Institution
University of Massachusetts Boston
Education•Boston, Massachusetts, United States•
About: University of Massachusetts Boston is a education organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Population & Health care. The organization has 6541 authors who have published 12918 publications receiving 411731 citations. The organization is also known as: UMass Boston.
Papers published on a yearly basis
Papers
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TL;DR: In this article, it was shown that for the resonant metal-dielectric structures with sub-wavelength confinement of light in all three dimensions, the loss cannot be reduced considerably below the loss of the metal itself unless one operates in the far IR and THz regions of the spectrum or below.
Abstract: We show that, for the resonant metal-dielectric structures with sub-wavelength confinement of light in all three dimensions, the loss cannot be reduced considerably below the loss of the metal itself unless one operates in the far IR and THz regions of the spectrum or below. Such high losses cannot be compensated by introducing gain due to Purcell-induced shortening of recombination times. The only way low loss optical meta-materials can be engineered is with, as yet unknown, low loss materials with negative permittivity.
116 citations
TL;DR: It is shown that adhesion of human ErbB2+ breast cancer cells to basement membrane laminin-5 provides substantial resistance to trastuzumab and lapatinib, agents that respectively target the extracellular and kinase domains of Erb B2.
Abstract: Resistance to anti-ErbB2 agents is a significant problem in the treatment of human ErbB2+ breast cancers. We show here that adhesion of human ErbB2+ breast cancer cells to basement membrane laminin-5 provides substantial resistance to trastuzumab and lapatinib, agents that respectively target the extracellular and kinase domains of ErbB2. Knockdown of laminin-binding integrins (alpha6beta4, alpha3beta1) or associated tetraspanin protein CD151 reversed laminin-5 resistance and sensitized ErbB2+ cells to trastuzumab and lapatinib. CD151 knockdown, together with trastuzumab treatment, inhibited ErbB2 activation and downstream signaling through Akt, Erk1/2, and focal adhesion kinase (FAK). Hence, ErbB2 function in mammary tumor cells is promoted by integrin-mediated adhesion to laminin-5, with strong support by CD151, leading to signaling through FAK. Consequently, removal or inhibition of any of these components (laminin-5, integrin, CD151, FAK) markedly sensitizes cells to anti-ErbB2 agents. These new insights should be useful when devising strategies for overcoming drug resistance in ErbB2+ cancers.
116 citations
Patent•
22 Jun 1998TL;DR: In this article, a process for extracting edible protein from animal muscle by solubilizing the protein in an alkaline aqueous solution is described, and the protein is then used for protein preservation.
Abstract: A process for isolating edible protein from animal muscle by solubilizing the protein in an alkaline aqueous solution is disclosed.
116 citations
TL;DR: In this paper, the authors propose a core-satellite model where corporate food processors link up with small farmers through production contracts, exchanging agricultural inputs and services for assured deliveries of produce.
116 citations
TL;DR: A predominant signal of increasing species richness in coastal systems since 1962 is detected in a new dataset spanning from 1962 to 2015 from marine coastal ecosystems, testing whether biodiversity changed at local scales in recent decades and whether ecological context can be ignored.
115 citations
Authors
Showing all 6667 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Derek R. Lovley | 168 | 582 | 95315 |
| Wei Li | 158 | 1855 | 124748 |
| Susan E. Hankinson | 151 | 789 | 88297 |
| Roger J. Davis | 147 | 498 | 103478 |
| Thomas P. Russell | 141 | 1012 | 80055 |
| George Alverson | 140 | 1653 | 105074 |
| Robert H. Brown | 136 | 1174 | 79247 |
| C. Dallapiccola | 136 | 1717 | 101947 |
| Paul T. Costa | 133 | 406 | 88454 |
| Robert R. McCrae | 132 | 313 | 90960 |
| David Julian McClements | 131 | 1137 | 71123 |
| Mauro Giavalisco | 128 | 412 | 69967 |
| Benjamin Brau | 128 | 971 | 72704 |
| Douglas T. Golenbock | 123 | 317 | 61267 |
| Zhifeng Ren | 122 | 695 | 71212 |