Technion – Israel Institute of Technology

About: Technion – Israel Institute of Technology is a education organization based out in Haifa, Israel. It is known for research contribution in the topics: Population & Nonlinear system. The organization has 31714 authors who have published 79377 publications receiving 2603976 citations. The organization is also known as: Technion Israel Institute of Technology & Ṭekhniyon, Makhon ṭekhnologi le-Yiśraʼel.

Brain iron and ferritin in Parkinson's and Alzheimer's diseases.

Abstract: Semiquantitative histological evaluation of brain iron and ferritin in Parkinson's (PD) and Alzheimer's disease (DAT) have been performed in paraffin sections of brain regions which included frontal cortex, hippocampus, basal ganglia and brain stem. The results indicate a significant selective increase of Fe3+ and ferritin in substantia nigra zona compacta but not in zona reticulata of Parkinsonian brains, confirming the biochemical estimation of iron. No such changes were observed in the same regions of DAT brains. The increase of iron is evident in astrocytes, macrophages, reactive microglia and non-pigmented neurons, and in damaged areas devoid of pigmented neurons. In substantia nigra of PD and PD/DAT, strong ferritin reactivity was also associated with proliferated microglia. A faint iron staining was seen occasionally in peripheral halo of Lewy bodies. By contrast, in DAT and PD/DAT, strong ferritin immunoreactivity was observed in and around senile plaques and neurofibrillary tangles. The interrelationship between selective increase of iron and ferritin in PD requires further investigation, because both changes could participate in the induction of oxidative stress and neuronal death, due to their ability to promote formation of oxygen radicals.

Simultaneous determination of production cycle and inspection schedules in a production system

Abstract: Classical Economic Manufacturing Quantity EMQ models have usually ignored the possibility of process deterioration and the existence of defective items in the production lot. Moreover, the use of machine inspection for maintenance and restoration purposes has not been considered. On the other hand, past studies on maintenance models do not consider the length of a production run to be a decision variable. This paper addresses the problem of joint control of production cycles or manufacturing quantities and maintenance by inspection. A simple relationship has been developed to determine the effectiveness of maintenance by inspection. Furthermore, when maintenance by inspection is adopted, it is shown that the optimal inspection intervals are equally-spaced. The problem of simultaneous determination of EMQ and the inspection schedules is solved by using an approximation to the cost function. The resulting EMQ is found to be an adjustment to the classical EMQ. Finally, the relationships between different parameter values and the magnitudes of the cost penalty for using the classical EMQ are examined.

Pressure is not a state function for generic active fluids

Abstract: The pressure that a fluid of self-propelled particles exerts on its container is shown to depend on microscopic interactions between fluid and container, suggesting that there is no equation of state for mechanical pressure in generic active systems.

Secular evolution of compact binaries near massive black holes: gravitational wave sources and other exotica

Abstract: The environment near supermassive black holes (SMBHs) in galactic nuclei contains a large number of stars and compact objects. A fraction of these are likely to be members of binaries. Here we discuss the binary population of stellar black holes and neutron stars near SMBHs and focus on the secular evolution of such binaries, due to the perturbation by the SMBH. Binaries with highly inclined orbits with respect to their orbit around the SMBH are strongly affected by secular Kozai processes, which periodically change their eccentricities and inclinations (Kozai cycles). During periapsis approach, at the highest eccentricities during the Kozai cycles, gravitational wave (GW) emission becomes highly efficient. Some binaries in this environment can inspiral and coalesce at timescales much shorter than a Hubble time and much shorter than similar binaries that do not reside near an SMBH. The close environment of SMBHs could therefore serve as a catalyst for the inspiral and coalescence of binaries and strongly affect their orbital properties. Such compact binaries would be detectable as GW sources by the next generation of GW detectors (e.g., advanced-LIGO). Our analysis shows that ~0.5% of such nuclear merging binaries will enter the LIGO observational window while on orbits that are still very eccentric (e 0.5). The efficient GW analysis for such systems would therefore require the use of eccentric templates. We also find that binaries very close to the SMBH could evolve through a complex dynamical (non-secular) evolution, leading to emission of several GW pulses during only a few years (though these are likely to be rare). Finally, we note that the formation of close stellar binaries, X-ray binaries, and their merger products could be induced by similar secular processes, combined with tidal friction rather than GW emission as in the case of compact object binaries.