A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
Ulrike Burk,Joerg Schubert,Ulrich F. Wellner,Otto Schmalhofer,Elizabeth Vincan,Simone Spaderna,Thomas Brabletz +6 more
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TLDR
Results indicate that ZEB1 triggers an microRNA‐mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells, and thus explain the strong intratumorous heterogeneity observed in many human cancers.Abstract:
The embryonic programme 'epithelial-mesenchymal transition' (EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc-finger E-box binding homeobox 1 (ZEB1) is a crucial inducer of EMT in various human tumours, and was recently shown to promote invasion and metastasis of tumour cells. Here, we report that ZEB1 directly suppresses transcription of microRNA-200 family members miR-141 and miR-200c, which strongly activate epithelial differentiation in pancreatic, colorectal and breast cancer cells. Notably, the EMT activators transforming growth factor beta2 and ZEB1 are the predominant targets downregulated by these microRNAs. These results indicate that ZEB1 triggers an microRNA-mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells. Alternatively, depending on the environmental trigger, this loop might switch and induce epithelial differentiation, and thus explain the strong intratumorous heterogeneity observed in many human cancers.read more
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MicroRNAs: Emerging oncogenic and tumor-suppressive regulators, biomarkers and therapeutic targets in lung cancer.
Shengjie Tang,Shuangjiang Li,Shuangjiang Li,Liu Tao,Yiwei He,Haiyang Hu,Zhu Yunhe,Shoujun Tang,Haining Zhou +8 more
TL;DR: In this article, a review summarizes the most recent progress on the functional mechanisms of microRNAs involved in lung cancer development and progression and further discusses the clinical application of miRNAs as putative therapeutic targets for molecular diagnosis and prognostic prediction.
Journal ArticleDOI
ZEB1 limits adenoviral infectability by transcriptionally repressing the Coxsackie virus and Adenovirus Receptor
Markus D. Lacher,Markus D. Lacher,Marisa Shiina,Peter Chang,Debora Keller,Debora Keller,Maarit Tiirikainen,Maarit Tiirikainen,W. Michael Korn +8 more
TL;DR: Evidence is provided that inhibition of ZEB1 may improve adenovirus uptake of cancer cells that have undergone EMT and for which ZEB2 is necessary to maintain the mesenchymal phenotype and TGF-β may inhibit CAR expression by regulating factor(s) that cooperate with Z EB1 to repress the CAR promoter.
Journal ArticleDOI
Positive feedback loop of lncRNA HOXC-AS2/miR-876-5p/ZEB1 to regulate EMT in glioma.
TL;DR: It is concluded that HOXC-AS2/miR-876-5p/ZEB1 constitutes a positive feedback loop to regulate EMT in GBM, providing a potential therapeutic target for glioma.
Journal ArticleDOI
The mir-200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves.
Shohreh Maleki,Shohreh Maleki,K. A. Cottrill,Flore-Anne Poujade,Flore-Anne Poujade,Anirban Bhattachariya,Anirban Bhattachariya,Otto Bergman,Otto Bergman,Jesper R. Gådin,Jesper R. Gådin,Nancy Simon,Nancy Simon,Karin Lundströmer,Karin Lundströmer,Anders Franco-Cereceda,Anders Franco-Cereceda,Hanna M. Björck,Hanna M. Björck,S. Y. Chan,Per Eriksson,Per Eriksson +21 more
TL;DR: This work investigated the still incompletely described role of microRNAs (miRNAs), important post‐transcriptional regulators of gene expression, in such aortic disease of patients with BAV as compared with TAV.
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The interplay between microRNAs and Twist1 transcription factor: a systematic review.
TL;DR: This systematic review was conducted to clarify the reciprocal link between Twist1 and miRNAs in order to provide potential candidate mi RNAs for diagnostic and therapeutic approaches in cancer treatment.
References
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