Institution
Vignan University
Education•Guntur, Andhra Pradesh, India•
About: Vignan University is a education organization based out in Guntur, Andhra Pradesh, India. It is known for research contribution in the topics: Computer science & Control theory. The organization has 1138 authors who have published 1381 publications receiving 7798 citations.
Papers
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TL;DR: The current status, various strategies and advantages of pharmaceutical protein production in plant expression systems, as well as a summary of expression of therapeutic monoclonal antibodies, vaccines, clinical trials and the regulatory aspects of plant-based expression are presented.
Abstract: There is an increasing demand for the generation of recombinant pharmaceutical proteins for a wide array of therapeutic applications. In comparison to bacterial, yeast and animal cells, the production of recombinant proteins in plants with economic and therapeutic importance has only started recently. The most important prerequisite of any expression systems is that it should be simple and inexpensive. In this regard, plant-based expression has emerged an as accepted alternative to conventional expression platforms due to economic feasibility, rapid scalability, higher stability of recombinant proteins, safety due to lack of harmful substances (human, animal pathogens and pyrogens) and capability of producing proteins with desired secondary modifications. Heterologous expression using plants has played a pivotal role in the development of a myriad of recombinant proteins, including neutraceuticals and monoclonal antibodies being utilized in various therapeutic approaches. This paper presents an overview about the current status, various strategies and advantages of pharmaceutical protein production in plant expression systems. We also present a summary of expression of therapeutic monoclonal antibodies, vaccines, clinical trials and the regulatory aspects of plant-based expression. Furthermore, the challenges encountered in plant expression such as costs associated with existing purification strategies are discussed.
35 citations
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Vignan University1, University of Montpellier2, University of Naples Federico II3, Central Agricultural University4, Indian Council of Agricultural Research5, Jaypee University of Information Technology6, National Scientific and Technical Research Council7, University of São Paulo8, University of Vigo9
TL;DR: In this paper, the authors illustrated the feedstocks used for biodiesel production such as vegetable oils, non-edible oils, oleaginous microalgae, fungi, yeast, and bacteria.
Abstract: Biodiesel is an eco-friendly, renewable, and potential liquid biofuel mitigating greenhouse gas emissions. Biodiesel has been produced initially from vegetable oils, non-edible oils, and waste oils. However, these feedstocks have several disadvantages such as requirement of land and labor and remain expensive. Similarly, in reference to waste oils, the feedstock content is succinct in supply and unable to meet the demand. Recent studies demonstrated utilization of lignocellulosic substrates for biodiesel production using oleaginous microorganisms. These microbes accumulate higher lipid content under stress conditions, whose lipid composition is similar to vegetable oils. In this paper, feedstocks used for biodiesel production such as vegetable oils, non-edible oils, oleaginous microalgae, fungi, yeast, and bacteria have been illustrated. Thereafter, steps enumerated in biodiesel production from lignocellulosic substrates through pretreatment, saccharification and oleaginous microbe-mediated fermentation, lipid extraction, transesterification, and purification of biodiesel are discussed. Besides, the importance of metabolic engineering in ensuring biofuels and biorefinery and a brief note on integration of liquid biofuels have been included that have significant importance in terms of circular economy aspects.
35 citations
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TL;DR: The results have confirmed that green synthesis of AgNPs leads to the fabrication of sphere-shaped particles with a diameter of 53 nm, which has demonstrated its potential as a novel biomaterial which can be used for various biomedical applications.
Abstract: The aim of this study was to perform green synthesis of silver nanoparticles (AgNPs) from the leaf extract of Desmostachya bipinnata (Dharba), a medicinally important herb which is widely used acro...
35 citations
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01 Jan 201934 citations
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TL;DR: In this article, the authors investigated the two-dimensional natural convection and entropy generation within a hollow heat exchanger, which is filled with CuO-water nanofluid which its dynamic viscosity is estimated by KKL model.
33 citations
Authors
Showing all 1166 results
Name | H-index | Papers | Citations |
---|---|---|---|
Muthukaruppan Alagar | 40 | 316 | 5914 |
Ebenezer Daniel | 40 | 180 | 5597 |
P. B. Kavi Kishor | 30 | 123 | 3486 |
V. Purnachandra Rao | 26 | 59 | 1723 |
Muddu Sekhar | 24 | 135 | 1929 |
Anandarup Goswami | 23 | 44 | 5427 |
Reddymasu Sreenivasulu | 20 | 58 | 925 |
Murthy Chavali | 20 | 105 | 1699 |
Krishna P. Kota | 20 | 42 | 1172 |
Naveen Mulakayala | 17 | 39 | 937 |
Tondepu Subbaiah | 16 | 65 | 773 |
Bharat Kumar Tripuramallu | 15 | 34 | 574 |
Avireni Srinivasulu | 13 | 97 | 626 |
Abhinav Parashar | 13 | 29 | 375 |
Umesh Chandra | 13 | 39 | 550 |