Changes in Gut Microbiota after a Four-Week Intervention with Vegan vs. Meat-Rich Diets in Healthy Participants: A Randomized Controlled Trial.
Eva Kohnert,Clemens Kreutz,Nadine Binder,Luciana Hannibal,Gregor Gorkiewicz,Alexander Müller,Maximilian Andreas Storz,Roman Huber,Ann-Kathrin Lederer +8 more
- Vol. 9, Iss: 4, pp 727
TLDR
In this paper, a 4-week, monocentric, randomized, controlled trial with a parallel group design (vegan (VD) vs. meat-rich (MD)) with 53 healthy, omnivore, normal-weight participants (62% female, mean 31 years of age), fecal samples were collected at the beginning and at the end of the trial and were analyzed using 16S rRNA gene amplicon sequencing (Clinical Trial register: DRKS00011963).Abstract:
An essential role of the gut microbiota in health and disease is strongly suggested by recent research. The composition of the gut microbiota is modified by multiple internal and external factors, such as diet. A vegan diet is known to show beneficial health effects, yet the role of the gut microbiota is unclear. Within a 4-week, monocentric, randomized, controlled trial with a parallel group design (vegan (VD) vs. meat-rich (MD)) with 53 healthy, omnivore, normal-weight participants (62% female, mean 31 years of age), fecal samples were collected at the beginning and at the end of the trial and were analyzed using 16S rRNA gene amplicon sequencing (Clinical Trial register: DRKS00011963). Alpha diversity as well as beta diversity did not differ significantly between MD and VD. Plotting of baseline and end samples emphasized a highly intra-individual microbial composition. Overall, the gut microbiota was not remarkably altered between VD and MD after the trial. Coprococcus was found to be increased in VD while being decreased in MD. Roseburia and Faecalibacterium were increased in MD while being decreased in VD. Importantly, changes in genera Coprococcus, Roseburia and Faecalibacterium should be subjected to intense investigation as markers for physical and mental health.read more
Citations
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A Vegan Diet Is Associated with a Significant Reduction in Dietary Acid Load: Post Hoc Analysis of a Randomized Controlled Trial in Healthy Individuals
Alexander Müller,Amy Marisa Zimmermann-Klemd,Ann-Kathrin Lederer,Luciana Hannibal,Stefanie Kowarschik,Roman Huber,Maximilian Andreas Storz +6 more
TL;DR: In this paper, a randomized controlled trial was conducted to examine whether an isocaloric vegan diet lowers dietary acid load (DAL) as compared to a meat-rich diet, which was determined using potential renal acid load and net endogenous acid production (NEAP) scores at baseline and after 3 and 4 weeks.
Journal ArticleDOI
Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options
TL;DR: The global incidence of numerous immune-mediated, metabolic, neurodegenerative, and psychiatric diseases is steadily increasing and the number of confirmed cases is increasing.
Journal ArticleDOI
Bowel Health in U.S. Vegetarians: A 4-Year Data Report from the National Health and Nutrition Examination Survey (NHANES)
TL;DR: The lack of an association of vegetarian status and bowel health is surprising, and may be a result of the relatively low fiber intake in this particular vegetarian cohort, which did not meet the daily fiber recommendations.
Journal ArticleDOI
Polyphenols and Small Phenolic Acids as Cellular Metabolic Regulators
TL;DR: The role of polyphenols and select phenolic compounds as metabolic or intrinsic biochemistry regulators are explored in the context of the microbiota–gut–target organ axis in health and disease.
Journal ArticleDOI
Analysis of S-Adenosylmethionine and S-Adenosylhomocysteine: Method Optimisation and Profiling in Healthy Adults upon Short-Term Dietary Intervention
Aida Corrillero Bravo,Maria Nieves Ligero Aguilera,Nahuel R. Marziali,Lennart Moritz,Victoria Wingert,Katharina Klotz,Anke Schumann,Sarah C. Grünert,Ute Spiekerkoetter,Urs Berger,Ann-Kathrin Lederer,Roman Huber,Luciana Hannibal +12 more
TL;DR: Plasma and urinary SAM and SAH concentrations were determined for the first time in a randomised controlled trial of 53 healthy adult omnivores before and after a 4 week intervention with a vegan or meat-rich diet, and preserved variations of both metabolites and the SAM/SAH index.
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TL;DR: QIIME 2 development was primarily funded by NSF Awards 1565100 to J.G.C. and R.K.P. and partial support was also provided by the following: grants NIH U54CA143925 and U54MD012388.
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TL;DR: Three robust clusters (referred to as enterotypes hereafter) are identified that are not nation or continent specific and confirmed in two published, larger cohorts, indicating that intestinal microbiota variation is generally stratified, not continuous.