New York University

About: New York University is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 72380 authors who have published 165545 publications receiving 8334030 citations. The organization is also known as: NYU & University of the City of New York.

Spatial Diversity in Radars—Models and Detection Performance

Abstract: Inspired by recent advances in multiple-input multiple-output (MIMO) communications, this proposal introduces the statistical MIMO radar concept To the authors' knowledge, this is the first time that the statistical MIMO is being proposed for radar The fundamental difference between statistical MIMO and other radar array systems is that the latter seek to maximize the coherent processing gain, while statistical MIMO radar capitalizes on the diversity of target scattering to improve radar performance Coherent processing is made possible by highly correlated signals at the receiver array, whereas in statistical MIMO radar, the signals received by the array elements are uncorrelated Radar targets generally consist of many small elemental scatterers that are fused by the radar waveform and the processing at the receiver, to result in echoes with fluctuating amplitude and phase It is well known that in conventional radar, slow fluctuations of the target radar cross section (RCS) result in target fades that degrade radar performance By spacing the antenna elements at the transmitter and at the receiver such that the target angular spread is manifested, the MIMO radar can exploit the spatial diversity of target scatterers opening the way to a variety of new techniques that can improve radar performance This paper focuses on the application of the target spatial diversity to improve detection performance The optimal detector in the Neyman–Pearson sense is developed and analyzed for the statistical MIMO radar It is shown that the optimal detector consists of noncoherent processing of the receiver sensors' outputs and that for cases of practical interest, detection performance is superior to that obtained through coherent processing An optimal detector invariant to the signal and noise levels is also developed and analyzed In this case as well, statistical MIMO radar provides great improvements over other types of array radars

High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes.

Abstract: Lipopolysaccharide (LPS) is lethal to animals because it activates cytokine release, causing septic shock and tissue injury. Early proinflammatory cytokines (e.g., tumor necrosis factor [TNF] and interleukin [IL]-1) released within the first few hours of endotoxemia stimulate mediator cascades that persist for days and can lead to death. High mobility group 1 protein (HMG-1), a ubiquitous DNA-binding protein, was recently identified as a “late” mediator of endotoxin lethality. Anti–HMG-1 antibodies neutralized the delayed increase in serum HMG-1, and protected against endotoxin lethality, even when passive immunization was delayed until after the early cytokine response. Here we examined whether HMG-1 might stimulate cytokine synthesis in human peripheral blood mononuclear cell cultures. Addition of purified recombinant HMG-1 to human monocyte cultures significantly stimulated the release of TNF, IL-1α, IL-1β, IL-1RA, IL-6, IL-8, macrophage inflammatory protein (MIP)-1α, and MIP-1β; but not IL-10 or IL-12. HMG-1 concentrations that activated monocytes were within the pathological range previously observed in endotoxemic animals, and in serum obtained from septic patients. HMG-1 failed to stimulate cytokine release in lymphocytes, indicating that cellular stimulation was specific. Cytokine release after HMG-1 stimulation was delayed and biphasic compared with LPS stimulation. Computer-assisted image analysis demonstrated that peak intensity of HMG-1–induced cellular TNF staining was comparable to that observed after maximal stimulation with LPS. Administration of HMG-1 to Balb/c mice significantly increased serum TNF levels in vivo. Together, these results indicate that, like other cytokine mediators of endotoxin lethality (e.g., TNF and IL-1), extracellular HMG-1 is a regulator of monocyte proinflammatory cytokine synthesis.

Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017

Abstract: The Fleischner Society Guidelines for management of solid nodules were published in 2005, and separate guidelines for subsolid nodules were issued in 2013. Since then, new information has become available; therefore, the guidelines have been revised to reflect current thinking on nodule management. The revised guidelines incorporate several substantive changes that reflect current thinking on the management of small nodules. The minimum threshold size for routine follow-up has been increased, and recommended follow-up intervals are now given as a range rather than as a precise time period to give radiologists, clinicians, and patients greater discretion to accommodate individual risk factors and preferences. The guidelines for solid and subsolid nodules have been combined in one simplified table, and specific recommendations have been included for multiple nodules. These guidelines represent the consensus of the Fleischner Society, and as such, they incorporate the opinions of a multidisciplinary international group of thoracic radiologists, pulmonologists, surgeons, pathologists, and other specialists. Changes from the previous guidelines issued by the Fleischner Society are based on new data and accumulated experience. © RSNA, 2017 Online supplemental material is available for this article. An earlier incorrect version of this article appeared online. This article was corrected on March 13, 2017.

Memory, navigation and theta rhythm in the hippocampal-entorhinal system

Abstract: In this review, Gyorgy Buzsaki and Edvard Moser discuss the most recent evidence suggesting that the navigation and memory functions of the hippocampus and entorhinal cortex are supported by the same neuronal algorithms. They propose that the mechanisms fueling the memory and mental travel engines in the hippocampal-entorhinal system evolved from the mechanisms supporting navigation in the physical world.