Mieke D. Trip,Fuu Jen Tsai,Tiinamaija Tuomi,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Adan Valladares-Salgado,Sailaja Vedantam,Sailaja Vedantam,Fabrizio Veglia,Benjamin F. Voight,Benjamin F. Voight,Congrong Wang,Nicholas J. Wareham,Roman Wennauer,Ananda R. Wickremasinghe,Tom Wilsgaard,James F. Wilson,S Wiltshire,Wendy Winckler,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Andrew R. Wood,Jer-Yuarn Wu,Jer-Yuarn Wu,Ying Wu,Ken Yamamoto,Toshimasa Yamauchi,Mingyu Yang,Loic Yengo,Mitsuhiro Yokota,Robin Young,Delilah Zabaneh,Fan Zhang,Rong Zhang,Wei Zheng,Paul Zimmet,David Altshuler,David Altshuler,Donald W. Bowden,Donald W. Bowden,Yoon Shin Cho,Nancy J. Cox,Miguel Cruz,Craig L. Hanis,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Jong-Young Lee,Mark Seielstad,Mark Seielstad,Mark Seielstad,Yik Ying Teo,Yik Ying Teo,Michael Boehnke,Esteban J. Parra,John C. Chambers,John C. Chambers,John C. Chambers,E. Shyong Tai,Mark I. McCarthy,Andrew P. Morris,Andrew P. Morris +395 more
TL;DR: In this paper, the authors aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry.
Journal ArticleDOI
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Iris M. Heid,Anne U. Jackson,Joshua C. Randall,Tthomas W. Winkler,Llu Qi,Valgerdur Ssteinthorsdottir,Ggudmar Tthorleifsson,Ccarola Zillikens,Eelizabeth K. Sspeliotes,Eelizabeth K. Sspeliotes,Reedik Mägi,Tsegaselassie Workalemahu,Charles S. White,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Tamara B. Harris,Ssonja I. Berndt,Eerik Ingelsson,Cristen J. Willer,Michael N. Weedon,Jian'an Luan,Ssailaja Vedantam,Ssailaja Vedantam,Tõnu Eesko,Tuomas O. Kilpeläinen,Zoltán Kutalik,Zoltán Kutalik,Sshengxu Li,Keri L. Monda,Anna L. Dixon,Christopher Holmes,Lee M. Kaplan,Liming Liang,J L Min,Miriam F. Moffatt,Cliona Molony,Ggeorge Nicholson,Eeric E. Sschadt,Eeric E. Sschadt,Krina T. Zondervan,Mary F. Feitosa,Teresa Ferreira,Hana Lango Allen,Robert J. Weyant,Eeleanor Wheeler,Andrew R. Wood,Karol Eestrada,Micheal E. Goddard,Micheal E. Goddard,Guillaume Lettre,Massimo Mangino,Dale R. Nyholt,Sshaun Purcell,Sshaun Purcell,Albert Vernon Ssmith,Peter M. Visscher,Jian Yang,Ssteven A. McCcarroll,Ssteven A. McCcarroll,James Nemesh,Benjamin F. Voight,Benjamin F. Voight,Devin Absher,Najaf Amin,Thor Aspelund,Lachlan J. M. Coin,Nicole L. Glazer,Caroline Hayward,Nancy Heard-Ccosta,Jouke-Jan Hottenga,Åsa Johansson,Åsa Johansson,Toby Johnson,Toby Johnson,Toby Johnson,Marika Kaakinen,Karen Kapur,Karen Kapur,Sshamika Ketkar,Joshua W. Knowles,Peter Kraft,Aldi T. Kraja,Claudia Lamina,Micheal F. Leitzmann,Barbara McKknight,Andrew P. Morris,Ken Oong,John R. B. Perry,Marjolein J. Peters,Oozren Polasek,Inga Prokopenko,Nigel W. Rayner,Ssamuli Ripatti,Ssamuli Ripatti,Fernando Rivadeneira,Neil R. Robertson,Serena Sanna,Ulla Sovio,Ida Surakka,Ida Surakka,Alexander Teumer,Sophie H. Van Wingerden,Veronique Vitart,Jing Hua Zhao,Christine Cavalcanti-Proença,Christine Cavalcanti-Proença,Peter S. Chines,Eeva Fisher,Jennifer R. Kulzer,Cécile Lecoeur,Cécile Lecoeur,Narisu Narisu,Camilla H. Sandholt,Laura J. Scott,Kaisa Silander,Kaisa Silander,Klaus Stark,Mari Lliis Tammesoo,Tanya M. Teslovich,Nicholas J. Timpson,Richard M. Watanabe,Ryan P. Welch,Daniel I. Chasman,Mark E. Cooper,John Oolov Jansson,Johannes Kettunen,Johannes Kettunen,Robert Wlawrence,Niina Pellikka,Niina Pellikka,Markus Perola,Markus Perola,Liesbeth Vandenput,Helene Alavere,Peter Almgren,Larry D. Atwood,Amanda J. Bennett,Reiner Biffar,Lori L. Bonnycastle,Stefan R. Bornstein,Thomas A. Buchanan,Harry Campbell,Ian N. M. Day,Mariano Dei,Marcus Dörr,Paul Eelliott,Paul Eelliott,Michael R. Eerdos,Johan G. Eeriksson,Nelson B. Freimer,Mao Fu,Stefan Gaget,Stefan Gaget,Eeco J.C. Geus,Anette P. Gjesing,Harald Grallert,Jürgen Gräßler,Christopher J. Groves,Candace Guiducci,Anna Lliisa Hartikainen,Neelam Hassanali,Aki S. Havulinna,Karl-Heinz Herzig,Karl-Heinz Herzig,Andrew A. Hicks,Jennie Hui,Jennie Hui,Wilmar Igl,Pekka Jousilahti,Antti Jula,Eeero Kajantie,Leena Kinnunen,Ivana Kolcic,Seppo Koskinen,Peter Kovacs,Heyo K. Kroemer,Vjekoslav Krzelj,Johanna Kuusisto,Kirsti Kvaløy,Jaana Laitinen,Oolivier Lantieri,Mark Lathrop,Marja Llokki Lokki,Robert Luben,Barbara Ludwig,Wendy L. McArdle,Anne McCcarthy,Mario A. Morken,Mari Nelis,Mari Nelis,Matt Neville,Guillaume Paré,Alex N. Parker,John F. Peden,Irene Pichler,Kirsi H. Pietiläinen,Carl G. P. Platou,Anneli Pouta,Anneli Pouta,Martin Ridderstråle,Nilesh J. Samani,Nilesh J. Samani,Jouko Saramies,Juha Sinisalo,Jan Smit,Rona J. Strawbridge,Heather M. Stringham,Amy J. Swift,Maris Teder-Llaving,Maris Teder-Llaving,Brian Thomson,Gianluca Usala,Joyce B.J. Van Mmeurs,Gert-Jan B. van Ommen,Vincent Vatin,Vincent Vatin,Claudia B. Volpato,Henri Wallaschofski,Bragi Walters,Eelisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Deniel R. Witte,Lina Zgaga,Paavo Zitting,John Beilby,John Beilby,Alan L. James,Alan L. James,Mika Kähönen,Terho Lehtimäki,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Lyle J. Palmer,Olli T. Raitakari,Paul M. Ridker,Micheal Stumvoll,Anke Tönjes,Jorma Viikari,Beverley Balkau,Yoav Ben-Shlomo,Richard N. Bergman,Heiner Boeing,George Ddavey Smith,Shah Eebrahim,Philippe Froguel,Philippe Froguel,Philippe Froguel,Torben Hansen,Torben Hansen,Christian Hengstenberg,Kristian Hveem,Bo Isomaa,Torben Jørgensen,Fredrik Karpe,Kay Ttee Khaw,Markku Laakso,Debbie A Lawlor,Michel Marre,Michel Marre,Thomas Meitinger,Andres Metspalu,Andres Metspalu,Kristian Midthjell,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Veikko Salomaa,Peter Schwarz,Tiinamaija Tuomi,Jaakko Tuomilehto,Jaakko Tuomilehto,Timo T. Valle,Nicholas J. Wareham,Alice M. Arnold,Jacques S. Beckmann,Sven Bergmann,Sven Bergmann,Eeric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Francis S. Collins,Gudny Eeiriksdottir,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Andrew T. Hattersley,Albert Hofman,Frank B. Hu,Thomas Illig,Carlos Iribarren,Carlos Iribarren,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,W. H. Linda Kao,Jaakko Kaprio,Jaakko Kaprio,Lenore J. Launer,Patricia B. Munroe,Ben A. Oostra,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Peter P. Pramstaller,Bruce M. Psaty,Bruce M. Psaty,Thomas Quertermous,Aila Rissanen,Igor Rudan,Igor Rudan,Alan R. Shuldiner,Alan R. Shuldiner,Nicole Soranzo,Nicole Soranzo,Tim D. Spector,Ann Cchristine Syvanen,Manuela Uda,André G. Uitterlinden,Henry Völzke,Peter Vollenweider,James F. Wilson,Jacqueline C. M. Witteman,Alan F. Wright,Gonçalo R. Abecasis,M Boehnke,Ingrid B. Borecki,Panos Deloukas,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Robert C. Kaplan,Kari E. North,Jeffrey R. O'Cconnell,Leena Peltonen,David Schlessinger,David P. Strachan,Joel N. Hirschhorn,Joel N. Hirschhorn,Themistocles L. Assimes,H. Eerich Wichmann,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Cornelia Van Dduijn,Kari Stefansson,Kari Stefansson,Adrienne Cupples,Ruth J. F. Loos,Inês Barroso,Inês Barroso,Mark I. McCcarthy,Caroline S. Fox,Karen L. Mohlke,Cecilia M. Lindgren +355 more
TL;DR: A meta-analysis of genome-wide association studies for WHR adjusted for body mass index provides evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Journal ArticleDOI
The genetic architecture of type 2 diabetes
Christian Fuchsberger,Christian Fuchsberger,Jason Flannick,Jason Flannick,Tanya M. Teslovich,Anubha Mahajan,Vineeta Agarwala,Vineeta Agarwala,Kyle J. Gaulton,Clement Ma,Pierre Fontanillas,Loukas Moutsianas,Davis J. McCarthy,Manuel A. Rivas,John R. B. Perry,Xueling Sim,Thomas W. Blackwell,Neil Robertson,N. William Rayner,N. William Rayner,Pablo Cingolani,Adam E. Locke,Juan Fernandez Tajes,Heather M. Highland,Josée Dupuis,Josée Dupuis,Peter S. Chines,Cecilia M. Lindgren,Cecilia M. Lindgren,Christopher Hartl,Anne U. Jackson,Han Chen,Han Chen,Jeroen R. Huyghe,Martijn van de Bunt,Richard D. Pearson,Ashok Kumar,Ashok Kumar,Martina Müller-Nurasyid,Niels Grarup,Heather M. Stringham,Eric R. Gamazon,Jae-Hoon Lee,Yi Chen,Robert A. Scott,Jennifer E. Below,Peng Chen,Jinyan Huang,Min Jin Go,Michael L. Stitzel,Dorota Pasko,Stephen C. J. Parker,Tibor V. Varga,Todd Green,Nicola L. Beer,Aaron G. Day-Williams,Teresa Ferreira,Tasha E. Fingerlin,Momoko Horikoshi,Cheng Hu,Iksoo Huh,Mohammad Kamran Ikram,Mohammad Kamran Ikram,Bong-Jo Kim,Yongkang Kim,Young-Jin Kim,Min-Seok Kwon,Juyoung Lee,Selyeong Lee,Keng-Han Lin,Taylor J. Maxwell,Yoshihiko Nagai,Xu Wang,Ryan P. Welch,Joon Yoon,Weihua Zhang,Weihua Zhang,Nir Barzilai,Benjamin F. Voight,Bok-Ghee Han,Christopher P. Jenkinson,Christopher P. Jenkinson,Teemu Kuulasmaa,Johanna Kuusisto,Alisa K. Manning,Maggie C.Y. Ng,Nicholette D. Palmer,Beverley Balkau,Alena Stančáková,Hanna E. Abboud,Heiner Boeing,Vilmantas Giedraitis,Dorairaj Prabhakaran,Omri Gottesman,James Scott,Jason Carey,Phoenix Kwan,George B. Grant,Joshua D. Smith,Benjamin M. Neale,Benjamin M. Neale,Shaun Purcell,Shaun Purcell,Shaun Purcell,Adam S. Butterworth,Joanna M. M. Howson,Heung Man Lee,Yingchang Lu,Soo Heon Kwak,Wei Zhao,John Danesh,John Danesh,Vincent K. L. Lam,Kyong Soo Park,Danish Saleheen,Wing-Yee So,Claudia H. T. Tam,Uzma Afzal,David Aguilar,Rector Arya,Tin Aung,Tin Aung,Edmund Chan,Carmen Navarro,Ching-Yu Cheng,Ching-Yu Cheng,Domenico Palli,Adolfo Correa,Joanne E. Curran,Denis Rybin,Vidya S. Farook,Sharon P. Fowler,Barry I. Freedman,Michael Griswold,Daniel E. Hale,Pamela J. Hicks,Chiea Chuen Khor,Satish Kumar,Benjamin Lehne,Dorothée Thuillier,Wei-Yen Lim,Jianjun Liu,Jianjun Liu,Yvonne T. van der Schouw,Marie Loh,Marie Loh,Marie Loh,Solomon K. Musani,Sobha Puppala,William R. Scott,Loic Yengo,Sian-Tsung Tan,Sian-Tsung Tan,Herman A. Taylor,Farook Thameem,Gregory P. Wilson,Tien Yin Wong,Tien Yin Wong,Pål R. Njølstad,Jonathan C. Levy,Massimo Mangino,Lori L. Bonnycastle,Thomas Schwarzmayr,João Fadista,Gabriela L. Surdulescu,Christian Herder,Christopher J. Groves,Thomas Wieland,Jette Bork-Jensen,Ivan Brandslund,Cramer Christensen,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Alex S. F. Doney,Leena Kinnunen,Tõnu Esko,Tõnu Esko,Tõnu Esko,Andrew Farmer,Liisa Hakaste,Dylan Hodgkiss,Jasmina Kravic,Valeriya Lyssenko,Mette Hollensted,Marit E. Jørgensen,Torben Jørgensen,Torben Jørgensen,Claes Ladenvall,Johanne Marie Justesen,Annemari Käräjämäki,Jennifer Kriebel,Wolfgang Rathmann,Lars Lannfelt,Torsten Lauritzen,Narisu Narisu,Allan Linneberg,Olle Melander,Lili Milani,Matt Neville,Marju Orho-Melander,Lu Qi,Qibin Qi,Qibin Qi,Michael Roden,Olov Rolandsson,Amy J. Swift,Anders Rosengren,Kathleen Stirrups,Andrew R. Wood,Evelin Mihailov,Christine Blancher,Mauricio O. Carneiro,Jared Maguire,Ryan Poplin,Khalid Shakir,Timothy Fennell,Mark A. DePristo,Martin Hrabé de Angelis,Panos Deloukas,Panos Deloukas,Anette P. Gjesing,Goo Jun,Goo Jun,Peter M. Nilsson,Jacquelyn Murphy,Robert C. Onofrio,Barbara Thorand,Torben Hansen,Torben Hansen,Christa Meisinger,Frank B. Hu,Bo Isomaa,Fredrik Karpe,Liming Liang,Annette Peters,Cornelia Huth,Stephen O'Rahilly,Colin N. A. Palmer,Oluf Pedersen,Rainer Rauramaa,Jaakko Tuomilehto,Veikko Salomaa,Richard M. Watanabe,Ann-Christine Syvänen,Richard N. Bergman,Dwaipayan Bharadwaj,Erwin P. Bottinger,Yoon Shin Cho,Giriraj R. Chandak,Juliana C.N. Chan,Kee Seng Chia,Mark J. Daly,Shah Ebrahim,Claudia Langenberg,Paul Elliott,Kathleen A. Jablonski,Donna M. Lehman,Weiping Jia,Ronald C.W. Ma,Toni I. Pollin,Manjinder S. Sandhu,Manjinder S. Sandhu,Nikhil Tandon,Philippe Froguel,Philippe Froguel,Inês Barroso,Inês Barroso,Yik Ying Teo,Eleftheria Zeggini,Ruth J. F. Loos,Kerrin S. Small,Janina S. Ried,Ralph A. DeFronzo,Harald Grallert,Benjamin Glaser,Andres Metspalu,Nicholas J. Wareham,Mark Walker,Eric Banks,Christian Gieger,Erik Ingelsson,Erik Ingelsson,Hae Kyung Im,Thomas Illig,Paul W. Franks,Paul W. Franks,Paul W. Franks,Gemma Buck,Joseph Trakalo,David Buck,Inga Prokopenko,Inga Prokopenko,Reedik Mägi,Lars Lind,Yossi Farjoun,Katharine R. Owen,Anna L. Gloyn,Konstantin Strauch,Tiinamaija Tuomi,Jaspal S. Kooner,Jaspal S. Kooner,Jong-Young Lee,Taesung Park,Peter Donnelly,Andrew D. Morris,Andrew D. Morris,Andrew T. Hattersley,Donald W. Bowden,Francis S. Collins,Gil Atzmon,Gil Atzmon,John C. Chambers,John C. Chambers,Tim D. Spector,Markku Laakso,Tim M. Strom,Graeme I. Bell,John Blangero,Ravindranath Duggirala,E. Shyong Tai,Gilean McVean,Craig L. Hanis,James G. Wilson,Mark Seielstad,Mark Seielstad,Timothy M. Frayling,James B. Meigs,Nancy J. Cox,Robert Sladek,Eric S. Lander,Stacey Gabriel,Noël P. Burtt,Karen L. Mohlke,Thomas Meitinger,Leif Groop,Leif Groop,Gonçalo R. Abecasis,Jose C. Florez,Jose C. Florez,Laura J. Scott,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Hyun Min Kang,Michael Boehnke,David Altshuler,David Altshuler,David Altshuler,Mark I. McCarthy +349 more
TL;DR: In this paper, the authors performed whole-genome sequencing in 2,657 European individuals with and without diabetes, and exome sequencing for 12,940 individuals from five ancestry groups.