New York University

About: New York University is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 72380 authors who have published 165545 publications receiving 8334030 citations. The organization is also known as: NYU & University of the City of New York.

Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis

Abstract: Background Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis. Methods We randomly assigned 1583 patients with symptomatic knee osteoarthritis to receive 1500 mg of glucosamine daily, 1200 mg of chondroitin sulfate daily, both glucosamine and chondroitin sulfate, 200 mg of celecoxib daily, or placebo for 24 weeks. Up to 4000 mg of acetaminophen daily was allowed as rescue analgesia. Assignment was stratified according to the severity of knee pain (mild [N=1229] vs. moderate to severe [N=354]). The primary outcome measure was a 20 percent decrease in knee pain from baseline to week 24. Results The mean age of the patients was 59 years, and 64 percent were women. Overall, glucosamine and chondroitin sulfate were not significantly better than placebo in reducing knee pain by 20 perce...

Passionate Politics: Emotions and Social Movements

Abstract: Emotions are back. Once at the center of the study of politics, emotions have receded into the shadows during the past three decades, with no place in the rationalistic, structural, and organizational models that dominate academic political analysis. With this new collection of essays, Jeff Goodwin, James M. Jasper, and Francesca Polletta reverse this trend, reincorporating emotions such as anger, indignation, fear, disgust, joy, and love into research on politics and social protest. The tools of cultural analysis are especially useful for probing the role of emotions in politics, the editors and contributors to "Passionate Politics" argue. Moral outrage, the shame of spoiled collective identities, or the joy of imagining a new and better society, are not automatic responses to events. Rather, they are related to moral institutions, felt obligations and rights, and information about expected effects, all of which are culturally and historically variable. With its look at the history of emotions in social thought, examination of the internal dynamics of protest groups, and exploration of the emotional dynamics that arise from interactions and conflicts among political factions and individuals, "Passionate Politics" will lead the way toward an overdue reconsideration of the role of emotions in social movements and politics generally. Contributors: Rebecca Anne Allahyari Edwin Amenta Collin Barker Mabel Berezin Craig Calhoun Randall Collins Frank Dobbin Jeff Goodwin Deborah B. Gould Julian McAllister Groves James M. Jasper Anne Kane Theodore D. Kemper Sharon Erickson Nepstad Steven Pfaff Francesca Polletta Christian Smith Arlene Stein Nancy Whittier Elisabeth Jean Wood Michael P. Young

The Apache Point Observatory Galactic Evolution Experiment (APOGEE)

Abstract: National Science Foundation [AST-1109178, AST-1616636]; Gemini Observatory; Spanish Ministry of Economy and Competitiveness [AYA-2011-27754]; NASA [NNX12AE17G]; Hungarian Academy of Sciences; Hungarian NKFI of the Hungarian National Research, Development and Innovation Office [K-119517]; Alfred P. Sloan Foundation; National Science Foundation; U.S. Department of Energy Office of Science

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

Abstract: Microglia are primary immune sentinels of the CNS. Following injury, these cells migrate or extend processes toward sites of tissue damage. CNS injury is accompanied by release of nucleotides, serving as signals for microglial activation or chemotaxis. Microglia express several purinoceptors, including a G(i)-coupled subtype that has been implicated in ATP- and ADP-mediated migration in vitro. Here we show that microglia from mice lacking G(i)-coupled P2Y(12) receptors exhibit normal baseline motility but are unable to polarize, migrate or extend processes toward nucleotides in vitro or in vivo. Microglia in P2ry(12)(-/-) mice show significantly diminished directional branch extension toward sites of cortical damage in the living mouse. Moreover, P2Y(12) expression is robust in the 'resting' state, but dramatically reduced after microglial activation. These results imply that P2Y(12) is a primary site at which nucleotides act to induce microglial chemotaxis at early stages of the response to local CNS injury.