Manchester Metropolitan University

About: Manchester Metropolitan University is a education organization based out in Manchester, Manchester, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 5435 authors who have published 16202 publications receiving 442561 citations. The organization is also known as: Manchester Polytechnic & MMU.

Natural products as anti-glycation agents: possible therapeutic potential for diabetic complications.

Abstract: Diabetes mellitus is characterised by hyperglycaemia, lipidaemia and oxidative stress and predisposes affected individuals to long-term complications afflicting the eyes, skin, kidneys, nerves and blood vessels. Increased protein glycation and the subsequent build-up of tissue advanced glycation endproducts (AGEs) contribute towards the pathogenesis of diabetic complications. Protein glycation is accompanied by generation of free radicals through autoxidation of glucose and glycated proteins and via interaction of AGEs with their cell surface receptors (referred to as RAGE). Glycationderived free radicals can damage proteins, lipids and nucleic acids and contribute towards oxidative stress in diabetes. There is interest in compounds with anti-glycation activity as they may offer therapeutic potential in delaying or preventing the onset of diabetic complications. Although many different compounds are under study, only a few have successfully entered clinical trials but none have yet been approved for clinical use. Whilst the search for new synthetic inhibitors of glycation continues, little attention has been paid to anti-glycation compounds from natural sources. In the last few decades the traditional system of medicine has become a topic of global interest. Various studies have indicated that dietary supplementation with combined anti-glycation and antioxidant nutrients may be a safe and simple complement to traditional therapies targeting diabetic complications. Data for forty two plants/constituents studied for anti-glycation activity is presented in this review and some commonly used medicinal plants that possess anti-glycation activity are discussed in detail including their active ingredients, mechanism of action and therapeutic potential.

Cultural values and entrepreneurship

Abstract: A greater understanding of the relationship between cultural issues and entrepreneurial activity is important because of its implication for national and regional development and growth Yet, many

The electrochemistry of CVD graphene: progress and prospects

Abstract: The unique electronic properties of graphene, a one atom thick carbon layer, were reported by scientists in 2004. Since this time graphene has subsequently been found to display several more unique and fascinating electrical, optical and mechanical properties. One particular area in which graphene has reportedly made an impact is in the field of electrochemistry, such as in providing enhancements in energy storage/generation and electrochemical sensing applications. Since 2005, when graphene was shown to be fabricated by the so-called 'Scotch tape technique' where multiple layers of graphene are peeled from a slab of Highly Ordered Pyrolytic Graphite using adhesive tape and transferred onto an appropriate substrate, other fabrication methodologies of graphene have emerged. In the majority of cases, graphene is produced and supplied in solution, such that graphene has to be immobilised onto the desired surface. A fabrication process where graphene is grown upon a substrate and is ready for implementation is the Chemical Vapour Deposition (CVD) of graphene. In this perspective article we overview recent developments in the fabrication of CVD graphene and explore its utilisation in electrochemistry, considering its fundamental understanding through to applications in sensing and energy related devices.