Institution
Fu Jen Catholic University
Education•Taipei, Taiwan•
About: Fu Jen Catholic University is a education organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Medicine. The organization has 6842 authors who have published 9512 publications receiving 171005 citations. The organization is also known as: FJU & Fu Jen.
Topics: Population, Medicine, Cancer, Hazard ratio, Apoptosis
Papers published on a yearly basis
Papers
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TL;DR: Sublingual buprenorphine is not helpful in relieving the pain associated with hysteroscopy but is associated with significant adverse reactions, and office hysteroscope with a 3.1-mm flexible hysteroscope is a well-tolerated procedure.
57 citations
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TL;DR: The results suggest that ER stress- and mitochondria-mediated cell death is involved in capsaicin-induced apoptosis in NPC-TW 039 cells.
Abstract: Capsaicin, a pungent compound found in hot chili peppers, has been reported to have antitumor activities in many human cancer cell lines, but the induction of precise apoptosis signaling pathway in human nasopharyngeal carcinoma (NPC) cells is unclear. Here, we investigated the molecular mechanisms of capsaicin-induced apoptosis in human NPC, NPC-TW 039, cells. Effects of capsaicin involved endoplasmic reticulum (ER) stress, caspase-3 activation and mitochondrial depolarization. Capsaicin-induced cytotoxic effects (cell death) through G0/G1 phase arrest and induction of apoptosis of NPC-TW 039 cells in a dose-dependent manner. Capsaicin treatment triggered ER stress by promoting the production of reactive oxygen species (ROS), increasing levels of inositol-requiring 1 enzyme (IRE1), growth arrest and DNA-damage-inducible 153 (GADD153) and glucose-regulated protein 78 (GRP78). Other effects included an increase in cytosolic Ca(2+), loss of the mitochondrial transmembrane potential (ΔΨ(m)), releases of cytochrome c and apoptosis-inducing factor (AIF), and activation of caspase-9 and -3. Furthermore, capsaicin induced increases in the ratio of Bax/Bcl-2 and abundance of apoptosis-related protein levels. These results suggest that ER stress- and mitochondria-mediated cell death is involved in capsaicin-induced apoptosis in NPC-TW 039 cells.
57 citations
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Nagoya University1, University of Tokyo2, Budker Institute of Nuclear Physics3, École Polytechnique Fédérale de Lausanne4, Panjab University, Chandigarh5, University of Maribor6, Fu Jen Catholic University7, National Taiwan University8, Yonsei University9, Sungkyunkwan University10, Virginia Tech11, University of Ljubljana12, Nara Women's University13, Osaka University14, Tohoku Gakuin University15, Kyungpook National University16, Saga University17, Niigata University18, Seoul National University19, Graduate University for Advanced Studies20, University of Giessen21, University of Melbourne22, Austrian Academy of Sciences23, University of Sydney24, Osaka City University25, National Central University26, Tokyo University of Agriculture and Technology27, Toho University28, Kanagawa University29, University of Nova Gorica30, Tokyo Metropolitan University31, National United University32, Korea University33, University of Science and Technology of China34
TL;DR: In this article, the authors studied hadronic τ decay modes involving an η meson using 490 fb-1 of data collected with the Belle detector at the KEKB asymmetric-energy e+ e-collider.
57 citations
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TL;DR: In this paper, customer affective responses were used to examine the mediating processes underlying the relationships between customer perceptions of task performance/food quality and perceived value in restaurant dining experience.
57 citations
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TL;DR: It is suggested that Lactobacillus plantarum TWK10 has the potential to be an ergogenic aid to improve aerobic endurance performance via physiological adaptation effects and change in body composition shifted in the healthy direction for TWK 10 administration groups.
Abstract: Probiotics have been rapidly developed for health promotion, but clinical validation of the effects on exercise physiology has been limited. In a previous study, Lactobacillus plantarum TWK10 (TWK10), isolated from Taiwanese pickled cabbage as a probiotic, was demonstrated to improve exercise performance in an animal model. Thus, in the current study, we attempted to further validate the physiological function and benefits through clinical trials for the purpose of translational research. The study was designed as a double-blind placebo-controlled experiment. A total of 54 healthy participants (27 men and 27 women) aged 20–30 years without professional athletic training were enrolled and randomly allocated to the placebo, low (3 × 1010 colony forming units (CFU)), and high dose (9 × 1010 CFU) TWK10 administration groups (n = 18 per group, with equal sexes). The functional and physiological assessments were conducted by exhaustive treadmill exercise measurements (85% VO2max), and related biochemical indices were measured before and after six weeks of administration. Fatigue-associated indices, including lactic acid, blood ammonia, blood glucose, and creatinine kinase, were continuously monitored during 30 min of exercise and a 90 min rest period using fixed intensity exercise challenges (60% VO2max) to understand the physiological adaptation. The systemic inflammation and body compositions were also acquired and analyzed during the experimental process. The results showed that TWK10 significantly elevated the exercise performance in a dose-dependent manner and improved the fatigue-associated features correlated with better physiological adaptation. The change in body composition shifted in the healthy direction for TWK10 administration groups, especially for the high TWK10 dose group, which showed that body fat significantly decreased and muscle mass significantly increased. Taken together, our results suggest that TWK10 has the potential to be an ergogenic aid to improve aerobic endurance performance via physiological adaptation effects.
57 citations
Authors
Showing all 6861 results
Name | H-index | Papers | Citations |
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P. Chang | 170 | 2154 | 151783 |
Christian Guilleminault | 133 | 897 | 68844 |
Pan-Chyr Yang | 102 | 786 | 46731 |
Po-Ren Hsueh | 92 | 1030 | 38811 |
Shyi-Ming Chen | 90 | 425 | 22172 |
Peter J. Rossky | 74 | 280 | 21183 |
Chong-Jen Yu | 72 | 577 | 22940 |
Shuu Jiun Wang | 71 | 502 | 24800 |
Jaw-Town Lin | 67 | 434 | 15482 |
Lung Chi Chen | 63 | 267 | 13929 |
Ronald E. Taam | 59 | 290 | 12383 |
Jiann T. Lin | 58 | 190 | 10801 |
Yueh-Hsiung Kuo | 57 | 618 | 12204 |
San Lin You | 55 | 178 | 16572 |
Liang-Gee Chen | 54 | 582 | 12073 |