Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption
Guoxiang Xie,Wei Zhong,Houkai Li,Qiong Li,Yunping Qiu,Xiaojiao Zheng,Huiyuan Chen,Xueqing Zhao,Shucha Zhang,Zhanxiang Zhou,Steven H. Zeisel,Wei Jia +11 more
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TLDR
An improved understanding of the systemic modulations of bile acid metabolism in mammals through the gut‐liver axis is provided.Abstract:
Our understanding of the bile acid metabolism is limited by the fact that previous analyses have primarily focused on a selected few circulating bile acids; the bile acid profiles of the liver and gastrointestinal tract pools are rarely investigated. Here, we determined how chronic ethanol consumption altered the bile acids in multiple body compartments (liver, gastrointestinal tract, and serum) of rats. Rats were fed a modified Lieber-DeCarli liquid diet with 38% of calories as ethanol (the amount equivalent of 4-5 drinks in humans). While conjugated bile acids predominated in the liver (98.3%), duodenum (97.8%), and ileum (89.7%), unconjugated bile acids comprised the largest proportion of measured bile acids in serum (81.2%), the cecum (97.7%), and the rectum (97.5%). In particular, taurine-conjugated bile acids were significantly decreased in the liver and gastrointestinal tract of ethanol-treated rats, while unconjugated and glycine-conjugated species increased. Ethanol consumption caused increased expression of genes involved in bile acid biosynthesis, efflux transport, and reduced expression of genes regulating bile acid influx transport in the liver. These results provide an improved understanding of the systemic modulations of bile acid metabolism in mammals through the gut-liver axis.read more
Citations
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The gut–liver axis and the intersection with the microbiome
Anupriya Tripathi,Anupriya Tripathi,Justine W. Debelius,David A. Brenner,Michael Karin,Rohit Loomba,Bernd Schnabl,Bernd Schnabl,Rob Knight +8 more
TL;DR: Gut–liver communications in liver disease is reviewed, exploring the molecular, genetic and microbiome relationships and discussing prospects for exploiting the microbiome to determine liver disease stage and to predict the effects of pharmaceutical, dietary and other interventions at a population and individual level.
Journal ArticleDOI
Interactions between the intestinal microbiome and liver diseases.
Bernd Schnabl,David A. Brenner +1 more
TL;DR: The contribution of the intestinal microbiome to liver disease goes beyond simple translocation of bacterial products that promote hepatic injury and inflammation and is reviewed to ensure that microbial metabolites produced in a dysbiotic intestinal environment and host factors are equally important in the pathogenesis of liver disease.
Journal ArticleDOI
Intestinal microbiota contributes to individual susceptibility to alcoholic liver disease
M. Llopis,Anne-Marie Cassard,Laura Wrzosek,L. Boschat,A Bruneau,Gladys Ferrere,Virginie Puchois,Jean-Charles Martin,Patricia Lepage,T Le Roy,L Lefèvre,B Langelier,F. Cailleux,A M González-Castro,Sylvie Rabot,Françoise Gaudin,Hélène Agostini,Sophie Prevot,Dominique Berrebi,Dragos Ciocan,Cyril Jousse,Sylvie Naveau,Philippe Gérard,Gabriel Perlemuter +23 more
TL;DR: Individual susceptibility to ALD is substantially driven by IM and it may be possible to prevent and manage ALD by IM manipulation, as demonstrated by mice humanised with the IM from an sAH patient.
Journal ArticleDOI
Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.
Siamak Mahmoudiandehkordi,Matthias Arnold,Kwangsik Nho,Shahzad Ahmad,Wei Jia,Wei Jia,Guoxiang Xie,Gregory Louie,Alexandra Kueider-Paisley,M. Arthur Moseley,J. Will Thompson,Lisa St John Williams,Jessica D. Tenenbaum,Colette Blach,Rebecca Baillie,Xianlin Han,Sudeepa Bhattacharyya,Jon B. Toledo,Simon Schafferer,Sebastian Klein,Therese Koal,Shannon L. Risacher,Mitchel A. Kling,Alison A. Motsinger-Reif,Daniel M. Rotroff,John Jack,Thomas Hankemeier,David A. Bennett,Philip L. De Jager,John Q. Trojanowski,Leslie M. Shaw,Michael W. Weiner,P. Murali Doraiswamy,Cornelia M. van Duijn,Andrew J. Saykin,Gabi Kastenmüller,Rima Kaddurah-Daouk +36 more
TL;DR: This data indicates that BAs, products of cholesterol metabolism and clearance, are produced in the liver and are further metabolized by gut bacteria and seem dysregulated in Alzheimer's disease (AD).
Journal ArticleDOI
Fecal microbiota manipulation prevents dysbiosis and alcohol-induced liver injury in mice
Gladys Ferrere,Laura Wrzosek,Frédéric Cailleux,Williams Turpin,Williams Turpin,Virginie Puchois,Madeleine Spatz,Dragos Ciocan,Dominique Rainteau,Lydie Humbert,Lydie Humbert,Lydie Humbert,Cindy Hugot,Françoise Gaudin,Marie-Louise Noordine,Véronique Robert,Dominique Berrebi,Muriel Thomas,Sylvie Naveau,Gabriel Perlemuter,Anne-Marie Cassard +20 more
TL;DR: Manipulation of IM can prevent alcohol-induced liver injury and the IM should be considered as a new therapeutic target in ALD.
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Jonathan R. Swann,Elizabeth J. Want,Florian M. Geier,Konstantina Spagou,Ian D. Wilson,James E. Sidaway,Jeremy K. Nicholson,Elaine Holmes +7 more
TL;DR: The presence of specific microbial bile acid co-metabolite patterns in peripheral tissues (including heart and kidney) implies a broader signaling role for these compounds and emphasizes the extent of symbiotic microbial influences in mammalian homeostasis.