Institution
University of Massachusetts Boston
Education•Boston, Massachusetts, United States•
About: University of Massachusetts Boston is a education organization based out in Boston, Massachusetts, United States. It is known for research contribution in the topics: Population & Health care. The organization has 6541 authors who have published 12918 publications receiving 411731 citations. The organization is also known as: UMass Boston.
Papers published on a yearly basis
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TL;DR: In this article, the authors used longitudinal data from 90 parents of children with ASD to replicate and extend a prior cross-sectional study on stress proliferation by Benson (J Autism Develop Disord 36:685-695, 2006).
Abstract: Stress proliferation (the tendency for stressors to create additional stressors) has been suggested as an important contributor to depression among caregivers. The present study utilized longitudinal data from 90 parents of children with ASD to replicate and extend a prior cross-sectional study on stress proliferation by Benson (J Autism Develop Disord 36:685-695, 2006). Consistent with Benson's earlier findings, regression analyses indicated that stress proliferation mediated the effect of child symptom severity on parent depression. Parent anger was also found to mediate the effect of symptom severity on stress proliferation as well as the effect of stress proliferation on parent depression. Finally, informal social support was found to be related to decreased parent depressed mood over time. Implications of study findings are discussed.
256 citations
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TL;DR: Although there was evidence of maternal distress in both groups, the presence of significant buffering effects reflects adaptation in the face of stress, particularly for mothers of adolescents.
Abstract: The present study examined the impact of autism symptoms and coping strategies on the well-being of mothers of children with autism spectrum disorder (ASD). The sample consisted of 153 mothers of toddlers and 201 mothers of adolescents drawn from two ongoing, longitudinal studies of families of individuals with ASD. For mothers of toddlers, lower levels of emotion-focused coping and higher levels of problem-focused coping were generally associated with better maternal well-being, regardless of the level of child symptomatology. For mothers of adolescents, coping often acted as a buffer when autism symptoms were high. Although there was evidence of maternal distress in both groups, the presence of significant buffering effects reflects adaptation in the face of stress, particularly for mothers of adolescents.
255 citations
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30 Jun 1997TL;DR: In this paper, a number of minimally invasive, miniature surgical instruments are mounted directly on a surgeon's fingertips in a way that the surgeon can insert his or her hand into a patient through a minimal incision to perform surgical procedures, and also to use his or his fingers to manipulate tissues.
Abstract: The invention is a number of minimally invasive, miniature surgical instruments (10) that can be mounted directly on a surgeon's fingertips in a way that the surgeon can insert his or her hand into a patient through a minimal incision to perform surgical procedures, and also to use his or her fingers to manipulate tissues. The invention enables the surgeon to perform the procedures with all the benefits of minimally invasive surgery, but with much greater tactile sense, control, and ease of manipulation, than enabled by known minimally invasive surgical instruments.
254 citations
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TL;DR: The authors found that the practice of mindfulness is associated with healthy emotion regulation (e.g., reduced intensity of distress, enhanced emotional recovery, reduced negative self-referential processing, and/or enhanced ability to engage in goal-directed behaviors) and may play a causal role in these effects.
Abstract: One proposed pathway for the documented psychological effects of mindfulness (cultivating awareness and acceptance of the present moment) has been through its facilitation of adaptive emotion regulation (ER). Although conceptual overlap between the two constructs complicates interpretation of correlational findings, an emerging body of laboratory, experimental, and treatment outcome studies provides preliminary support of proposed conceptual models. These findings indicate that the practice of mindfulness is associated with healthy ER (e.g., reduced intensity of distress, enhanced emotional recovery, reduced negative self-referential processing, and/or enhanced ability to engage in goal-directed behaviors) and may play a causal role in these effects. More experimental and longitudinal research is needed to determine the exact nature, temporal unfolding, and causality of these associations.
254 citations
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Cardiff University1, Radboud University Nijmegen2, University of Massachusetts Boston3, University of Alberta4, Goethe University Frankfurt5, Trinity College, Dublin6, University of St Andrews7, State University of New York Upstate Medical University8, University of Trier9, University of Marburg10, University of Würzburg11, Saarland University12, University of Tübingen13, University of Zurich14, VU University Amsterdam15, Aalborg University16, Ghent University17, Harvard University18, Children's Hospital of Philadelphia19, University of Toronto20, Washington University in St. Louis21, University of California, Berkeley22, King's College London23
TL;DR: Findings support the enrichment of large, rare CNVs in ADHD and implicate duplications at 15q13.3 as a novel risk factor for ADHD.
Abstract: OBJECTIVE:
Attention deficit hyperactivity disorder (ADHD) is a common, highly heritable psychiatric disorder. Because of its multifactorial etiology, however, identifying the genes involved has been difficult. The authors followed up on recent findings suggesting that rare copy number variants (CNVs) may be important for ADHD etiology.
METHOD:
The authors performed a genome-wide analysis of large, rare CNVs (<1% population frequency) in children with ADHD (N=896) and comparison subjects (N=2,455) from the IMAGE II Consortium.
RESULTS:
The authors observed 1,562 individually rare CNVs >100 kb in size, which segregated into 912 independent loci. Overall, the rate of rare CNVs >100 kb was 1.15 times higher in ADHD case subjects relative to comparison subjects, with duplications spanning known genes showing a 1.2-fold enrichment. In accordance with a previous study, rare CNVs >500 kb showed the greatest enrichment (1.28-fold). CNVs identified in ADHD case subjects were significantly enriched for loci implicated in autism and in schizophrenia. Duplications spanning the CHRNA7 gene at chromosome 15q13.3 were associated with ADHD in single-locus analysis. This finding was consistently replicated in an additional 2,242 ADHD case subjects and 8,552 comparison subjects from four independent cohorts from the United Kingdom, the United States, and Canada. Presence of the duplication at 15q13.3 appeared to be associated with comorbid conduct disorder.
CONCLUSIONS:
These findings support the enrichment of large, rare CNVs in ADHD and implicate duplications at 15q13.3 as a novel risk factor for ADHD. With a frequency of 0.6% in the populations investigated and a relatively large effect size (odds ratio=2.22, 95% confidence interval=1.5–3.6), this locus could be an important contributor to ADHD etiology.
253 citations
Authors
Showing all 6667 results
Name | H-index | Papers | Citations |
---|---|---|---|
Derek R. Lovley | 168 | 582 | 95315 |
Wei Li | 158 | 1855 | 124748 |
Susan E. Hankinson | 151 | 789 | 88297 |
Roger J. Davis | 147 | 498 | 103478 |
Thomas P. Russell | 141 | 1012 | 80055 |
George Alverson | 140 | 1653 | 105074 |
Robert H. Brown | 136 | 1174 | 79247 |
C. Dallapiccola | 136 | 1717 | 101947 |
Paul T. Costa | 133 | 406 | 88454 |
Robert R. McCrae | 132 | 313 | 90960 |
David Julian McClements | 131 | 1137 | 71123 |
Mauro Giavalisco | 128 | 412 | 69967 |
Benjamin Brau | 128 | 971 | 72704 |
Douglas T. Golenbock | 123 | 317 | 61267 |
Zhifeng Ren | 122 | 695 | 71212 |