A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment
Minoti V. Apte,Jeremy S. Wilson,Aurelia Lugea,Aurelia Lugea,Stephen J. Pandol,Stephen J. Pandol,Stephen J. Pandol +6 more
TLDR
The background and recent advances in pancreatic cancer research began to change with the identification of pancreatic stellate cells, which produce the pancreatic tumor stroma, along with important areas of future research that could improve therapy.About:
This article is published in Gastroenterology.The article was published on 2013-05-01 and is currently open access. It has received 366 citations till now. The article focuses on the topics: Pancreatic cancer & Pancreatic tumor.read more
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Journal ArticleDOI
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Daniel Öhlund,Daniel Öhlund,Daniel Öhlund,Abram Handly-Santana,Abram Handly-Santana,Giulia Biffi,Giulia Biffi,Ela Elyada,Ela Elyada,Ana S. Almeida,Ana S. Almeida,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Mariano Ponz-Sarvise,Vincenzo Corbo,Tobiloba E. Oni,Tobiloba E. Oni,Tobiloba E. Oni,Stephen Hearn,Eun Jung Lee,Eun Jung Lee,Iok In Christine Chio,Iok In Christine Chio,Chang-Il Hwang,Chang-Il Hwang,Hervé Tiriac,Hervé Tiriac,Lindsey A. Baker,Lindsey A. Baker,Dannielle D. Engle,Dannielle D. Engle,Christine Feig,Anne Kultti,Mikala Egeblad,Douglas T. Fearon,James M. Crawford,Hans Clevers,Young-Kyu Park,Young-Kyu Park,David A. Tuveson,David A. Tuveson +40 more
TL;DR: Direct evidence for CAF heterogeneity in PDA tumor biology is provided, providing direct evidence for disease etiology and therapeutic development in mouse and human PDA tissue.
Journal ArticleDOI
Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma
Abasi Ene–Obong,Andrew Clear,Jennifer Watt,Jennifer Watt,Jun Wang,Rewas Fatah,John Riches,John Marshall,Jo-Anne Chin Aleong,Claude Chelala,John G. Gribben,Alan G. Ramsay,Hemant M. Kocher,Hemant M. Kocher +13 more
TL;DR: Based on studies of human PDAC samples and KPC mice, activated PSCs appear to reduce migration of CD8(+) T cells to juxtatumoral stromal compartments, preventing their access to cancer cells.
Journal ArticleDOI
Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
Matteo Ligorio,Srinjoy Sil,Jose Malagon-Lopez,Linda T. Nieman,Sandra Misale,Mauro Di Pilato,Richard Y. Ebright,Murat Karabacak,Anupriya S. Kulkarni,A. W. K. Liu,Nicole Vincent Jordan,Joseph W. Franses,Julia Philipp,Johannes Kreuzer,Niyati Desai,Kshitij S. Arora,Mihir Rajurkar,Elad Horwitz,Azfar Neyaz,Eric Tai,Neelima K.C. Magnus,Kevin D. Vo,Chittampalli Yashaswini,Francesco Marangoni,Myriam Boukhali,Jackson P. Fatherree,Leah J. Damon,Kristina Xega,Rushil Desai,Melissa Choz,Francesca Bersani,Adam Langenbucher,Vishal Thapar,Robert Morris,Ulrich F. Wellner,Oliver Schilling,Michael S. Lawrence,Andrew S. Liss,Miguel Rivera,Vikram Deshpande,Cyril H. Benes,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber,Carlos Fernandez-del-Castillo,Cristina R. Ferrone,Wilhelm Haas,Martin J. Aryee,David T. Ting +48 more
TL;DR: The impact of the stroma is demonstrated in shaping tumor architecture by altering inherent patterns of tumor glands in human PDAC by quantifying EMT and PRO subpopulations in 319,626 individual cancer cells that can be classified within the context of distinct tumor gland "units".
Journal Article
Trp53R172H and kmsg12d cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
Sunil R. Hingorani,Lifu Wang,Asha S. Multani,Chelsea Combs,Therese B. Deramaudt,Ralph H. Hruban,Anil K. Rustgi,Sandy Chang,David A. Tuveson +8 more
TL;DR: In this article, the authors defined the genetic requirements for pancreatic ductal adenocarcinoma (PDA) and targeted concomitant endogenous expression of Trp53 R172H and Kras G12D to reveal the cooperative development of invasive and widely metastatic carcinoma that recapitulates the human disease.
Journal ArticleDOI
Pancreatic Cancer Chemoresistance to Gemcitabine.
Manoj Amrutkar,Ivar P. Gladhaug +1 more
TL;DR: To circumvent gem citabine resistance in PDAC, several novel therapeutic approaches, including chemical modifications of the gemcitabine molecule generating numerous new prodrugs, as well as new entrapment designs of gemcitABine in colloidal systems such as nanoparticles and liposomes, are currently being investigated.
References
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Book
Physiology of the Gastrointestinal Tract
TL;DR: Physiology of the Gastrointestinal Tract, Fifth Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine.
Journal ArticleDOI
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
TL;DR: In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner.
Journal ArticleDOI
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
Journal ArticleDOI
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
Sunil R. Hingorani,Lifu Wang,Asha S. Multani,Chelsea Combs,Therese B. Deramaudt,Ralph H. Hruban,Anil K. Rustgi,Sandy Chang,David A. Tuveson +8 more
TL;DR: Targeted concomitant endogenous expression of Trp53(R172H) and Kras(G12D) to the mouse pancreas reveals the cooperative development of invasive and widely metastatic carcinoma that recapitulates the human disease.
Journal ArticleDOI
Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance
TL;DR: Plasma IL-6 was significantly higher in obese subjects and demonstrated a highly significant inverse relationship with S(I) (r = -0.71, P < 0.001), while plasma TNF was significantly associated with plasma nonesterified fatty acid levels (r=0.49, P = 0.002).
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