Institution
Vignan University
Education•Guntur, Andhra Pradesh, India•
About: Vignan University is a education organization based out in Guntur, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Control theory. The organization has 1138 authors who have published 1381 publications receiving 7798 citations.
Papers
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TL;DR: The development of broadly reactive and cross protective Sal-06mAb opens new possibilities for immunotherapy of sepsis caused by Gram-negative Enterobacteriaceae members.
Abstract: In the present study, we have generated a murine monoclonal antibody (mAb) named Sal-06 by using the crude outer membrane protein preparation of Salmonella enteric subsp. enterica serovar Typhimurium ATCC 14028 strain as antigen. Sal-06mAb belonging to IgG1 isotype demonstrated broad cross-reactivity to standard and isolated strains of genus Salmonella and others such as Escherichia coli, Klebsiella pneumonia, and Proteus mirabilis. Cross-reactivity across several bacterial genera indicated that the epitopes reactive to Sal-06mAb are conserved among these members. Neutralizing effects of Sal-06mAb on Salmonella growth and survival was evaluated in vitro using bacteriostatic and bactericidal activity with and without complement and bacterial invasion inhibition assay. Sal-06mAb demonstrated a bacteriostatic effect on the growth of S. typhimurium ATCC 14028 strain which is both time and concentration (of mAb) dependent. It was also found that the bacterial growth inhibition was complement independent. When the bacterial cells were preincubated with Sal-06mAb, it reduced the adherence and invasion of bacterial cells into A549 epithelial cell line. This was confirmed by CFU count analysis, phase contrast, and fluorescence microscopy. Scanning electron microscope (SEM) imaging confirmed the antimicrobial effects of Sal-06mAb on S. typhimurium ATCC 14028. The development of broadly reactive and cross protective Sal-06mAb opens new possibilities for immunotherapy of sepsis caused by Gram-negative Enterobacteriaceae members.
4 citations
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TL;DR: Abutilon indicum (Malvaceae), a therapeutically valuable shrub can act as a continuous source of stigmasterol, accredited with pharmacological significance, and the content of this shrub is studied.
Abstract: Abutilon indicum (Malvaceae), a therapeutically valuable shrub can act as a continuous source of stigmasterol, accredited with pharmacological significance. In the present study, the content of sti...
4 citations
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TL;DR: In this paper, the authors used thermogravimetry analysis (TGA)/differential scanning calorimetry (DSC), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and cyclic voltammetry (CV) techniques.
4 citations
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Vignan University1, Zakir Husain Delhi College2, Indian Council of Agricultural Research3, University of Delhi4, G. B. Pant University of Agriculture and Technology5, Sardarkrushinagar Dantiwada Agricultural University6, Fiji National University7, Centurion University of Technology and Management8, University of Tabuk9, Rice University10, University of Tsukuba11, International Centre for Genetic Engineering and Biotechnology12
TL;DR: How salinity stress affects tomato plant growth and developmental processes and productivity and how ET inhibitors and polyamines as protectants reverse the negative effects of ET/salinity stress-induced cellular damage by cross talk with important physiological processes-photosynthesis and respiratory and salt overly sensitive (SOS).
Abstract: Tomato is an important crop and has immense health benefits and medicinal value. Here, we described how salinity stress affects tomato plant growth and developmental processes and productivity. It ...
4 citations
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TL;DR: In this paper, the effect of naringenin (4,5,7-trihydroxy flavonone) on the pharmacokinetics of metoprolol, a substrate of Cytochrome P-450 3A4 (CYP3A4), CYP2C9, and CYP 2D6 in rats was investigated.
Abstract: The aim of the present study was to investigate the effect of naringenin (4,5,7-trihydroxy flavonone) on the pharmacokinetics of metoprolol, a substrate of Cytochrome P-450 3A4 (CYP3A4), CYP2C9, and CYP2D6 in rats. Male Wistar rats were treated orally with metoprolol (30 mg/kg) alone and in combination with naringenin (25, 50, and 100 mg/kg) once daily for 15 consecutive days. The plasma concentrations of metoprolol were determined using Reverse Phase-High Performance Liquid Chromatography (RP-HPLC) on the 1st day in single-dose pharmacokinetic (PK) study (SDS) and on the 15th day in multiple dosing PK studies (MDS). Compared to the metoprolol control group, the Cmax, AUC, and half-life (T1/2) of metoprolol increased in rats pre-treated with naringenin, while there was no significant change in Tmax. There is a significant decrease in clearance and volume of distribution. The present study results revealed that naringenin significantly enhanced the Cmax, AUC, MRT, t1/2, and decreased the clearance of metoprolol possibly through the inhibition of CYP enzymes involved in the metabolism of metoprolol.
4 citations
Authors
Showing all 1166 results
Name | H-index | Papers | Citations |
---|---|---|---|
Muthukaruppan Alagar | 40 | 316 | 5914 |
Ebenezer Daniel | 40 | 180 | 5597 |
P. B. Kavi Kishor | 30 | 123 | 3486 |
V. Purnachandra Rao | 26 | 59 | 1723 |
Muddu Sekhar | 24 | 135 | 1929 |
Anandarup Goswami | 23 | 44 | 5427 |
Reddymasu Sreenivasulu | 20 | 58 | 925 |
Murthy Chavali | 20 | 105 | 1699 |
Krishna P. Kota | 20 | 42 | 1172 |
Naveen Mulakayala | 17 | 39 | 937 |
Tondepu Subbaiah | 16 | 65 | 773 |
Bharat Kumar Tripuramallu | 15 | 34 | 574 |
Avireni Srinivasulu | 13 | 97 | 626 |
Abhinav Parashar | 13 | 29 | 375 |
Umesh Chandra | 13 | 39 | 550 |