Institution
Vignan University
Education•Guntur, Andhra Pradesh, India•
About: Vignan University is a education organization based out in Guntur, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Control theory. The organization has 1138 authors who have published 1381 publications receiving 7798 citations.
Papers
More filters
••
TL;DR: Gene expression data revealed that SbsHsp-02 is a candidate gene expressed in all the tissues under varied stress conditions tested, which contribute to the understanding of the complexity of SBSHsp genes and help to analyse them further for functional validation.
38 citations
••
TL;DR: In this article, the authors evaluated the effect of fiber loading on hybrid composites and optimized the mechanical properties such as tensile strength, flexural strength and impact strength of the resultant hybrid composite.
38 citations
••
14 May 2018TL;DR: In this article, a photocatalytic nanocomposite system based on titania (TiO2) was proposed for photoelectrochemical (PEC) water splitting to produce hydrogen under sunlight.
Abstract: Light-driven processes such as photocatalytic environmental remediation and photoelectrochemical (PEC) water splitting to produce hydrogen under sunlight are key technologies toward energy sustainability. Despite enormous efforts, a suitable photocatalyst fulfilling all the main requirements such as high photoactivity under visible light, chemical stability, environmental friendliness, and low cost has not been found yet. A promising approach to overcome these limitations is to use hybrid nanostructures showing improved activity and physicochemical properties when compared with single components. Herein, we present a novel photocatalytic nanocomposite system based on titania (TiO2): titania nanorod wrapped with Ni(OH)2 and Cu(OH)2 composite carbon nitride (CuNi@g-C3N4/TiO2). This carefully tuned photoanode nanostructure shows almost one order of magnitude higher photocurrent density compared to unsensitized TiO2 nanorods for PEC water splitting upon solar-light illumination. The heterostructured g-C3N4 st...
38 citations
••
TL;DR: In this paper, the authors used the DE algorithm to find efficient solutions to the identified problem of generation expansion planning (GEP) for two different planning horizons of 6 and 14 years, and an approach was adopted to understand the long term impact of wind additions by imposing total emission reduction constraints (TERC) and emission treatment penalty costs (ETPC) on the remaining portion of pollution.
37 citations
••
TL;DR: Recombinant AK36 protein comprised of immunodominant antigens from outer membrane proteins (Omp’s) of Klebsiella pneumoniae namely OmpA and OmpK36 was highly immunogenic and the hyperimmune sera reacted strongly with native Omp a and OMPK36 proteins from different K. pneumoniae strains.
Abstract: Safety and protective efficacy of recombinant multi-epitopic subunit vaccine (r-AK36) comprising immunodominant antigens from outer membrane proteins (Omp’s) of Klebsiella pneumoniae namely OmpA and OmpK36 was evaluated in mouse model. r-AK36 was highly immunogenic and the hyperimmune sera reacted strongly with native OmpA and OmpK36 proteins from different K. pneumoniae strains. Hyperimmune sera showed cross reactivity with Omp’s of other Gram negative organisms. Humoral responses showed a Th2- type polarized immune response with IgG1 being the predominant antibody isotype. Anti-r-AK36 antibodies showed antimicrobial effect during in vitro MIC testing with values in range of 25-50 µg/ml on different K. pneumoniae strains. The recombinant antigen elicited three-fold higher proliferation of splenocytes from immunized mice indicating possible T-cell clonal proliferation and differentiation into effector cells. Anti-r-AK36 antibodies also exhibited in vitro biofilm inhibition property. Subunit vaccine r-AK36 immunization promoted induction of anti-inflammatory cytokines in immunized mice. When r-AK36 immunized mice were challenged with 3xLD100 dose, ~80 % of mice survived beyond the observation period. Passive antibody administration to naive mice protected them (67 %) against the lethal challenge. Since the targeted OMPs are conserved among all K. pneumoniae serovars and due to the strong nature of immune responses, r-AK36 subunit vaccine could be a safe and cost effective candidate against klebsiellosis.
37 citations
Authors
Showing all 1166 results
Name | H-index | Papers | Citations |
---|---|---|---|
Muthukaruppan Alagar | 40 | 316 | 5914 |
Ebenezer Daniel | 40 | 180 | 5597 |
P. B. Kavi Kishor | 30 | 123 | 3486 |
V. Purnachandra Rao | 26 | 59 | 1723 |
Muddu Sekhar | 24 | 135 | 1929 |
Anandarup Goswami | 23 | 44 | 5427 |
Reddymasu Sreenivasulu | 20 | 58 | 925 |
Murthy Chavali | 20 | 105 | 1699 |
Krishna P. Kota | 20 | 42 | 1172 |
Naveen Mulakayala | 17 | 39 | 937 |
Tondepu Subbaiah | 16 | 65 | 773 |
Bharat Kumar Tripuramallu | 15 | 34 | 574 |
Avireni Srinivasulu | 13 | 97 | 626 |
Abhinav Parashar | 13 | 29 | 375 |
Umesh Chandra | 13 | 39 | 550 |