University of Adelaide

About: University of Adelaide is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Pregnancy. The organization has 27251 authors who have published 79167 publications receiving 2671128 citations. The organization is also known as: The University of Adelaide & Adelaide University.

PolarMask: Single Shot Instance Segmentation With Polar Representation

Abstract: In this paper, we introduce an anchor-box free and single shot instance segmentation method, which is conceptually simple, fully convolutional and can be used by easily embedding it into most off-the-shelf detection methods. Our method, termed PolarMask, formulates the instance segmentation problem as predicting contour of instance through instance center classification and dense distance regression in a polar coordinate. Moreover, we propose two effective approaches to deal with sampling high-quality center examples and optimization for dense distance regression, respectively, which can significantly improve the performance and simplify the training process. Without any bells and whistles, PolarMask achieves 32.9% in mask mAP with single-model and single-scale training/testing on the challenging COCO dataset. For the first time, we show that the complexity of instance segmentation, in terms of both design and computation complexity, can be the same as bounding box object detection and this much simpler and flexible instance segmentation framework can achieve competitive accuracy. We hope that the proposed PolarMask framework can serve as a fundamental and strong baseline for single shot instance segmentation task.

Acute coronary findings at autopsy in heart failure patients with sudden death: results from the assessment of treatment with lisinopril and survival (ATLAS) trial.

Abstract: Background—Sudden unexpected death frequently occurs in chronic heart failure. The importance of acute coronary events in triggering sudden death (SD) is unclear. Methods and Results—We evaluated at autopsy the prevalence of acute coronary findings (coronary thrombus, ruptured plaque, or myocardial infarction [MI]) and their relation to SD. Autopsy results in 171 patients in the randomized ATLAS trial were reviewed. The prevalence of acute coronary findings was 33%: in 54% of patients with significant coronary artery disease (CAD) who died suddenly, 32% who died of myocardial failure, but in non-CAD patients, they were present in only 5% and 10% respectively. The percentage of patients classified as dying of MI was 28% in the autopsy group versus 4% in the nonautopsied group (P<0.0001). Of the autopsied group with acute MI, 97% (31 of 32 patients) with SD and 40% (6 of 15 patients) with myocardial failure did not have the MI diagnosed during life. When undiagnosed MI was classified as “sudden unexpected” ...

Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

Abstract: Vastly stimulated by the discovery of opioid receptors in the early 1970s, preclinical and clinical research was directed at the study of stereoselective neuronal actions of opioids, especially those played in their crucial analgesic role. However, during the past decade, a new appreciation of the non-neuronal actions of opioids has emerged from preclinical research, with specific appreciation for the nonclassic and nonstereoselective sites of action. Opioid activity at Toll-like receptors, newly recognized innate immune pattern recognition receptors, adds substantially to this unfolding story. It is now apparent from molecular and rodent data that these newly identified signaling events significantly modify the pharmacodynamics of opioids by eliciting proinflammatory reactivity from glia, the immunocompetent cells of the central nervous system. These central immune signaling events, including the release of cytokines and chemokines and the associated disruption of glutamate homeostasis, cause elevated neuronal excitability, which subsequently decreases opioid analgesic efficacy and leads to heightened pain states. This review will examine the current preclinical literature of opioid-induced central immune signaling mediated by classic and nonclassic opioid receptors. A unification of the preclinical pharmacology, neuroscience, and immunology of opioids now provides new insights into common mechanisms of chronic pain, naive tolerance, analgesic tolerance, opioid-induced hyperalgesia, and allodynia. Novel pharmacological targets for future drug development are discussed in the hope that disease-modifying chronic pain treatments arising from the appreciation of opioid-induced central immune signaling may become practical.

Long-term black carbon dynamics in cultivated soil

Abstract: Black carbon (BC) is a quantitatively important C pool in the global C cycle due to its relative recalcitrance compared with other C pools. However, mechanisms of BC oxidation and accompanying molecular changes are largely unknown. In this study, the long-term dynamics in quality and quantity of BC were investigated in cultivated soil using X-ray photoelectron spectroscopy (XPS), Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) techniques. BC particles and changes in BC stocks were obtained from soil collected in fields that were cleared from forest by fire at 8 different times in the past (2, 3, 5, 20, 30, 50, 80 and 100 years before sampling) in western Kenya. BC contents rapidly decreased from 12.7 to 3.8 mg C g−1 soil during the first 30 years following deposition, after which they slowly decreased to a steady state at 3.5 mg C g−1 soil. BC-derived C losses from the top 0.1 m over 100 years were estimated at 6,000 kg C ha−1. The initial rapid changes in BC stocks resulted in a mean residence time of only around 8.3 years, which was likely a function of both decomposition as well as transport processes. The molecular properties of BC changed more rapidly on surfaces than in the interior of BC particles and more rapidly during the first 30 years than during the following 70 years. The Oc/C ratios (Oc is O bound to C) and carbonyl groups (C=O) increased over the first 10 and 30 years by 133 and 192%, respectively, indicating oxidation was an important process controlling BC quality. Al, Si, polysaccharides, and to a lesser extent Fe were found on BC particle surfaces within the first few years after BC deposition to soil. The protection by physical and chemical stabilization was apparently sufficient to not only minimize decomposition below detection between 30 and 100 years after deposition, but also physical export by erosion and vertical transport below 0.1 m.

Neurodevelopmental Outcomes of Preterm Infants Fed High-Dose Docosahexaenoic Acid: A Randomized Controlled Trial

Abstract: Context Uncertainty exists about the benefit of dietary docosahexaenoic acid (DHA) on the neurodevelopment of preterm infants. Objective To determine the effect of meeting the estimated DHA requirement of preterm infants on neurodevelopment at 18 months' corrected age. Design, Setting, and Participants Randomized, double-blind controlled trial enrolling infants born at less than 33 weeks' gestation from April 2001 to October 2005 at 5 Australian tertiary hospitals, with follow-up to 18 months. Intervention High-DHA (approximately 1% total fatty acids) enteral feeds compared with standard DHA (approximately 0.3% total fatty acids) from day 2 to 4 of life until term corrected age. Main Outcome Measures Bayley Mental Development Index (MDI) at 18 months' corrected age. A priori subgroup analyses were conducted based on randomization strata (sex and birth weight Results Of the 657 infants enrolled, 93.5% completed the 18-month follow-up. Bayley MDI scores did not differ between the high- and standard-DHA groups (mean difference, 1.9; 95% confidence interval [CI], −1.0 to 4.7). The MDI among girls fed the high-DHA diet was higher than girls fed standard DHA in unadjusted and adjusted analyses (unadjusted mean difference, 4.7; 95% CI, 0.5-8.8; adjusted mean difference, 4.5; 95% CI, 0.5-8.5). The MDI among boys did not differ between groups. For infants born weighing less than 1250 g, the MDI in the high-DHA group was higher than with standard DHA in the unadjusted comparison (mean difference, 4.7; 95% CI, 0.2-9.2) but did not reach statistical significance following adjustment for gestational age, sex, maternal education, and birth order (mean difference, 3.8; 95% CI, −0.5 to 8.0). The MDI among infants born weighing at least 1250 g did not differ between groups. Conclusion A DHA dose of approximately 1% total fatty acids in early life did not increase MDI scores of preterm infants overall born earlier than 33 weeks but did improve the MDI scores of girls. Trial Registration anzctr.org.au Identifier: ACTRN12606000327583