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Institution

Novartis

Company•Basel, Switzerland•
About: Novartis is a company organization based out in Basel, Switzerland. It is known for research contribution in the topics: Alkyl & Population. The organization has 41930 authors who have published 50566 publications receiving 1978996 citations. The organization is also known as: Novartis International AG.
Topics: Alkyl, Population, Alkoxy group, Receptor, Cancer
Papers published on a yearly basis
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Papers
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Journal Article•DOI•
The genome sequence of the plant pathogen Xylella fastidiosa

[...]

Andrew J. G. Simpson1, Fernando C. Reinach2, Paulo Arruda3, F. A. Abreu2, Marcio Luis Acencio2, R. Alvarenga2, Lucia Maria Carareto Alves4, Jorge E. Araya5, Gilson S. Baia2, C. S. Baptista2, Mario H. Barros2, Eric D. Bonaccorsi2, Silvana Bordin3, Joseph M. Bové6, Marcelo R.S. Briones5, M. R.P. Bueno2, Anamaria A. Camargo1, Luis Eduardo Aranha Camargo2, Dirce Maria Carraro2, Helaine Carrer2, N. B. Colauto4, Carlos Augusto Colombo, Fernando Ferreira Costa3, M. C. R. Costa2, Claudio M. Costa-Neto5, Luiz Lehmann Coutinho2, M. Cristofani, Emmanuel Dias-Neto1, C. Docena2, Hamza El-Dorry2, Agda Paula Facincani4, Ari J. S. Ferreira2, V. C.A. Ferreira7, Jesus Aparecido Ferro4, Jane Silveira Fraga2, Suzelei C. França8, Marília Caixeta Franco2, Marcus Frohme9, Luiz Roberto Furlan4, M. Garnier6, Gustavo H. Goldman2, Maria Helena S. Goldman2, Suely Lopes Gomes2, Arthur Gruber2, Paulo L. Ho10, Joerg Hoheisel, M.L. Junqueira, Edson L. Kemper3, João Paulo Kitajima3, José Eduardo Krieger, Eiko E. Kuramae4, F. Laigret6, Marcio Rodrigues Lambais2, Luciana C. C. Leite10, Eliana Gertrudes de Macedo Lemos4, Manoel Victor Franco Lemos4, Silvio A. Lopes8, Catalina Romero Lopes4, J. A. Machado11, Marco Antonio Machado, Alda Maria Backx Noronha Madeira2, Humberto Maciel França Madeira12, Humberto Maciel França Madeira2, Celso Luis Marino4, Marilis V. Marques2, Elizabeth A. L. Martins10, E. M.F. Martins7, Adriana Yamaguti Matsukuma2, Carlos Frederico Martins Menck2, E. C. Miracca2, Cristina Yumi Miyaki2, Claudia Barros Monteiro-Vitorello2, D. H. Moon2, Maria Aparecida Nagai2, Ana L. T. O. Nascimento10, Luis Eduardo Soares Netto2, A. Nhani4, Francisco G. Nobrega13, Francisco G. Nobrega2, Luiz R. Nunes14, Marcos Antonio de Oliveira3, M. C. de Oliveira2, R. C. de Oliveira14, Darío Abel Palmieri4, A. Paris4, B. R. Peixoto2, Gonçalo A.G. Pereira3, H. A. Pereira4, João Bosco Pesquero5, Ronaldo Bento Quaggio2, Patrícia G. Roberto8, Vanderlei Rodrigues2, Artur J.M. Rosa2, V. E. de Rosa4, R. G. de Sá2, Roberto Vicente Santelli2, H. E. Sawasaki, A.C.R. da Silva2, A M da Silva2, F. R. da Silva3, Wilson A. Silva2, J. F. da Silveira5, M. L.Z. Silvestri2, Walter José Siqueira, A. A. de Souza, A. P. de Souza3, M. F. Terenzi2, Daniela Truffi2, Siu Mui Tsai2, M. H. Tsuhako7, Homero Vallada2, M. A. Van Sluys2, Sergio Verjovski-Almeida2, André Luiz Vettore3, Marco Antônio Zago2, Mayana Zatz2, João Meidanis3, João C. Setubal3 •
Ludwig Institute for Cancer Research1, University of São Paulo2, State University of Campinas3, Sao Paulo State University4, Federal University of São Paulo5, Institut national de la recherche agronomique6, Instituto Biológico7, Universidade de Ribeirão Preto8, German Cancer Research Center9, Instituto Butantan10, Novartis11, Pontifícia Universidade Católica do Paraná12, University of Paraíba Valley13, Universidade de Mogi das Cruzes14
13 Jul 2000-Nature
TL;DR: The complete genome sequence of X. fastidiosa clone 9a5c is reported, providing direct evidence of phage-mediated horizontal gene transfer and indicating that the molecular basis for bacterial pathogenicity is both conserved and independent of host.
Abstract: Instituto Ludwig de Pesquisa sobre o Câncer, Rua Prof. Antonio Prudente, 109-4 andar, 01509-010, Sao Paulo-SP

885 citations

Journal Article•DOI•
Involvement of microRNA in AU-rich element-mediated mRNA instability.

[...]

Qing Jing1, Shuang Huang1, Sabine Guth2, Tyler Zarubin1, Andrea Motoyama1, Jianming Chen1, Franco Di Padova2, Sheng-Cai Lin3, Hermann Gram2, Jiahuai Han1 •
Scripps Research Institute1, Novartis2, Hong Kong University of Science and Technology3
11 Mar 2005-Cell
TL;DR: In this paper, an RNAi-based screen performed in Drosophila S2 cells has revealed that Dicer1, Argonaute1 (Ago1) and Ago2, components involved in microRNA processing and function, are required for the rapid decay of mRNA containing AREs of tumor necrosis factor-alpha.

885 citations

Journal Article•DOI•
Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study

[...]

James C. Yao1, Nicola Fazio, Simron Singh2, Roberto Buzzoni, Carlo Carnaghi, Edward M. Wolin3, Jiri Tomasek4, Markus Raderer, Harald Lahner, Maurizio Voi5, Lida Bubuteishvili Pacaud5, Nicolas Rouyrre5, Carolin Sachs5, Juan W. Valle6, Gianfranco Delle Fave7, Eric Van Cutsem8, Margot E T Tesselaar9, Yasuhiro Shimada, Do Youn Oh10, Jonathan R. Strosberg, Matthew H. Kulke11, Marianne Pavel12 •
University of Texas MD Anderson Cancer Center1, Sunnybrook Health Sciences Centre2, University of Kentucky3, Masaryk University4, Novartis5, University of Manchester6, Sapienza University of Rome7, Katholieke Universiteit Leuven8, Netherlands Cancer Institute9, Seoul National University Hospital10, Harvard University11, Charité12
05 Mar 2016-The Lancet
TL;DR: Everolimus is the first targeted agent to show robust anti-tumour activity with acceptable tolerability across a broad range of neuroendocrine tumours, including those arising from the pancreas, lung, and gastrointestinal tract.

881 citations

Journal Article•DOI•
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease.

[...]

Marc Aurel Busche1, Gerhard Eichhoff1, Gerhard Eichhoff2, Helmuth Adelsberger2, Helmuth Adelsberger1, Dorothee Abramowski3, Karl-Heinz Wiederhold3, Christian Haass2, Christian Haass4, Matthias Staufenbiel3, Arthur Konnerth1, Arthur Konnerth2, Olga Garaschuk1, Olga Garaschuk2 •
Technische Universität München1, Protein Sciences2, Novartis3, Ludwig Maximilian University of Munich4
19 Sep 2008-Science
TL;DR: It is suggested that a redistribution of synaptic drive between silent and hyperactive neurons, rather than an overall decrease in synaptic activity, provides a mechanism for the disturbed cortical function in Alzheimer's disease.
Abstract: The neurodegeneration observed in Alzheimer's disease has been associated with synaptic dismantling and progressive decrease in neuronal activity. We tested this hypothesis in vivo by using two-photon Ca2+ imaging in a mouse model of Alzheimer's disease. Although a decrease in neuronal activity was seen in 29% of layer 2/3 cortical neurons, 21% of neurons displayed an unexpected increase in the frequency of spontaneous Ca2+ transients. These "hyperactive" neurons were found exclusively near the plaques of amyloid beta-depositing mice. The hyperactivity appeared to be due to a relative decrease in synaptic inhibition. Thus, we suggest that a redistribution of synaptic drive between silent and hyperactive neurons, rather than an overall decrease in synaptic activity, provides a mechanism for the disturbed cortical function in Alzheimer's disease.

880 citations

Journal Article•DOI•
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans

[...]

Tommi Vatanen1, Tommi Vatanen2, Aleksandar Kostic3, Aleksandar Kostic2, Eva d'Hennezel4, Heli Siljander5, Eric A. Franzosa3, Eric A. Franzosa2, Moran Yassour2, Raivo Kolde3, Hera Vlamakis2, Timothy D. Arthur2, Anu Maaria Hämäläinen5, Aleksandr Peet6, Vallo Tillmann6, Raivo Uibo7, Sergei Mokurov, Natalya Dorshakova8, Jorma Ilonen9, Jorma Ilonen10, Suvi M. Virtanen11, Suvi M. Virtanen12, Susanne J. Szabo4, Jeffrey A. Porter4, Harri Lähdesmäki1, Curtis Huttenhower2, Curtis Huttenhower3, Dirk Gevers2, Thomas W. Cullen4, Mikael Knip, Ramnik J. Xavier •
Aalto University1, Broad Institute2, Harvard University3, Novartis4, University of Helsinki5, Tartu University Hospital6, University of Tartu7, Petrozavodsk State University8, University of Turku9, University of Eastern Finland10, RMIT University11, National Institutes of Health12
05 May 2016-Cell
TL;DR: It is shown that Bacteroides LPS is structurally distinct from E. coli LPS and inhibits innate immune signaling and endotoxin tolerance, and that early colonization by immunologically silencing microbiota may preclude aspects of immune education.

879 citations

Authors

Showing all 41972 results

NameH-indexPapersCitations
Irving L. Weissman2011141172504
Peter J. Barnes1941530166618
Paul G. Richardson1831533155912
Kenneth C. Anderson1781138126072
Jie Zhang1784857221720
Lei Jiang1702244135205
Marc A. Pfeffer166765133043
Jorge E. Cortes1632784124154
Ian A. Wilson15897198221
Peter G. Schultz15689389716
Bruce D. Walker15577986020
Timothy P. Hughes14583191357
Kurt Wüthrich143739103253
Leonard Guarente14335280169
Christopher D.M. Fletcher13867482484
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202318
202285
20211,321
20201,377
20191,376
20181,456