N
Nichola Johnson
Researcher at Institute of Cancer Research
Publications - 87
Citations - 11655
Nichola Johnson is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: Breast cancer & Genome-wide association study. The author has an hindex of 44, co-authored 79 publications receiving 10336 citations. Previous affiliations of Nichola Johnson include The Breast Cancer Research Foundation.
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Journal ArticleDOI
Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.
Yan Guo,Shaneda Warren Andersen,Xiao-Ou Shu,Kyriaki Michailidou,Manjeet K. Bolla,Qin Wang,Montserrat Garcia-Closas,Roger L. Milne,Roger L. Milne,Marjanka K. Schmidt,Jenny Chang-Claude,Jenny Chang-Claude,Allison M Dunning,Stig E. Bojesen,Habibul Ahsan,Kristiina Aittomäki,Irene L. Andrulis,Hoda Anton-Culver,Volker Arndt,Matthias W. Beckmann,Alicia Beeghly-Fadiel,Javier Benitez,Natalia Bogdanova,Bernardo Bonanni,Anne Lise Børresen-Dale,Judith S. Brand,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Thomas Brüning,Barbara Burwinkel,Graham Casey,Georgia Chenevix-Trench,Fergus J. Couch,Angela Cox,Simon S. Cross,Kamila Czene,Peter Devilee,Thilo Dörk,Martine Dumont,Peter A. Fasching,Peter A. Fasching,Jonine Figueroa,Dieter Flesch-Janys,Olivia Fletcher,Henrik Flyger,Florentia Fostira,Marilie D. Gammon,Graham G. Giles,Graham G. Giles,Pascal Guénel,Christopher A. Haiman,Ute Hamann,Maartje J. Hooning,John L. Hopper,Anna Jakubowska,Farzana Jasmine,Mark A. Jenkins,Esther M. John,Esther M. John,Nichola Johnson,Michael Jones,Maria Kabisch,Muhammad G. Kibriya,Julia A. Knight,Linetta B. Koppert,Veli-Matti Kosma,Vessela N. Kristensen,Loic Le Marchand,Eunjung Lee,Jingmei Li,Annika Lindblom,Robert Luben,Jan Lubinski,Kathi Malone,Arto Mannermaa,Sara Margolin,Frederik Marmé,Catriona McLean,Hanne Meijers-Heijboer,Alfons Meindl,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,Janet E. Olson,Jose Ignacio Arias Perez,Barbara Perkins,Paolo Peterlongo,Kelly-Anne Phillips,Katri Pylkäs,Anja Rudolph,Regina M. Santella,Elinor J. Sawyer,Rita K. Schmutzler,Caroline Seynaeve,Mitul Shah,Martha J. Shrubsole,Melissa C. Southey,Anthony J. Swerdlow,Amanda E. Toland,Ian Tomlinson,Diana Torres,Thérèse Truong,Giske Ursin,Rob B. van der Luijt,Senno Verhoef,Alice S. Whittemore,Robert Winqvist,Hui Zhao,Shilin Zhao,Per Hall,Jacques Simard,Peter Kraft,Paul D.P. Pharoah,David J. Hunter,Douglas F. Easton,Wei Zheng +117 more
TL;DR: BMI predicted by genome-wide association studies (GWAS)-identified variants is inversely associated with the risk of both pre- and postmenopausal breast cancer, differs from the positive association reported from studies using measured adult BMI.
Journal ArticleDOI
Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C
Nicola H. Dryden,Laura Broome,Frank Dudbridge,Nichola Johnson,Nick Orr,Stefan Schoenfelder,Takashi Nagano,Simon Andrews,Steven W. Wingett,Iwanka Kozarewa,Ioannis Assiotis,Kerry Fenwick,Sarah Maguire,James Campbell,Rachael Natrajan,Maryou B K Lambros,Eleni Perrakis,Alan Ashworth,Peter Fraser,Olivia Fletcher +19 more
TL;DR: Capture Hi-C (CHi-C), which, by incorporating a sequence capture step into aHi-C protocol, allows high-resolution analysis of targeted regions of the genome, and defines two SNPs that were highly correlated with the published risk variant and that mapped within the bait end of an interaction peak.
Journal ArticleDOI
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers
Juliet D. French,Maya Ghoussaini,Stacey L. Edwards,Kerstin B. Meyer,Kyriaki Michailidou,Shahana Ahmed,Sofia Khan,Mel Maranian,Martin O'Reilly,Kristine M. Hillman,Joshua A. Betts,Thomas L. Carroll,Peter Bailey,Ed Dicks,Jonathan Beesley,Jonathan Tyrer,Ana-Teresa Maia,Andrew H. Beck,Nicholas W. Knoblauch,Constance Chen,Peter Kraft,Daniel R. Barnes,Anna González-Neira,M. Rosario Alonso,Daniel Herrero,Daniel C. Tessier,Daniel Vincent,Francois Bacot,Craig Luccarini,Caroline Baynes,Don M. Conroy,Joe Dennis,Manjeet K. Bolla,Qin Wang,John L. Hopper,Melissa C. Southey,Marjanka K. Schmidt,Annegien Broeks,Senno Verhoef,Sten Cornelissen,Kenneth Muir,Artitaya Lophatananon,Sarah Stewart-Brown,Pornthep Siriwanarangsan,Peter A. Fasching,Peter A. Fasching,Christian R. Loehberg,Arif B. Ekici,Matthias W. Beckmann,Julian Peto,Isabel dos Santos Silva,Nichola Johnson,Zoe Aitken,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Frederik Marmé,Andreas Schneeweiss,Christof Sohn,Barbara Burwinkel,Pascal Guénel,Thérèse Truong,Pierre Laurent-Puig,Florence Menegaux,Stig E. Bojesen,Børge G. Nordestgaard,Sune F. Nielsen,Henrik Flyger,Roger L. Milne,M. Pilar Zamora,Jose Ignacio Arias Perez,Javier Benitez,Hoda Anton-Culver,Hermann Brenner,Heiko Müller,Volker Arndt,Christa Stegmaier,Alfons Meindl,Peter Lichtner,Rita K. Schmutzler,Christoph Engel,Hiltrud Brauch,Ute Hamann,Christina Justenhoven,Kirsimari Aaltonen,Päivi Heikkilä,Kristiina Aittomäki,Carl Blomqvist,Keitaro Matsuo,Hidemi Ito,Hiroji Iwata,Aiko Sueta,Natalia Bogdanova,Natalia Antonenkova,Thilo Dörk,Annika Lindblom,Sara Margolin,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Anna H. Wu,Chiu-Chen Tseng,David Van Den Berg,Daniel O. Stram,Diether Lambrechts,Stéphanie Peeters,Ann Smeets,Giuseppe Floris,Jenny Chang-Claude,Anja Rudolph,Stefan Nickels,Dieter Flesch-Janys,Dieter Flesch-Janys,Paolo Radice,Paolo Peterlongo,Bernardo Bonanni,Domenico Sardella,Fergus J. Couch,Xianshu Wang,Vernon S. Pankratz,Adam M. Lee,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Laura Baglietto,Laura Baglietto,Christopher A. Haiman,Brian E. Henderson,Fredrick R. Schumacher,Loic Le Marchand,Jacques Simard,Mark S. Goldberg,Martine Dumont,Soo Hwang Teo,Cheng Har Yip,Char Hong Ng,Eranga N. Vithana,Vessela N. Kristensen,Wei Zheng,Sandra Deming-Halverson,Martha J. Shrubsole,Jirong Long,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Peter Devilee,Caroline M. Seynaeve,Montserrat Garcia-Closas,Jonine D. Figueroa,Stephen J. Chanock,Jolanta Lissowska,Kamila Czene,Daniel Klevebring,Nils Schoof,Maartje J. Hooning,John W.M. Martens,J. Margriet Collée,Madeleine M.A. Tilanus-Linthorst,Per Hall,Jingmei Li,Jianjun Liu,Keith Humphreys,Xiao-Ou Shu,Wei Lu,Yu Tang Gao,Hui Cai,Angela Cox,Sabapathy P. Balasubramanian,William Blot,Lisa B. Signorello,Qiuyin Cai,Paul D.P. Pharoah,Catherine S. Healey,Mitul Shah,Karen A. Pooley,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Mikael Hartman,Hui Miao,J. H. Sng,Xueling Sim,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Suleeporn Sangrajrang,Valerie Gaborieau,James McKay,Amanda E. Toland,Christine B. Ambrosone,Drakoulis Yannoukakos,Andrew K. Godwin,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Shou Tung Chen,Anthony J. Swerdlow,Alan Ashworth,Nick Orr,Minouk J. Schoemaker,Bruce A.J. Ponder,Heli Nevanlinna,Melissa A. Brown,Georgia Chenevix-Trench,Douglas F. Easton,Alison M. Dunning +214 more
TL;DR: Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13, and Chromatin conformation studies demonstrate that these enhancer and silencer elements interact with each other and with their likely target gene, CCND1.
Journal ArticleDOI
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer
Lang Wu,Wei Shi,Jirong Long,Xingyi Guo,Kyriaki Michailidou,Kyriaki Michailidou,Jonathan Beesley,Manjeet K. Bolla,Xiao-Ou Shu,Yingchang Lu,Qiuyin Cai,Fares Al-Ejeh,E Rozali,Qin Wang,Joe Dennis,Bingshan Li,Chenjie Zeng,Helian Feng,Alexander Gusev,Richard Barfield,Irene L. Andrulis,Hoda Anton-Culver,Volker Arndt,Kristan J. Aronson,Paul L. Auer,Paul L. Auer,Myrto Barrdahl,Caroline Baynes,Matthias W. Beckmann,Javier Benitez,Marina Bermisheva,Carl Blomqvist,Carl Blomqvist,Natalia Bogdanova,Stig E. Bojesen,Hiltrud Brauch,Hiltrud Brauch,Hiltrud Brauch,Hermann Brenner,Louise A. Brinton,Per Broberg,Sara Y. Brucker,Barbara Burwinkel,Barbara Burwinkel,Trinidad Caldés,Federico Canzian,Brian D. Carter,J. Esteban Castelao,Jenny Chang-Claude,Jenny Chang-Claude,Xiaoqing Chen,Tongguang Cheng,Hans Christiansen,Christine L. Clarke,Margriet Collée,Sten Cornelissen,Fergus J. Couch,David Cox,David Cox,Angela Cox,Simon S. Cross,Julie M. Cunningham,Kamila Czene,Mary B. Daly,Peter Devilee,Kimberly F. Doheny,Thilo Dörk,Isabel dos-Santos-Silva,Martine Dumont,Miriam Dwek,Diana Eccles,Ursula Eilber,A. Heather Eliassen,Christoph Engel,Mikael Eriksson,Laura Fachal,Peter A. Fasching,Peter A. Fasching,Jonine D. Figueroa,Jonine D. Figueroa,Dieter Flesch-Janys,Olivia Fletcher,Henrik Flyger,Lin Fritschi,Marike Gabrielson,Manuela Gago-Dominguez,Susan M. Gapstur,Montserrat Garcia-Closas,Mia M. Gaudet,Maya Ghoussaini,Graham G. Giles,Graham G. Giles,Mark S. Goldberg,David E. Goldgar,Anna González-Neira,Pascal Guénel,Eric Hahnen,Christopher A. Haiman,Niclas Håkansson,Per Hall,Emily Hallberg,Ute Hamann,Patricia Harrington,Alexander Hein,Belynda Hicks,Peter Hillemanns,Antoinette Hollestelle,Robert N. Hoover,John L. Hopper,Guanmengqian Huang,Keith Humphreys,David J. Hunter,David J. Hunter,Anna Jakubowska,Wolfgang Janni,Esther M. John,Esther M. John,Nichola Johnson,Kristine Jones,Michael Jones,Audrey Y. Jung,Rudolf Kaaks,Michael J. Kerin,Elza Khusnutdinova,Elza Khusnutdinova,Veli-Matti Kosma,Vessela N. Kristensen,Diether Lambrechts,Loic Le Marchand,Jingmei Li,Sara Lindström,Sara Lindström,Jolanta Lissowska,Wing-Yee Lo,Wing-Yee Lo,Sibylle Loibl,Jan Lubinski,Craig Luccarini,Michael P. Lux,Robert J. MacInnis,Robert J. MacInnis,Tom Maishman,Ivana Maleva Kostovska,Ivana Maleva Kostovska,Arto Mannermaa,JoAnn E. Manson,Sara Margolin,Dimitrios Mavroudis,Hanne Meijers-Heijboer,Alfons Meindl,Usha Menon,J.-P. Meyer,Anna Marie Mulligan,Anna Marie Mulligan,Susan L. Neuhausen,Heli Nevanlinna,Patrick Neven,Sune F. Nielsen,Børge G. Nordestgaard,Olufunmilayo I. Olopade,Janet E. Olson,Håkan Olsson,Paolo Peterlongo,Julian Peto,Dijana Plaseska-Karanfilska,Ross L. Prentice,Nadege Presneau,Katri Pylkäs,Brigitte Rack,Paolo Radice,Nazneen Rahman,Gad Rennert,Hedy S. Rennert,Valerie Rhenius,Atocha Romero,Atocha Romero,Jane Romm,Anja Rudolph,Emmanouil Saloustros,Dale P. Sandler,Elinor J. Sawyer,Marjanka K. Schmidt,Rita K. Schmutzler,Andreas Schneeweiss,Rodney J. Scott,Rodney J. Scott,Christopher G. Scott,Sheila Seal,Mitul Shah,Martha J. Shrubsole,Ann Smeets,Melissa C. Southey,John J. Spinelli,Jennifer Stone,Jennifer Stone,Harald Surowy,Harald Surowy,Anthony J. Swerdlow,Rulla M. Tamimi,William J. Tapper,Jack A. Taylor,Mary Beth Terry,Daniel C. Tessier,Abigail Thomas,Kathrin Thöne,Rob A. E. M. Tollenaar,Diana Torres,Diana Torres,Thérèse Truong,Michael Untch,Celine M. Vachon,David Van Den Berg,Daniel Vincent,Quinten Waisfisz,Clarice R. Weinberg,Camilla Wendt,Alice S. Whittemore,Hans Wildiers,Walter C. Willett,Robert Winqvist,Alicja Wolk,Lucy Xia,Xiaohong R. Yang,Argyrios Ziogas,Elad Ziv,Alison M. Dunning,Paul D.P. Pharoah,Jacques Simard,Roger L. Milne,Roger L. Milne,Stacey L. Edwards,Peter Kraft,Douglas F. Easton,Georgia Chenevix-Trench,Wei Zheng +234 more
TL;DR: A transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk finds 48 candidate genes implicated in breast cancer susceptibility, including 14 at novel loci at loci not yet reported for breast cancer.
Journal Article
Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review.
Olivia Fletcher,Lorna Gibson,Nichola Johnson,Daniel R. Altmann,Jeffrey M P Holly,Alan Ashworth,Julian Peto,Isabel dos Santos Silva +7 more
TL;DR: In this article, the authors reviewed all English-language articles on associations among circulating levels of the insulin-like growth factors and their binding proteins (IGFBP), polymorphisms in their genes, and breast cancer risk.