A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
Ulrike Burk,Joerg Schubert,Ulrich F. Wellner,Otto Schmalhofer,Elizabeth Vincan,Simone Spaderna,Thomas Brabletz +6 more
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TLDR
Results indicate that ZEB1 triggers an microRNA‐mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells, and thus explain the strong intratumorous heterogeneity observed in many human cancers.Abstract:
The embryonic programme 'epithelial-mesenchymal transition' (EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc-finger E-box binding homeobox 1 (ZEB1) is a crucial inducer of EMT in various human tumours, and was recently shown to promote invasion and metastasis of tumour cells. Here, we report that ZEB1 directly suppresses transcription of microRNA-200 family members miR-141 and miR-200c, which strongly activate epithelial differentiation in pancreatic, colorectal and breast cancer cells. Notably, the EMT activators transforming growth factor beta2 and ZEB1 are the predominant targets downregulated by these microRNAs. These results indicate that ZEB1 triggers an microRNA-mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells. Alternatively, depending on the environmental trigger, this loop might switch and induce epithelial differentiation, and thus explain the strong intratumorous heterogeneity observed in many human cancers.read more
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MicroRNAs Contribute to Breast Cancer Invasiveness.
TL;DR: Recent data on breast cancer-specific miRNA expression profiles and their participation in regulating invasive processes, in association with changes in cytoskeletal structure, cell-cell adhesion junctions, cancer cell-extracellular matrix interactions, tumor microenvironments, epithelial-to-mesenchymal transitions and cancer cell stem abilities are summarized.
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Emerging role of tumor cell plasticity in modifying therapeutic response
Siyuan Qin,Jingwen Jiang,Yi Lu,Edouard C. Nice,Canhua Huang,Canhua Huang,Jian Zhang,Weifeng He +7 more
TL;DR: Over the years, understanding of the emerging role of phenotype switching in modifying therapeutic response has considerably increased, and expanded knowledge of tumor cell plasticity contributes to developing novel therapeutic strategies or combination therapy regimens using available anticancer drugs, which are likely to improve patient outcomes in clinical practice.
Journal ArticleDOI
A Long Non-coding RNA Activated by Transforming Growth Factor-β is an Independent Prognostic Marker of Gastric Cancer.
Tomoko Saito,Junji Kurashige,Sho Nambara,Hisateru Komatsu,Hidenari Hirata,Masami Ueda,Shotaro Sakimura,Ryutaro Uchi,Yuki Takano,Yoshiaki Shinden,Tomohiro Iguchi,Hidetoshi Eguchi,Shogo Ehata,Kazunari Murakami,Keishi Sugimachi,Koshi Mimori +15 more
TL;DR: LncRNA-ATB plays an important role in EMT to promote invasion and metastasis through the TGF-β/miR-200s/ZEB axis, resulting in a poor prognosis in GC patients.
Journal ArticleDOI
The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymal transition in pulmonary epithelial cells
Mitsuhiro Yamada,Hiroshi Kubo,Chiharu Ota,Toru Takahashi,Yukiko Tando,Takaya Suzuki,Naoya Fujino,Tomonori Makiguchi,Kiyoshi Takagi,Takashi Suzuki,Masakazu Ichinose +10 more
TL;DR: MicroRNA-21 was significantly upregulated in isolated lung epithelial cells during bleomycin-induced lung fibrosis and human idiopathic pulmonary fibrosis, and it promotes epithelial-mesenchymal transition.
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MicroRNA Regulation of Human Breast Cancer Stem Cells
TL;DR: A set of miRNAs differentially expressed between human breast cancer stem cells (CSCs) and non-tumorigenic cancer cells is identified and clarifying the miRNA regulation of the metastatic breast CSCs will further advance the understanding of the roles of human breast C SCs in tumor progression.
References
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