University of Malaya

About: University of Malaya is a education organization based out in Kuala Lumpur, Malaysia. It is known for research contribution in the topics: Population & Fiber laser. The organization has 25087 authors who have published 51491 publications receiving 1036791 citations. The organization is also known as: UM & Universiti Malaya.

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment.

Abstract: Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and characterized by the progressive degeneration of the function and structure of the central nervous system (CNS) for reasons that are not yet understood. Neurodegeneration is the umbrella term for the progressive death of nerve cells and loss of brain tissue. Because of their high energy requirements, neurons are especially vulnerable to injury and death from dysfunctional mitochondria. Widespread damage to mitochondria causes cells to die because they can no longer produce enough energy. Several lines of pathological and physiological evidence reveal that impaired mitochondrial function and dynamics play crucial roles in aging and pathogenesis of neurodegenerative diseases. As mitochondria are the major intracellular organelles that regulate both cell survival and death, they are highly considered as a potential target for pharmacological-based therapies. The purpose of this review was to present the current status of our knowledge and understanding of the involvement of mitochondrial dysfunction in pathogenesis of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS) and the importance of mitochondrial biogenesis as a potential novel therapeutic target for their treatment. Likewise, we highlight a concise overview of the key roles of mitochondrial electron transport chain (ETC.) complexes as well as mitochondrial biogenesis regulators regarding those diseases.

Quantum dot-sensitized solar cells—perspective and recent developments: A review of Cd chalcogenide quantum dots as sensitizers

Abstract: The emergence of quantum dot-sensitized solar cells (QDSSCs) has provided an alternative way to harvest sunlight for energy conversion. Among all the QDSSCs, cadmium chalcogenide (CdX, X=S, Se or Te) based QDSSCs have gained a significant interest due to their easy fabrication, low cost and high performance. However, their performance still does not match with that of their dye-sensitized solar cells (DSSCs) counterpart. In this review, the concept and mechanism behind the QDSSCs are reviewed. Fabrication methods and possible approaches for improving the Cd chalcogenide QDSSC performance are also discussed. It is worthwhile to note that the efficiency of a QDSSC depends on the fabrication method of the quantum dots, morphology of the photoanode, type of electrolyte used and the choice of the counter electrode. It is therefore, imperative for engineering of materials and optimization of the fabrication method for the improvement of QDSSCs performance.

Impacts of biodiesel combustion on NOx emissions and their reduction approaches

Abstract: Increasing energy demand and environment concerns have prompted an evolution of alternative fuel sources. As an alternative fuel source, biodiesel is attractive because it reduces engine emissions. However, biodiesel produces higher NOx emissions compared to ordinary diesel fuel. Previous researches have established many factors that cause biodiesel to produce elevated NOx emissions. This study reviews the impacts of biodiesel combustion on NOx emissions and their reduction approaches in diesel engines. The first part of this study recaps the NOx formation mechanisms for understanding the kinetics behind the NOx forming reactions. The second part describes the factors affecting on NOx emissions. This paper established that higher NOx emissions are produced for biodiesel combustion which influenced by several factors such as physicochemical properties and molecular structure of biodiesel, adiabatic flame temperature, ignition delay time, injection timing and engine load conditions etc. The final section discusses on the reduction of NOx emissions from biodiesel fuelled engines for both pre and post combustion techniques. The results of reduction approaches of the NOx emissions implies, exhaust gas recirculation (EGR) and retarded injection timing are effective as well as low cost techniques than others. Between these two techniques, EGR reduces the NOx emissions at 5–25% EGR rate adequately in biofuelled engine by controlling oxygen content and combustion peak temperature with slightly decreasing HC and CO emissions. However this technique shows few penalties on smoke and PM emissions as well as brake specific fuel consumption if not perfectly optimized.