A functional heteromeric MIF receptor formed by CD74 and CXCR4.
Verena Schwartz,Hongqi Lue,Sandra Kraemer,Joanna Korbiel,Regina M. Krohn,Kim Ohl,Richard Bucala,Christian Weber,Jürgen Bernhagen +8 more
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It is shown that CXCR4 and CD74 colocalize by fluorescence microscopy and are related to each other by the H2O2/O2 “spiking” signal.About:
This article is published in FEBS Letters.The article was published on 2009-09-03 and is currently open access. It has received 192 citations till now. The article focuses on the topics: Macrophage migration inhibitory factor & Protein kinase B.read more
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A guide to chemokines and their receptors.
TL;DR: This guide gives a broad overview of the chemokines and chemokine receptor families; summarizes the complex physical interactions that occur in theChemokine network; and, using specific examples, discusses general principles of Chemokine function, focusing particularly on their ability to direct leukocyte migration.
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Astaxanthin: A mechanistic review on its biological activities and health benefits.
TL;DR: A novel hypothesis is suggested for the mechanism of action of AST in neuropathic pain following spinal cord injury and the therapeutic potentials, biological activities and benefical health effects of AST are focused on.
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Cystic fibrosis sputum DNA has NETosis characteristics and neutrophil extracellular trap release is regulated by macrophage migration-inhibitory factor.
Markryan Dwyer,Qiang Shan,Samantha D'Ortona,Rie Maurer,Robert A. Mitchell,Hanne Olesen,Steffen Thiel,Johannes Huebner,Mihaela Gadjeva +8 more
TL;DR: It is suggested that targeting MIF by small molecular inhibitors might reduce the presence of extracellular DNA and serve as an adjunct to the use of antimicrobial drugs that could ultimately reduce bacterial fitness in the lungs during the later stages of CF disease.
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Diversity and Inter-Connections in the CXCR4 Chemokine Receptor/Ligand Family: Molecular Perspectives.
TL;DR: Insight is provided into the diversity and inter-connections in the CXCR4 receptor/ligand family and the atypical chemokine macrophage migration inhibitory factor (MIF) was identified as an alternative, non-cognate ligand for CxCR4 and shown to mediate chemotaxis and arrest of CX CR4-expressing T-cells.
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The multifaceted roles of the invariant chain CD74--More than just a chaperone
TL;DR: An overview of the diverse biological functions of the CD74 protein is provided with a particular focus on how these may be regulated and proteolysis of CD74 will be discussed as a central mechanism to control the actions of this important protein at different levels.
References
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International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
William A. Catterall,K. G. Chandy,David E. Clapham,George A. Gutman,Franz Hofmann,Anthony J. Harmar,Darrell R. Abernethy,Michael Spedding +7 more
TL;DR: This issue of Pharmacological Reviews includes a new venture in the collaboration between the International Union of Pharmacology (IUPHAR) and the American Society for Pharmacology and Experimental Therapeutics (ASPET), in that a new classification of voltage-gated ion channels is outlined.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Chemokines and leukocyte traffic
TL;DR: Over the past ten years, numerous chemokines have been identified as attractants of different types of blood leukocytes to sites of infection and inflammation and are now known to also function as regulatory molecules in leukocyte maturation, traffic and homing of lymphocytes, and the development of lymphoid tissues.
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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Daniel J. Ceradini,Anita R Kulkarni,Matthew J. Callaghan,Oren M. Tepper,Nicholas Bastidas,Mark E. Kleinman,Jennifer M. Capla,Robert D. Galiano,Jamie P. Levine,Geoffrey C. Gurtner +9 more
TL;DR: It is shown that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of S DF-1 in ischemic tissue in direct proportion to reduced oxygen tension.
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Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
Takashi Nagasawa,Seiichi Hirota,Kazunobu Tachibana,Nobuyuki Takakura,Shin-Ichi Nishikawa,Yukihiko Kitamura,Nobuaki Yoshida,Hitoshi Kikutani,Tadamitsu Kishimoto +8 more
TL;DR: It is shown that the chemokine PBSF/SDF-1 has several essential functions in development, including B-cell lymphopoiesis and bone-marrow myelopoiedis and a cardiac ventricular septal defect.
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