A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
Ulrike Burk,Joerg Schubert,Ulrich F. Wellner,Otto Schmalhofer,Elizabeth Vincan,Simone Spaderna,Thomas Brabletz +6 more
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TLDR
Results indicate that ZEB1 triggers an microRNA‐mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells, and thus explain the strong intratumorous heterogeneity observed in many human cancers.Abstract:
The embryonic programme 'epithelial-mesenchymal transition' (EMT) is thought to promote malignant tumour progression. The transcriptional repressor zinc-finger E-box binding homeobox 1 (ZEB1) is a crucial inducer of EMT in various human tumours, and was recently shown to promote invasion and metastasis of tumour cells. Here, we report that ZEB1 directly suppresses transcription of microRNA-200 family members miR-141 and miR-200c, which strongly activate epithelial differentiation in pancreatic, colorectal and breast cancer cells. Notably, the EMT activators transforming growth factor beta2 and ZEB1 are the predominant targets downregulated by these microRNAs. These results indicate that ZEB1 triggers an microRNA-mediated feedforward loop that stabilizes EMT and promotes invasion of cancer cells. Alternatively, depending on the environmental trigger, this loop might switch and induce epithelial differentiation, and thus explain the strong intratumorous heterogeneity observed in many human cancers.read more
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Regulation of miR-200c/141 expression by intergenic DNA-looping and transcriptional read-through
Luciana Batista,Luciana Batista,Brigitte Bourachot,Brigitte Bourachot,Bogdan Mateescu,Bogdan Mateescu,Fabien Reyal,Fatima Mechta-Grigoriou,Fatima Mechta-Grigoriou +8 more
TL;DR: The miR-200c/141 transcription is intimately linked to the transcription of the proximal upstream gene PTPN6 (SHP1) in all physiological conditions tested and highlights that transcription of intergenic miRNAs is a novel outcome of transcriptional read-through.
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Epigenetic regulators of programmed death-ligand 1 expression in human cancers.
TL;DR: Recent findings and evidence on epigenetic mechanisms that regulate PD‐L1 expression and the biological and clinical implications of such regulation in cancer are reviewed.
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Radiogenomic Analysis Demonstrates Associations between (18)F-Fluoro-2-Deoxyglucose PET, Prognosis, and Epithelial-Mesenchymal Transition in Non-Small Cell Lung Cancer.
Shota Yamamoto,Danshan Huang,Liutao Du,Ronald L. Korn,Neema Jamshidi,Barry L. Burnette,Michael D. Kuo +6 more
TL;DR: Investigating whether non-small cell lung cancer tumors that express high normalized maximum standardized uptake value (SUVmax) are associated with a more epithelial-mesenchymal transition (EMT)-like phenotype demonstrates an association between increased normalized fluoro-2-deoxyglucose PET SUVmax, outcome, and EMT in NSCLC.
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Epithelial–mesenchymal transition in Crohn’s disease
TL;DR: Current knowledge of epithelial–mesenchymal transition and its role in the pathogenesis of CD is presented in order to highlight new therapy targets for the associated complications.
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Lung cancer and miRNAs: a possible remedy for anti-metastatic, therapeutic and diagnostic applications
TL;DR: The recent advances made in the understanding of the miRNAs with special reference to lung cancer are summarized and different kinds of them would be discussed to delineate their significance in lung cancer biology, therapy and diagnosis.
References
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Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Jing Yang,Sendurai A. Mani,Joana Liu Donaher,Sridhar Ramaswamy,Sridhar Ramaswamy,Raphael Itzykson,Christophe Côme,Pierre Savagner,Inna Gitelman,Andrea L. Richardson,Robert A. Weinberg +10 more
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