Institution
Stony Brook University
Education•Stony Brook, New York, United States•
About: Stony Brook University is a education organization based out in Stony Brook, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32534 authors who have published 68218 publications receiving 3035131 citations. The organization is also known as: State University of New York at Stony Brook & SUNY Stony Brook.
Topics: Population, Poison control, Quantum chromodynamics, Large Hadron Collider, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: Patients with adult myotonic dystrophy type 1 are at high risk for arrhythmias and sudden death, and a severe abnormality on the ECG and a diagnosis of an atrial tachyarrhythmia predict sudden death.
Abstract: Background Sudden death can occur as a consequence of cardiac-conduction abnormalities in the neuromuscular disease myotonic dystrophy type 1. The determinants of the risk of sudden death remain imprecise. Methods We assessed whether the electrocardiogram (ECG) was useful in predicting sudden death in 406 adult patients with genetically confirmed myotonic dystrophy type 1. A patient was characterized as having a severe abnormality if the ECG had at least one of the following features: rhythm other than sinus, PR interval of 240 msec or more, QRS duration of 120 msec or more, or second-degree or third-degree atrioventricular block. Results Patients with severe abnormalities according to the entry ECG were older than patients without severe abnormalities, had more severe skeletal-muscle impairment, and were more likely to have heart failure, left ventricular systolic dysfunction, or atrial tachyarrhythmia. Such patients were more likely to receive a pacemaker or an implantable cardioverter–defibrillator dur...
439 citations
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TL;DR: The data reveal a complex network of interactions regulating Myc destruction, and imply that enhanced protein stability contributes to oncogenic transformation by mutant Myc proteins.
Abstract: The human proto-oncogene c-myc encodes a highly unstable transcription factor that promotes cell proliferation. Although the extreme instability of Myc plays an important role in preventing its accumulation in normal cells, little is known about how Myc is targeted for rapid destruction. Here, we have investigated mechanisms regulating the stability of Myc. We show that Myc is destroyed by ubiquitin-mediated proteolysis, and define two elements in Myc that oppositely regulate its stability: a transcriptional activation domain that promotes Myc destruction, and a region required for association with the POZ domain protein Miz-1 that stabilizes Myc. We also show that Myc is stabilized by cancer-associated and transforming mutations within its transcriptional activation domain. Our data reveal a complex network of interactions regulating Myc destruction, and imply that enhanced protein stability contributes to oncogenic transformation by mutant Myc proteins.
439 citations
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TL;DR: The results of the second phase of the Super-Kamiokande solar neutrino measurement are presented and compared to the first phase in this paper, showing no evidence of systematic tendencies between the first and second phases.
Abstract: The results of the second phase of the Super-Kamiokande solar neutrino measurement are presented and compared to the first phase. The solar neutrino flux spectrum and time variation as well as oscillation results are statistically consistent with the first phase and do not show spectral distortion. The time-dependent flux measurement of the combined first and second phases coincides with the full period of solar cycle 23 and shows no correlation with solar activity. The measured {sup 8}B total flux is (2.38{+-}0.05(stat.){sub -0.15}{sup +0.16}(sys.))x10{sup 6} cm{sup -2} s{sup -1} and the day-night difference is found to be (-6.3{+-}4.2(stat.){+-}3.7(sys.))%. There is no evidence of systematic tendencies between the first and second phases.
439 citations
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TL;DR: The results demonstrate the existence of a positive feedback mechanism for the spatial and temporal regulation of Ras, and suggest that Ras.GTP stabilizes the active site of SOS allosterically, and it is shown that the rate of SOS(cat)-stimulated nucleotide release from Ras is increased significantly.
438 citations
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10 Apr 2011TL;DR: This first detailed measurement analysis of network resource usage and subscriber behavior using a large-scale data set collected inside a nationwide 3G cellular data network delivers important insights into network-wide resource usage.
Abstract: We conduct the first detailed measurement analysis of network resource usage and subscriber behavior using a large-scale data set collected inside a nationwide 3G cellular data network. The data set tracks close to a million subscribers over thousands of base stations. We analyze individual subscriber behaviors and observe a significant variation in network usage among subscribers. We characterize subscriber mobility and temporal activity patterns and identify their relation to traffic volume. We then investigate how efficiently radio resources are used by different subscribers as well as by different applications. We also analyze the network traffic from the point of view of the base stations and find significant temporal and spatial variations in different parts of the network, while the aggregated behavior appears predictable. Broadly, our observations deliver important insights into network-wide resource usage. We describe implications in pricing, protocol design and resource and spectrum management.
438 citations
Authors
Showing all 32829 results
Name | H-index | Papers | Citations |
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Zhong Lin Wang | 245 | 2529 | 259003 |
Dennis W. Dickson | 191 | 1243 | 148488 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
David Baker | 173 | 1226 | 109377 |
J. N. Butler | 172 | 2525 | 175561 |
Roderick T. Bronson | 169 | 679 | 107702 |
Nora D. Volkow | 165 | 958 | 107463 |
Jovan Milosevic | 152 | 1433 | 106802 |
Thomas E. Starzl | 150 | 1625 | 91704 |
Paolo Boffetta | 148 | 1455 | 93876 |
Jacques Banchereau | 143 | 634 | 99261 |
Larry R. Squire | 143 | 472 | 85306 |
John D. E. Gabrieli | 142 | 480 | 68254 |
Alexander Milov | 142 | 1143 | 93374 |
Meenakshi Narain | 142 | 1805 | 147741 |