Stony Brook University

About: Stony Brook University is a education organization based out in Stony Brook, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 32534 authors who have published 68218 publications receiving 3035131 citations. The organization is also known as: State University of New York at Stony Brook & SUNY Stony Brook.

Ancient human genomes suggest three ancestral populations for present-day Europeans

Abstract: We sequenced the genomes of a ∼7,000-year-old farmer from Germany and eight ∼8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had ∼44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.

Magnetic Moment of a Massive Neutrino and Neutrino-Spin Rotation

Abstract: A massive Dirac neutrino has a magnetic moment, which causes its spin to precess in a magnetic field This reduces the effective weak cross sections for relativistic neutrinos An estimate on the basis of phenomenological considerations as well as the standard electroweak theory indicates that massive neutrinos from supernovae and neutron stars may contain significant mixtures of negative- and positive-helicity states

The Neutron Star Mass-Radius Relation and the Equation of State of Dense Matter

Abstract: The equation of state (EOS) of dense matter has been a long-sought goal of nuclear physics. EOSs generate unique mass versus radius (M-R) relations for neutron stars, the ultra-dense remnants of stellar evolution. In this work, we determine the neutron star mass-radius relation and, based on recent observations of both transiently accreting and bursting sources, we show that the radius of a 1.4 solar mass neutron star lies between 10.4 and 12.9 km, independent of assumptions about the composition of the core. We show, for the first time, that these constraints remain valid upon removal from our sample of the most extreme transient sources or of the entire set of bursting sources; our constraints also apply even if deconfined quark matter exists in the neutron star core. Our results significantly constrain the dense matter EOS and are furthermore consistent with constraints from both heavy-ion collisions and theoretical studies of neutron matter. We predict a relatively weak dependence of the symmetry energy on the density and a value for the neutron skin thickness of lead which is less than 0.20 fm, results that are testable in forthcoming experiments.

Carbon monoxide provides protection against hyperoxic lung injury.

Abstract: Findings in recent years strongly suggest that the stress-inducible gene heme oxygenase (HO)-1 plays an important role in protection against oxidative stress. Although the mechanism(s) by which this protection occurs is poorly understood, we hypothesized that the gaseous molecule carbon monoxide (CO), a major by-product of heme catalysis by HO-1, may provide protection against oxidative stress. We demonstrate here that animals exposed to a low concentration of CO exhibit a marked tolerance to lethal concentrations of hyperoxia in vivo. This increased survival was associated with highly significant attenuation of hyperoxia-induced lung injury as assessed by the volume of pleural effusion, protein accumulation in the airways, and histological analysis. The lungs were completely devoid of lung airway and parenchymal inflammation, fibrin deposition, and pulmonary edema in rats exposed to hyperoxia in the presence of a low concentration of CO. Furthermore, exogenous CO completely protected against hyperoxia-induced lung injury in rats in which endogenous HO enzyme activity was inhibited with tin protoporphyrin, a selective inhibitor of HO. Rats exposed to CO also exhibited a marked attenuation of hyperoxia-induced neutrophil infiltration into the airways and total lung apoptotic index. Taken together, our data demonstrate, for the first time, that CO can be therapeutic against oxidative stress such as hyperoxia and highlight possible mechanism(s) by which CO may mediate these protective effects.

Toward the delineation of therapeutic change principles.

Abstract: There is a growing discontent among therapists of varying orientations. Psychoanalytic, behavioral, and humanistically oriented clinicians are starting to raise serious questions about the limits of their respective approaches and are becoming more open to contributions from other paradigms. This article documents this trend within the field, which resembles a Kuhnian-type crisis, noting some of the political, economic, and social forces apt to affect our likelihood of ever reaching a consensus within the field and presenting an approach to the delineation and study of commonalities across various orientations.