Cohort Profile: The INMA—INfancia y Medio Ambiente—(Environment and Childhood) Project
Mònica Guxens,Ferran Ballester,Mercedes Espada,Mariana F. Fernández,Joan O. Grimalt,Jesús Ibarluzea,Nicolás Olea,Marisa Rebagliato,Adonina Tardón,Maties Torrent,Jesús Vioque,Martine Vrijheid,Jordi Sunyer +12 more
TLDR
This study aims to demonstrate the efforts towards in-situ applicability of EMMARM, as to provide real-time information about infectious disease and its effects on individual patients.Abstract:
Centre for Research in Environmental Epidemiology, 08003 Barcelona, Catalonia, Spain, Municipal Institute of Medical Research (IMIM), 08003 Barcelona, Catalonia, Spain, CIBER Epidemiologı́a y Salud Pública (CIBERESP), 08003 Barcelona, Spain, Division of Environment and Health, Centre for Public Health Research-CSISP, 46020 Valencia, Spain, School of Nursing, University of Valencia, 46010 Valencia, Spain, Departamento de Sanidad Gobierno Vasco, Laboratorio Normativo de Salud Pública, 48010 Bilbao, Spain, Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, 18012 Granada, Spain, Department of Environmental Chemistry, IDÆA-CSIC, 08034 Barcelona, Catalonia, Spain, Departamento de Sanidad Gobierno Vasco, Subdirección de Salud Pública de Guipúzcoa, 20013 San Sebastián, Spain, Departmento de Salud Pública, Universidad Miguel Hernández, 03550 San Juan de Alicante, Spain, University of Oviedo, 33006 Oviedo, Spain, IB-Salut Menorca Health Area, 07701 Mao, Menorca, Balearic Islands, Spain, Fundació Caubet-CIMERA, 07110 Bunyola, Mallorca, Balearic Islands, Spain and Pompeu Fabra University, 08003 Barcelona, Catalonia, Spainread more
Citations
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Journal ArticleDOI
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Bonnie R. Joubert,Janine F. Felix,Paul Yousefi,Kelly M. Bakulski,Allan C. Just,Carrie V. Breton,Sarah E. Reese,Christina A. Markunas,Christina A. Markunas,Rebecca C Richmond,Cheng-Jian Xu,Leanne K. Küpers,Sam S. Oh,Cathrine Hoyo,Olena Gruzieva,Cilla Söderhäll,Lucas A. Salas,Nour Baïz,Hongmei Zhang,Johanna Lepeule,Carlos Ruiz,Symen Ligthart,Tianyuan Wang,Jack A. Taylor,Liesbeth Duijts,Gemma C Sharp,Soesma A Jankipersadsing,Roy Miodini Nilsen,Ahmad Vaez,Ahmad Vaez,M. Daniele Fallin,Donglei Hu,Augusto A. Litonjua,Bernard F. Fuemmeler,Karen Huen,Juha Kere,Inger Kull,Monica Cheng Munthe-Kaas,Ulrike Gehring,Mariona Bustamante,Marie José Saurel-Coubizolles,Bilal M. Quraishi,Jie Ren,Jörg Tost,Juan R. González,Marjolein J. Peters,Siri E. Håberg,Zongli Xu,Joyce B. J. van Meurs,Tom R. Gaunt,Marjan Kerkhof,Eva Corpeleijn,Andrew P. Feinberg,Celeste Eng,Andrea A. Baccarelli,Sara E. Benjamin Neelon,Asa Bradman,Simon Kebede Merid,Anna Bergström,Zdenko Herceg,Hector Hernandez-Vargas,Bert Brunekreef,Mariona Pinart,Barbara Heude,Susan Ewart,Jin Yao,Nathanaël Lemonnier,Oscar H. Franco,Michael C. Wu,Albert Hofman,Albert Hofman,Wendy L. McArdle,Pieter van der Vlies,Fahimeh Falahi,Matthew W. Gillman,Lisa F. Barcellos,Ashok Kumar,Ashok Kumar,Ashok Kumar,Magnus Wickman,Magnus Wickman,Stefano Guerra,Marie-Aline Charles,John W. Holloway,Charles Auffray,Henning Tiemeier,George Davey Smith,Dirkje S. Postma,Marie-France Hivert,Brenda Eskenazi,Martine Vrijheid,Hasan Arshad,Josep M. Antó,Abbas Dehghan,Wilfried Karmaus,Isabella Annesi-Maesano,Jordi Sunyer,Akram Ghantous,Göran Pershagen,Nina Holland,Susan K. Murphy,Dawn L. DeMeo,Esteban G. Burchard,Christine Ladd-Acosta,Harold Snieder,Wenche Nystad,Gerard H. Koppelman,Caroline L Relton,Vincent W. V. Jaddoe,Allen J. Wilcox,Erik Melén,Erik Melén,Stephanie J. London +112 more
TL;DR: This large scale meta-analysis of methylation data identified numerous loci involved in response to maternal smoking in pregnancy with persistence into later childhood and provide insights into mechanisms underlying effects of this important exposure.
A genome-wide association meta-analysis identifies new childhood obesity loci
Jonathan P. Bradfield,H. Rob Taal,Nicholas J. Timpson,André Scherag,Cécile Lecoeur,Nicole M. Warrington,Elina Hyppönen,Claus Holst,Beatriz Valcarcel,Elisabeth Thiering,Rany M. Salem,Fredrick R. Schumacher,Diana L. Cousminer,Patrick M. A. Sleiman,Jianhua Zhao,Robert I. Berkowitz,Karani Santhanakrishnan Vimaleswaran,Ivonne Jarick,Craig E. Pennell,David M. Evans,Beate St Pourcain,Diane J. Berry,Dennis O. Mook-Kanamori,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Cornelia M. van Duijn,Ralf J. P. van der Valk,Johan C. de Jongste,Dirkje S. Postma,Dorret I. Boomsma,W. James Gauderman,Mohamed T. Hassanein,Cecilia M. Lindgren,Reedik Mägi,Colin Boreham,Charlotte E. Neville,Luis A. Moreno,Paul Elliott,Anneli Pouta,Anna-Liisa Hartikainen,Mingyao Li,Olli T. Raitakari,Terho Lehtimäki,Johan G. Eriksson,Aarno Palotie,Jean Dallongeville,Shikta Das,Panos Deloukas,George McMahon,Susan M. Ring,John P. Kemp,Jessica L. Buxton,Alexandra I. F. Blakemore,Mariona Bustamante,Mònica Guxens,Joel N. Hirschhorn,Matthew W. Gillman,Eskil Kreiner-Møller,Hans Bisgaard,Frank D. Gilliland,Joachim Heinrich,Eleanor Wheeler,Inês Barroso,Stephen O'Rahilly,Aline Meirhaeghe,Thorkild I. A. Sørensen,Chris Power,Lyle J. Palmer,Anke Hinney,Elisabeth Widen,I. Sadaf Farooqi,Mark I. McCarthy,Philippe Froguel,David Meyre,Johannes Hebebrand,Marjo-Riitta Järvelin,Vincent W. V. Jaddoe,George Davey Smith,Hakon Hakonarson,Struan F.A. Grant +80 more
Journal ArticleDOI
The Human Early-Life Exposome (HELIX): Project Rationale and Design
Martine Vrijheid,Rémy Slama,Oliver Robinson,Leda Chatzi,Muireann Coen,Peter van den Hazel,Cathrine Thomsen,John Wright,Toby J. Athersuch,Narcis Avellana,Xavier Basagaña,Céline Brochot,Luca Bucchini,Mariona Bustamante,Angel Carracedo,Maribel Casas,Xavier Estivill,Lesley Fairley,Diana van Gent,Juan R. González,Berit Granum,Regina Gražulevičienė,Kristine B. Gutzkow,Jordi Julvez,Hector C. Keun,Manolis Kogevinas,Rosemary R. C. McEachan,Helle Margrete Meltzer,Eduard Sabidó,Per E. Schwarze,Valérie Siroux,Jordi Sunyer,Elizabeth J. Want,Florence Anna Zeman,Mark J. Nieuwenhuijsen +34 more
TL;DR: HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood, and will form an important first step toward the life-course exposomes.
Journal ArticleDOI
Reproducibility and validity of a food frequency questionnaire among pregnant women in a Mediterranean area
Jesús Vioque,Eva-María Navarrete-Muñoz,Daniel Gimenez-Monzo,Manuela García-de-la-Hera,Fernando Granado,Ian S. Young,Rosa Ramón,Ferran Ballester,Mario Murcia,Marisa Rebagliato,Carmen Iñiguez +10 more
TL;DR: This study supports that the FFQ has a good reproducibility for nutrient and food intake, and can provide a valid estimate of several important nutrients during pregnancy.
Journal ArticleDOI
Developmental PBDE Exposure and IQ/ADHD in Childhood: A Systematic Review and Meta-analysis
Juleen Lam,Bruce P. Lanphear,David C. Bellinger,Daniel A. Axelrad,Jennifer McPartland,Patrice Sutton,Lisette Davidson,Natalyn Daniels,Saunak Sen,Tracey J. Woodruff +9 more
TL;DR: There was sufficient evidence supporting an association between developmental PBDE exposure and reduced IQ, and the body of evidence was of “moderate” quality for ADHD with “limited” evidence for an association with PBDEs.
References
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Mediterranean diet in pregnancy is protective for wheeze and atopy in childhood
Leda Chatzi,M. Torrent,Isabelle Romieu,Raquel Garcia-Esteban,Carlos Ferrer,Jesús Vioque,Manolis Kogevinas,Manolis Kogevinas,Jordi Sunyer,Jordi Sunyer +9 more
TL;DR: A protective effect of a high level of adherence to a Mediterranean diet during pregnancy against asthma-like symptoms and atopy in childhood is found.
Journal ArticleDOI
Human exposure to endocrine-disrupting chemicals and prenatal risk factors for cryptorchidism and hypospadias: a nested case-control study
Mariana F. Fernández,Begoña Olmos,Alicia Granada,Maria-Jose Lopez-Espinosa,José-Manuel Molina-Molina,Juan Manuel Fernandez,M. Cruz,Fátima Olea-Serrano,Nicolás Olea +8 more
TL;DR: An increased risk for male urogenital malformations related to the combined effect of environmental estrogens in placenta is found, and engagement of mothers in agriculture and history of previous stillbirths were associated with risk of malformation.
Journal ArticleDOI
Maternal fish intake during pregnancy and atopy and asthma in infancy
Isabelle Romieu,M. Torrent,Raquel Garcia-Esteban,Carlos Ferrer,N. Ribas-Fitó,Josep M. Antó,Josep M. Antó,Jordi Sunyer,Jordi Sunyer +8 more
TL;DR: This data indicates that intake of n‐3 fatty acids during pregnancy could play a role in the risk of asthma and atopy in the offspring.
Journal ArticleDOI
Maternal smoking habits and cognitive development of children at age 4 years in a population-based birth cohort
TL;DR: An association with maternal smoking during pregnancy and lowered cognitive development in children at age 4 years is suggested.
Journal ArticleDOI
Breastfeeding, Exposure to Organochlorine Compounds, and Neurodevelopment in Infants
Núria Ribas-Fitó,E Cardo,Maria Sala,M Eulalia De Muga,Carlos Mazón,Antoni Verdú,Manolis Kogevinas,Joan O. Grimalt,Jordi Sunyer +8 more
TL;DR: Prenatal exposure to p,p'DDE was associated with a delay in mental and psychomotor development at 13 months and long-term breastfeeding was found to be beneficial to neurodevelopment, potentially counterbalancing the impact of exposure to these chemicals through breast milk.