Stony Brook University

About: Stony Brook University is a education organization based out in Stony Brook, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32534 authors who have published 68218 publications receiving 3035131 citations. The organization is also known as: State University of New York at Stony Brook & SUNY Stony Brook.

Schizophrenia as a chronic active brain process: a study of progressive brain structural change subsequent to the onset of schizophrenia

Abstract: Brain structural deviation is known to be present in chronic patients with schizophrenia when compared with normal age-matched individuals. While the assumption is that these differences are based on a neurodevelopmental disturbance, whether they are static or continue to change throughout the disease process remains unknown. The following report describes a prospective follow-up study of first episode cases of schizophrenic illness. Analyses of MRI evaluations on an approximate annual basis for a minimum of four years are presented on 50 patients and 20 controls. Computer-assisted image analysis measuring the volume of several brain regions, using the program ANALYZE (Mayo Clinic), was performed on all scans. Patients were compared with controls for the rate of change over time in size of structures. No differences were found for the volumes of the caudate nucleus, temporal lobes, or hippocampus; and no changes in the degree of cerebral laterality were detected. However, there was a significant difference in the rate of change in the overall volumes of left and right hemispheres (P < 0.0004 and 0.001, respectively), right cerebellum (P < 0.02) and area of the isthmus of the corpus callosum (P < 0.05). The left cerebral ventricle had significantly greater enlargement over time when measured on coronal slice sequences (P < 0.02), but was not detected by axial views. These findings suggest that a subtle active brain process may be continuing through the first few years of a schizophrenic illness causing greater than the normal adult cortical deterioration. Further studies using other methods of image analysis and over a longer period of time are needed to determine the course and nature of this biologic process.

Ism masses and the star formation law at z = 1 to 6: alma observations of dust continuum in 145 galaxies in the cosmos survey field

Abstract: ALMA Cycle 2 observations of long-wavelength dust emission in 145 star-forming galaxies are used to probe the evolution of the star-forming interstellar medium (ISM). We also develop a physical basis and empirical calibration (with 72 low-z and z ~ 2 galaxies) for using the dust continuum as a quantitative probe of ISM masses. The galaxies with the highest star formation rates (SFRs) at = 2.2 and 4.4 have gas masses up to 100 times that of the Milky Way and gas mass fractions reaching 50%–80%, i.e., gas masses 1-4× their stellar masses. We find a single high-z star formation law: SFR = 35 M^(0.89)_(mol) x (1 + z)^(0.95)_(z=2) x (sSFR)^(0.23)_(MS) M⊙yr^(−1)—an approximately linear dependence on the ISM mass and an increased star formation efficiency per unit gas mass at higher redshift. Galaxies above the main sequence (MS) have larger gas masses but are converting their ISM into stars on a timescale only slightly shorter than those on the MS; thus, these "starbursts" are largely the result of having greatly increased gas masses rather than an increased efficiency of converting gas to stars. At z > 1, the entire population of star-forming galaxies has ~2–5 times shorter gas depletion times than low-z galaxies. These shorter depletion times indicate a different mode of star formation in the early universe—most likely dynamically driven by compressive, high-dispersion gas motions—a natural consequence of the high gas accretion rates.

Fibrin and wound healing.

Abstract: Although hemostasis is the major role of fibrin in wound repair, once the clot is present the wound cells must deal with it. The invasion and clearing of fibrin by these cells involves multiple complex processes that may go array XXX and delay wound repair. A good example, of the latter is leg ulcers. These chronic wounds contain a plethora of proteases that digest fibronectin and growth factors in the fibrin clot resulting in a corrupt provisional matrix that no longer supports reepithelialization or granulation tissue formation. Every good wound care provider knows that these wounds will not heal unless the corrupt matrix is removed by vigorous debridement that stimulates the accumulation of a competent provisional matrix.