A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
Ulrike Burk,Joerg Schubert,Ulrich F. Wellner,Otto Schmalhofer,Elizabeth Vincan,Simone Spaderna,Thomas Brabletz +6 more
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TLDR
Results indicate that ZEB1 triggers an microRNA‐mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells, and thus explain the strong intratumorous heterogeneity observed in many human cancers.Abstract:
The embryonic programme 'epithelial-mesenchymal transition' (EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc-finger E-box binding homeobox 1 (ZEB1) is a crucial inducer of EMT in various human tumours, and was recently shown to promote invasion and metastasis of tumour cells. Here, we report that ZEB1 directly suppresses transcription of microRNA-200 family members miR-141 and miR-200c, which strongly activate epithelial differentiation in pancreatic, colorectal and breast cancer cells. Notably, the EMT activators transforming growth factor beta2 and ZEB1 are the predominant targets downregulated by these microRNAs. These results indicate that ZEB1 triggers an microRNA-mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells. Alternatively, depending on the environmental trigger, this loop might switch and induce epithelial differentiation, and thus explain the strong intratumorous heterogeneity observed in many human cancers.read more
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Identification of miR-200c-3p as a major regulator of SaoS2 cells activation induced by fluoride.
TL;DR: It is found that NaF promoted SaoS2 proliferation and activation by activating BMP4/Smad pathway and suggested an important regulatory role of miR-200c-3p on B MP4/ Smad pathway during skeletal fluorosis.
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MicroRNA-200a induces apoptosis by targeting ZEB2 in alcoholic liver disease.
Yu-xin Zhao,Yu-xin Zhao,Ying-Yin Sun,Ying-Yin Sun,Ai-Ling Huang,Ai-Ling Huang,Xiao-Feng Li,Xiao-Feng Li,Cheng Huang,Cheng Huang,Taotao Ma,Taotao Ma,Jun Li,Jun Li +13 more
TL;DR: It is demonstrated that miR-200a regulates the apoptosis of hepatocyte in ALD by directly target ZEB2, both of which could serve as new therapeutic targets for ALD.
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Relation between microRNA expression in peritoneal dialysis effluent and peritoneal transport characteristics.
Jin Chen,Philip Kam-Tao,Bonnie Ching-Ha Kwan,Kai-Ming Chow,Ka-Bik Lai,Cathy Choi-Wan Luk,Cheuk-Chun Szeto +6 more
TL;DR: The result suggests that miRNA may play a role in the regulation of peritoneal membrane function.
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Therapeutic potential of cancer stem cells
TL;DR: The biomarkers of CSCs to predict clinical outcome and their diagnostic potential are discussed and the different approaches of C SC therapies are reviewed, including cytotoxic, radiation, differentiation and targeting signaling pathways.
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miR-128 Regulates Tumor Cell CD47 Expression and Promotes Anti-tumor Immunity in Pancreatic Cancer.
Qing Xi,Ying Chen,Guangze Yang,Jieyou Zhang,Lijuan Zhang,Xiangdong Guo,Jingyi Zhao,Zhenyi Xue,Yan Li,Rongxin Zhang,Rongxin Zhang +10 more
TL;DR: Analysis of the immune microenvironment demonstrated that overexpression of miR-128 on tumor cells could increase the percentages of dendritic cells (DCs), CD8+ T lymphocytes, and natural killer T cells (NKT) in the tumor and spleen, consequently enhancing anti-tumor immunity.
References
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