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Showing papers by "Brunel University London published in 2015"


Journal ArticleDOI
TL;DR: In this article, the authors present the presentation, nomenclature, and methodology associated with the application of physisorption for surface area assessment and pore size analysis.
Abstract: Gas adsorption is an important tool for the characterisation of porous solids and fine powders. Major advances in recent years have made it necessary to update the 1985 IUPAC manual on Reporting Physisorption Data for Gas/Solid Systems. The aims of the present document are to clarify and standardise the presentation, nomenclature and methodology associated with the application of physisorption for surface area assessment and pore size analysis and to draw attention to remaining problems in the interpretation of physisorption data.

11,019 citations


Journal ArticleDOI
Georges Aad1, Brad Abbott2, Jalal Abdallah3, Ovsat Abdinov4  +5117 moreInstitutions (314)
TL;DR: A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H→γγ and H→ZZ→4ℓ decay channels.
Abstract: A measurement of the Higgs boson mass is presented based on the combined data samples of the ATLAS and CMS experiments at the CERN LHC in the H→γγ and H→ZZ→4l decay channels. The results are obtained from a simultaneous fit to the reconstructed invariant mass peaks in the two channels and for the two experiments. The measured masses from the individual channels and the two experiments are found to be consistent among themselves. The combined measured mass of the Higgs boson is mH=125.09±0.21 (stat)±0.11 (syst) GeV.

1,567 citations


Journal ArticleDOI
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2134 moreInstitutions (142)
TL;DR: The couplings of the Higgs boson are probed for deviations in magnitude from the standard model predictions in multiple ways, including searches for invisible and undetected decays, and no significant deviations are found.
Abstract: Properties of the Higgs boson with mass near 125 GeV are measured in proton-proton collisions with the CMS experiment at the LHC. Comprehensive sets of production and decay measurements are combined. The decay channels include gamma gamma, ZZ, WW, tau tau, bb, and mu mu pairs. The data samples were collected in 2011 and 2012 and correspond to integrated luminosities of up to 5.1 inverse femtobarns at 7 TeV and up to 19.7 inverse femtobarns at 8 TeV. From the high-resolution gamma gamma and ZZ channels, the mass of the Higgs boson is determined to be 125.02 +0.26 -0.27 (stat) +0.14 -0.15 (syst) GeV. For this mass value, the event yields obtained in the different analyses tagging specific decay channels and production mechanisms are consistent with those expected for the standard model Higgs boson. The combined best-fit signal relative to the standard model expectation is 1.00 +/- 0.09 (stat) +0.08 -0.07 (theo) +/- 0.07 (syst) at the measured mass. The couplings of the Higgs boson are probed for deviations in magnitude from the standard model predictions in multiple ways, including searches for invisible and undetected decays. No significant deviations are found.

677 citations


Journal ArticleDOI
TL;DR: The construct validity of SDO is clarified by strictly assessing a preference for dominance hierarchies in general, removing a possible confound relating to support for hierarchy benefitting the ingroup.
Abstract: A new conceptualization and measurement of social dominance orientation-individual differences in the preference for group based hierarchy and inequality-is introduced. In contrast to previous measures of social dominance orientation that were designed to be unidimensional, the new measure (SDO7) embeds theoretically grounded subdimensions of SDO-SDO-Dominance (SDO-D) and SDO-Egalitarianism (SDO-E). SDO-D constitutes a preference for systems of group-based dominance in which high status groups forcefully oppress lower status groups. SDO-E constitutes a preference for systems of group-based inequality that are maintained by an interrelated network of subtle hierarchy-enhancing ideologies and social policies. Confirmatory factor and criterion validity analyses confirmed that SDO-D and SDO-E are theoretically distinct and dissociate in terms of the intergroup outcomes they best predict. For the first time, distinct personality and individual difference bases of SDO-D and SDO-E are outlined. We clarify the construct validity of SDO by strictly assessing a preference for dominance hierarchies in general, removing a possible confound relating to support for hierarchy benefitting the ingroup. Consistent with this, results show that among members of a disadvantaged ethnic minority group (African Americans), endorsement of SDO7 is inversely related to ingroup identity. We further demonstrate these effects using nationally representative samples of U.S. Blacks and Whites, documenting the generalizability of these findings. Finally, we introduce and validate a brief 4-item measure of each dimension. This article importantly extends our theoretical understanding of one of the most generative constructs in social psychology, and introduces powerful new tools for its measurement.

609 citations


Journal ArticleDOI
TL;DR: This work provides a general overview of the current state of affairs regarding the understanding, measurement and application of MWL in the design of complex systems over the last three decades, and discusses contemporary challenges for applied research.
Abstract: Mental workload (MWL) is one of the most widely used concepts in ergonomics and human factors and represents a topic of increasing importance. Since modern technology in many working environments imposes ever more cognitive demands upon operators while physical demands diminish, understanding how MWL impinges on performance is increasingly critical. Yet, MWL is also one of the most nebulous concepts, with numerous definitions and dimensions associated with it. Moreover, MWL research has had a tendency to focus on complex, often safety-critical systems (e.g. transport, process control). Here we provide a general overview of the current state of affairs regarding the understanding, measurement and application of MWL in the design of complex systems over the last three decades. We conclude by discussing contemporary challenges for applied research, such as the interaction between cognitive workload and physical workload, and the quantification of workload ‘redlines’ which specify when operators are approachi...

578 citations


Journal ArticleDOI
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam2  +2802 moreInstitutions (215)
04 Jun 2015-Nature
TL;DR: In this paper, the branching fractions of the B meson (B-s(0)) and the B-0 meson decaying into two oppositely charged muons (mu(+) and mu(-)) were observed.
Abstract: The standard model of particle physics describes the fundamental particles and their interactions via the strong, electromagnetic and weak forces. It provides precise predictions for measurable quantities that can be tested experimentally. The probabilities, or branching fractions, of the strange B meson (B-s(0)) and the B-0 meson decaying into two oppositely charged muons (mu(+) and mu(-)) are especially interesting because of their sensitivity to theories that extend the standard model. The standard model predicts that the B-s(0)->mu(+)mu(-) and B-0 ->mu(+)mu(-) decays are very rare, with about four of the former occurring for every billion B-s(0) mesons produced, and one of the latter occurring for every ten billion B-0 mesons(1). A difference in the observed branching fractions with respect to the predictions of the standard model would provide a direction in which the standard model should be extended. Before the Large Hadron Collider (LHC) at CERN2 started operating, no evidence for either decay mode had been found. Upper limits on the branching fractions were an order of magnitude above the standard model predictions. The CMS (Compact Muon Solenoid) and LHCb(Large Hadron Collider beauty) collaborations have performed a joint analysis of the data from proton-proton collisions that they collected in 2011 at a centre-of-mass energy of seven teraelectronvolts and in 2012 at eight teraelectronvolts. Here we report the first observation of the B-s(0)->mu(+)mu(-) decay, with a statistical significance exceeding six standard deviations, and the best measurement so far of its branching fraction. Furthermore, we obtained evidence for the B-0 ->mu(+)mu(-) decay with a statistical significance of three standard deviations. Both measurements are statistically compatible with standard model predictions and allow stringent constraints to be placed on theories beyond the standard model. The LHC experiments will resume taking data in 2015, recording proton-proton collisions at a centre-of-mass energy of 13 teraelectronvolts, which will approximately double the production rates of B-s(0) and B-0 mesons and lead to further improvements in the precision of these crucial tests of the standard model.

467 citations


Journal ArticleDOI
TL;DR: A robust protocol which was nonselective and reproducible, and a considerable reduction in analysis time compared with previous methods, is likely to provide an essential tool for further research into the pathways by which microplastics enter the environment.
Abstract: Microplastics (<5 mm) have been documented in environmental samples on a global scale. While these pollutants may enter aquatic environments via wastewater treatment facilities, the abundance of microplastics in these matrices has not been investigated. Although efficient methods for the analysis of microplastics in sediment samples and marine organisms have been published, no methods have been developed for detecting these pollutants within organic-rich wastewater samples. In addition, there is no standardized method for analyzing microplastics isolated from environmental samples. In many cases, part of the identification protocol relies on visual selection before analysis, which is open to bias. In order to address this, a new method for the analysis of microplastics in wastewater was developed. A pretreatment step using 30% hydrogen peroxide (H2O2) was employed to remove biogenic material, and focal plane array (FPA)-based reflectance micro-Fourier-transform (FT-IR) imaging was shown to successfully im...

426 citations


Journal ArticleDOI
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam2  +2119 moreInstitutions (141)
29 May 2015
TL;DR: In this paper, a search for particle dark matter (DM), extra dimensions, and unparticles using events containing a jet and an imbalance in transverse momentum was conducted at the LHC.
Abstract: Results are presented from a search for particle dark matter (DM), extra dimensions, and unparticles using events containing a jet and an imbalance in transverse momentum. The data were collected by the CMS detector in proton-proton collisions at the LHC and correspond to an integrated luminosity of 19.7 fb$^{-1}$ at a centre-of-mass energy of 8 TeV. The number of observed events is found to be consistent with the standard model prediction. Limits are placed on the DM-nucleon scattering cross section as a function of the DM particle mass for spin-dependent and spin-independent interactions. Limits are also placed on the scale parameter $M_\mathrm{D}$ in the ADD model of large extra dimensions, and on the unparticle model parameter $\Lambda_\mathrm{U}$. The constraints on ADD models and unparticles are the most stringent limits in this channel and those on the DM-nucleon scattering cross section are an improvement over previous collider results.

425 citations


Journal ArticleDOI
TL;DR: In this paper, the authors explore the micropolitics of the research process and establish a framework for materialist social inquiry methodology and methods, and discuss the epistemological consequences of adopting a materialist ontology.
Abstract: This paper discusses issues of research design and methods in new materialist social inquiry, an approach that is attracting increasing interest across the social sciences as an alternative to either realist or constructionist ontologies. New materialism de-privileges human agency, focusing instead upon how assemblages of the animate and inanimate together produce the world, with fundamental implications for social inquiry methodology and methods. Key to our exploration is the materialist notion of a ‘research-assemblage’ comprising researcher, data, methods and contexts. We use this understanding first to explore the micropolitics of the research process, and then – along with a review of 30 recent empirical studies – to establish a framework for materialist social inquiry methodology and methods. We discuss the epistemological consequences of adopting a materialist ontology.

402 citations


Journal ArticleDOI
TL;DR: In this article, the spin-parity and tensor structure of the interactions of the recently discovered Higgs boson is performed using the H to ZZ, Z gamma*, gamma* gamma* to 4 l, H to WW to l nu l nu, and H to gamma gamma decay modes.
Abstract: The study of the spin-parity and tensor structure of the interactions of the recently discovered Higgs boson is performed using the H to ZZ, Z gamma*, gamma* gamma* to 4 l, H to WW to l nu l nu, and H to gamma gamma decay modes. The full dataset recorded by the CMS experiment during the LHC Run 1 is used, corresponding to an integrated luminosity of up to 5.1 inverse femtobarns at a center-of-mass energy of 7 TeV and up to 19.7 inverse femtobarns at 8 TeV. A wide range of spin-two models is excluded at a 99% confidence level or higher, or at a 99.87% confidence level for the minimal gravity-like couplings, regardless of whether assumptions are made on the production mechanism. Any mixed-parity spin-one state is excluded in the ZZ and WW modes at a greater than 99.999% confidence level. Under the hypothesis that the resonance is a spin-zero boson, the tensor structure of the interactions of the Higgs boson with two vector bosons ZZ, Z gamma, gamma gamma, and WW is investigated and limits on eleven anomalous contributions are set. Tighter constraints on anomalous HVV interactions are obtained by combining the HZZ and HWW measurements. All observations are consistent with the expectations for the standard model Higgs boson with the quantum numbers J[PC]=0[++].

399 citations


Journal ArticleDOI
TL;DR: In this paper, a high-resolution electron microscopy investigation has confirmed the existence of a Ti-rich monolayer on the surface of the (0.0, 0.1) TiB2 surface, which is most likely to be a (1 − 1 2 ) Al3Ti 2DC.

Journal ArticleDOI
TL;DR: The authors revisited the relationship between financial development and economic growth in a panel of 52 middle-income countries over the 1980-2008 period and showed that there is an inverted U-shaped relationship between finance and growth in the long run.

Journal ArticleDOI
TL;DR: Music could be offered as a way to help patients reduce pain and anxiety during the postoperative period, and timing and delivery can be adapted to individual clinical settings and medical teams.

Journal ArticleDOI
TL;DR: Sustainable Product-Service Systems (S.PSS) carry great potential to deliver social well-being and economic prosperity while operating within the limits of our planet as discussed by the authors. They can however be complex to design, test, implement and bring to the mainstream.

Journal ArticleDOI
TL;DR: The first direct search for lepton-flavour-violating decays of the recently discovered Higgs boson (H) is described in this paper, where the search is performed in the H→μτ_e and H→mτ_h channels, where τeτe and τ_h are tau leptons reconstructed in the electronic and hadronic decay channels, respectively.

Journal ArticleDOI
TL;DR: This study proposes a bi-objective mixed possibilistic, two-stage stochastic programming model to address supplier selection and order allocation problem to build the resilient supply base under operational and disruption risks.
Abstract: This study proposes a bi-objective mixed possibilistic, two-stage stochastic programming model to address supplier selection and order allocation problem to build the resilient supply base under operational and disruption risks. The model accounts for epistemic uncertainty of critical data and applies several proactive strategies such as suppliers’ business continuity plans, fortification of suppliers and contracting with backup suppliers to enhance the resilience level of the selected supply base. A five-step method is designed to solve the problem efficiently. The computational results demonstrate the significant impact of considering disruptive events on the selected supply base.

Journal ArticleDOI
TL;DR: Exposure to endocrine-disrupting chemicals in the EU is likely to contribute substantially to disease and dysfunction across the life course with costs in the hundreds of billions of Euros per year.
Abstract: Context: Rapidly increasing evidence has documented that endocrine-disrupting chemicals (EDCs) contribute substantially to disease and disability. Objective: The objective was to quantify a range of health and economic costs that can be reasonably attributed to EDC exposures in the European Union (EU). Design: A Steering Committee of scientists adapted the Intergovernmental Panel on Climate Change weight-of-evidence characterization for probability of causation based upon levels of available epidemiological and toxicological evidence for one or more chemicals contributing to disease by an endocrine disruptor mechanism. To evaluate the epidemiological evidence, the Steering Committee adapted the World Health Organization Grading of Recommendations Assessment, Development and Evaluation (GRADE) Working Group criteria, whereas the Steering Committee adapted definitions recently promulgated by the Danish Environmental Protection Agency for evaluating laboratory and animal evidence of endocrine disruption. Exp...

Journal ArticleDOI
TL;DR: In this paper, the performance of the Cern LHC detector for photon reconstruction and identification in proton-proton collisions at a centre-of-mass energy of 8 TeV at the CERN LHC is described.
Abstract: A description is provided of the performance of the CMS detector for photon reconstruction and identification in proton-proton collisions at a centre-of-mass energy of 8 TeV at the CERN LHC. Details are given on the reconstruction of photons from energy deposits in the electromagnetic calorimeter (ECAL) and the extraction of photon energy estimates. The reconstruction of electron tracks from photons that convert to electrons in the CMS tracker is also described, as is the optimization of the photon energy reconstruction and its accurate modelling in simulation, in the analysis of the Higgs boson decay into two photons. In the barrel section of the ECAL, an energy resolution of about 1% is achieved for unconverted or late-converting photons from H→γγ decays. Different photon identification methods are discussed and their corresponding selection efficiencies in data are compared with those found in simulated events.

Journal ArticleDOI
TL;DR: For instance, this article found that extraverts more frequently updated about their social activities and everyday life, which was motivated by their use of Facebook to communicate and connect with others, while narcissists' tendency to update about their accomplishments explained the greater number of likes and comments that they reported receiving to their updates.

Journal ArticleDOI
TL;DR: In this article, a search for resonances and quantum black holes is performed using the dijet mass spectra measured in proton-proton collisions at s√=8 TeV with the CMS detector at the LHC.
Abstract: A search for resonances and quantum black holes is performed using the dijet mass spectra measured in proton-proton collisions at s√=8 TeV with the CMS detector at the LHC. The data set corresponds to an integrated luminosity of 19.7 fb^(−1). In a search for narrow resonances that couple to quark-quark, quark-gluon, or gluon-gluon pairs, model-independent upper limits, at 95% confidence level, are obtained on the production cross section of resonances, with masses above 1.2 TeV. When interpreted in the context of specific models the limits exclude string resonances with masses below 5.0 TeV; excited quarks below 3.5 TeV; scalar diquarks below 4.7 TeV; W′ bosons below 1.9 TeV or between 2.0 and 2.2 TeV; Z′ bosons below 1.7 TeV; and Randall-Sundrum gravitons below 1.6 TeV. A separate search is conducted for narrow resonances that decay to final states including b quarks. The first exclusion limit is set for excited b quarks, with a lower mass limit between 1.2 and 1.6 TeV depending on their decay properties. Searches are also carried out for wide resonances, assuming for the first time width-to-mass ratios up to 30%, and for quantum black holes with a range of model parameters. The wide resonance search excludes axigluons and colorons with mass below 3.6 TeV, and color-octet scalars with mass below 2.5 TeV. Lower bounds between 5.0 and 6.3 TeV are set on the masses of quantum black holes.

Journal ArticleDOI
TL;DR: A novel definition of consensus in probability is proposed to better describe the dynamics of the consensus process of the addressed stochastic multi-agent systems with state-dependent noises.

Journal ArticleDOI
TL;DR: It is argued that while the adoption of stiffening strategies is likely to be beneficial in avoiding a loss of balance during simple postural tasks, it will ultimately compromise performance in dynamic and highly demanding functional tasks.

Journal ArticleDOI
TL;DR: The vision of the international, EU-funded project SOLUTIONS is described, where three routes are explored to link the occurrence of chemical mixtures at specific sites to the assessment of adverse biological combination effects, and comprehensive arrays of effect-based tools and trait-based field observations are explored.

Journal ArticleDOI
TL;DR: A new approach to conduct case studies of time lags is developed, built on the process marker model, including developing a matrix with a series of overlapping tracks to allow us to present and measure elements within any overall time lag.
Abstract: Background: The time taken, or ‘time lags’, between biomedical/health research and its translation into health improvements is receiving growing attention. Reducing time lags should increase rates of return to such research. However, ways to measure time lags are under-developed, with little attention on where time lags arise within overall timelines. The process marker model has been proposed as a better way forward than the current focus on an increasingly complex series of translation ‘gaps’. Starting from that model, we aimed to develop better methods to measure and understand time lags and develop ways to identify policy options and produce recommendations for future studies. Methods: Following reviews of the literature on time lags and of relevant policy documents, we developed a new approach to conduct case studies of time lags. We built on the process marker model, including developing a matrix with a series of overlapping tracks to allow us to present and measure elements within any overall time lag. We identified a reduced number of key markers or calibration points and tested our new approach in seven case studies of research leading to interventions in cardiovascular disease and mental health. Finally, we analysed the data to address our study’s key aims. Results: The literature review illustrated the lack of agreement on starting points for measuring time lags. We mapped points from policy documents onto our matrix and thus highlighted key areas of concern, for example around delays before new therapies become widely available. Our seven completed case studies demonstrate we have made considerable progress in developing methods to measure and understand time lags. The matrix of overlapping tracks of activity in the research and implementation processes facilitated analysis of time lags along each track, and at the cross-over points where the next track started. We identified some factors that speed up translation through the actions of companies, researchers, funders, policymakers, and regulators. Recommendations for further work are built on progress made, limitations identified and revised terminology.

Journal ArticleDOI
TL;DR: The distributed filtering problem is investigated for a class of discrete time-varying systems with an event-based communication mechanism, where a novel matrix simplification technique is developed to handle the challenges resulting from the sparseness of the sensor network topology and filter structure preserving issues.
Abstract: In this technical note, the distributed filtering problem is investigated for a class of discrete time-varying systems with an event-based communication mechanism. Each intelligent sensor node transmits the data to its neighbors only when the local innovation violates a predetermined Send-on-Delta (SoD) data transmission condition. The aim of the proposed problem is to construct a distributed filter for each sensor node subject to sporadic communications over wireless networks. In terms of an event indicator variable, the triggering information is utilized so as to reduce the conservatism in the filter analysis. An upper bound for the filtering error covariance is obtained in form of Riccati-like difference equations by utilizing the inductive method. Subsequently, such an upper bound is minimized by appropriately designing the filter parameters iteratively, where a novel matrix simplification technique is developed to handle the challenges resulting from the sparseness of the sensor network topology and filter structure preserving issues. The effectiveness of the proposed strategy is illustrated by a numerical simulation.

Journal ArticleDOI
TL;DR: The second-order azimuthal anisotropy Fourier Fourier harmonics, v2, obtained in p-Pb and PbPb collisions over a wide pseudorapidity range based on correlations among six or more charged particles support the interpretation of a collective origin for the previously observed long-range (large Δη) correlations in both systems.
Abstract: The second-order azimuthal anisotropy Fourier harmonics, v2, are obtained in pPb and PbPb collisions over a wide pseudorapidity (eta) range based on correlations among six or more charged particles. The pPb data, corresponding to an integrated luminosity of 35 inverse nanobarns, were collected during the 2013 LHC pPb run at a nucleon-nucleon center-of-mass energy of 5.02 TeV by the CMS experiment. A sample of semi-peripheral PbPb collision data at sqrt(s[NN])= 2.76 TeV, corresponding to an integrated luminosity of 2.5 inverse microbarns and covering a similar range of particle multiplicities as the pPb data, is also analyzed for comparison. The six- and eight-particle cumulant and the Lee-Yang zeros methods are used to extract the v2 coefficients, extending previous studies of two- and four-particle correlations. For both the pPb and PbPb systems, the v2 values obtained with correlations among more than four particles are consistent with previously published four-particle results. These data support the interpretation of a collective origin for the previously observed long-range (large Delta[eta]) correlations in both systems. The ratios of v2 values corresponding to correlations including different numbers of particles are compared to theoretical predictions that assume a hydrodynamic behavior of a pPb system dominated by fluctuations in the positions of participant nucleons. These results provide new insights into the multi-particle dynamics of collision systems with a very small overlapping region.

Journal ArticleDOI
TL;DR: Following the recent examples of the 2008 Olympics and the 2014 FIFA World Cup, sport governing bodies should consider allowing additional recovery periods between and during events, for hydration and body cooling opportunities, when competitions are held in the heat.
Abstract: Exercising in the heat induces thermoregulatory and other physiological strain that can lead to impairments in endurance exercise capacity. The purpose of this consensus statement is to provide up-to-date recommendations to optimise performance during sporting activities undertaken in hot ambient conditions. The most important intervention one can adopt to reduce physiological strain and optimise performance is to heat acclimatise. Heat acclimatisation should comprise repeated exercise-heat exposures over 1–2 weeks. In addition, athletes should initiate competition and training in a euhydrated state and minimise dehydration during exercise. Following the development of commercial cooling systems (eg, cooling-vest), athletes can implement cooling strategies to facilitate heat loss or increase heat storage capacity before training or competing in the heat. Moreover, event organisers should plan for large shaded areas, along with cooling and rehydration facilities, and schedule events in accordance with minimising the health risks of athletes, especially in mass participation events and during the first hot days of the year. Following the recent examples of the 2008 Olympics and the 2014 FIFA World Cup, sport governing bodies should consider allowing additional (or longer) recovery periods between and during events, for hydration and body cooling opportunities, when competitions are held in the heat.

Journal ArticleDOI
TL;DR: Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer.
Abstract: Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety 'Mode of Action' framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.

Journal ArticleDOI
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2353 moreInstitutions (181)
TL;DR: In this paper, a search for a heavy Higgs boson in the H to WW and H to ZZ decay channels is reported, based upon proton-proton collision data samples corresponding to an integrated luminosity of up to 5.1 inverse femtobarns at sqrt(s)=7 TeV and up to 19.7 inverse femto-bars at square root of 8 TeV, recorded by the CMS experiment at the CERN LHC.
Abstract: A search for a heavy Higgs boson in the H to WW and H to ZZ decay channels is reported. The search is based upon proton-proton collision data samples corresponding to an integrated luminosity of up to 5.1 inverse femtobarns at sqrt(s)=7 TeV and up to 19.7 inverse femtobarns at sqrt(s)=8 TeV, recorded by the CMS experiment at the CERN LHC. Several final states of the H to WW and H to ZZ decays are analyzed. The combined upper limit at the 95% confidence level on the product of the cross section and branching fraction exclude a Higgs boson with standard model-like couplings and decays in the range 145 < m[H] < 1000 GeV. We also interpret the results in the context of an electroweak singlet extension of the standard model.

Journal ArticleDOI
TL;DR: A novel framework is proposed for integrated business continuity and disaster recovery planning for efficient and effective resuming and recovering of critical operations after being disrupted and developed a novel interactive augmented e-constraint method to find the final preferred compromise solution.