Clonal integration of a polyomavirus in human Merkel cell carcinoma.
TLDR
In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells, and MCV may be a contributing factor in the pathogenesis of MCC.Abstract:
Merkel cell carcinoma (MCC) is a rare but aggressive human skin cancer that typically affects elderly and immunosuppressed individuals, a feature suggestive of an infectious origin. We studied MCC samples by digital transcriptome subtraction and detected a fusion transcript between a previously undescribed virus T antigen and a human receptor tyrosine phosphatase. Further investigation led to identification and sequence analysis of the 5387-base-pair genome of a previously unknown polyomavirus that we call Merkel cell polyomavirus (MCV or MCPyV). MCV sequences were detected in 8 of 10 (80%) MCC tumors but only 5 of 59 (8%) control tissues from various body sites and 4 of 25 (16%) control skin tissues. In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells. Thus, MCV may be a contributing factor in the pathogenesis of MCC.read more
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Expression of TdT in Merkel cell carcinoma and small cell lung carcinoma.
Michael Sidiropoulos,Wedad Hanna,Wedad Hanna,Simon J. Raphael,Simon J. Raphael,Zeina Ghorab,Zeina Ghorab +6 more
TL;DR: TdT may be beneficial in rare cases of CK20- MCC and may assist in distinguishing between M CC and SCLC, and there is significant immunohistochemical variability and overlap between these 2 tumors.
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Understanding Microbe-Induced Cancers
TL;DR: A classification system is proposed that highlights common and proposed microbe-induced pathways toward oncogenesis, with an emphasis on types of targeted cells and host-microbial interactions.
Journal ArticleDOI
The Role of Merkel Cell Polyomavirus and Other Human Polyomaviruses in Emerging Hallmarks of Cancer
TL;DR: This review elaborates on the putative roles of human polyomaviruses in some of the emerging hallmarks of cancer, including inhibiting tumor suppressors, activating tumor promoters, preventing apoptosis, inducing angiogenesis and stimulating metastasis.
Journal ArticleDOI
New respiratory viruses and the elderly.
Laura Jartti,Henriikka Langen,Maria Söderlund-Venermo,Tytti Vuorinen,Olli Ruuskanen,Tuomas Jartti +5 more
TL;DR: These new respiratory viruses discovered since 1997 are introduced and their clinical significance is reviewed, especially with regard to the elderly population.
Journal Article
The novel KI, WU, MC polyomaviruses: Possible human pathogens?
TL;DR: The discovery of M CPyV in a rare and aggressive skin cancer named Merckel cell carcinoma and its clonal integration within the tumor genome suggests that MCPyV infection may represent an early event in the pathogenesis of this disease.
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