Journal ArticleDOI
Crossing borders: linking environmental and genetic developmental factors.
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Please cite this paper as: Joles (2011).Abstract:
Please cite this paper as: Joles (2011). Crossing Borders: Linking Environmental and Genetic Developmental Factors. Microcirculation 18(4), 298–303.
Abstract
Besides the impact of direct environmental factors, the occurrence of non-communicable adult disease is determined by non-genetic and genetic developmental factors. The broad developmental categories, developmental programing and genetic variation are often viewed as being independent of each other. The object of this review, focusing on hypertension and hypercholesterolemia, is to identify interaction between genetic and non-genetic developmental factors influencing risk factors that can contribute to the occurrence of non-communicable adult disease.read more
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Associations of Maternal Prepregnancy Body Mass Index and Gestational Weight Gain With Adult Offspring Cardiometabolic Risk Factors The Jerusalem Perinatal Family Follow-Up Study
Hagit Hochner,Yechiel Friedlander,Ronit Calderon-Margalit,Vardiella Meiner,Yael Wolff Sagy,Meytal Avgil-Tsadok,Ayala Burger,Bella Savitsky,David S. Siscovick,Orly Manor +9 more
TL;DR: In this paper, the associations of maternal prepregnancy body mass index (mppBMI) and gestational weight gain (GWG) are associated with adult offspring adiposity, and whether these maternal attributes are related to other cardiometabolic risk factors in adulthood has not been comprehensively studied.
Journal ArticleDOI
Fetoplacental Vascular Endothelial Dysfunction as an Early Phenomenon in the Programming of Human Adult Diseases in Subjects Born from Gestational Diabetes Mellitus or Obesity in Pregnancy
Andrea Leiva,Fabián Pardo,Marco A. Ramírez,Marco A. Ramírez,Marcelo Farías,Paola Casanello,Luis Sobrevia +6 more
TL;DR: It is suggested that this pathological state of GDM and OP prone placental endothelium could be considered as a metabolic marker that could predict occurrence of diseases in adulthood, such as cardiovascular disease, obesity, diabetes mellitus, and metabolic syndrome.
Journal ArticleDOI
Early determinants of cardiovascular disease
TL;DR: A comprehensive overview of multiple animal models of cardiovascular programming suggests that, in analogy to what has been previously recognised in programming, many quite different reprogramming interventions all have similar protective effects.
Journal ArticleDOI
Cross-fostering: Elucidating the effects of gene×environment interactions on phenotypic development.
TL;DR: Cross‐fostering of litters from soon after birth until weaning is a valuable tool to study the ways in which gene × environment interactions program the development of neural, physiological and behavioral characteristics of mammalian species.
Journal ArticleDOI
Associations of maternal pre-pregnancy and gestational body size with offspring longitudinal change in BMI.
Gabriella M. Lawrence,Shani Shulman,Yechiel Friedlander,Colleen M. Sitlani,Ayala Burger,Bella Savitsky,Einat Granot-Hershkovitz,Thomas Lumley,Thomas Lumley,Pui-Yan Kwok,Stephanie Hesselson,Daniel A. Enquobahrie,Pandora L. Wander,Orly Manor,David S. Siscovick,Hagit Hochner +15 more
TL;DR: In this article, the association between maternal excess weight in pregnancy and offspring BMI change from adolescence to adulthood was examined, and whether associations are explained by offspring genetics was assessed by using a birth cohort of 1400 adults, with data at birth, age 17 and 32 years.
References
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Common genetic determinants of vitamin D insufficiency: a genome-wide association study
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TL;DR: In this article, a genome-wide association study of 25-hydroxyvitamin D concentrations in 33,996 individuals of European descent from 15 cohorts was conducted to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency.
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Genome-wide association study of blood pressure and hypertension
Daniel Levy,Georg Ehret,Georg Ehret,Kenneth Rice,Germaine C. Verwoert,Lenore J. Launer,Abbas Dehghan,Nicole L. Glazer,Alanna C. Morrison,Andrew D. Johnson,Thor Aspelund,Yurii S. Aulchenko,Thomas Lumley,Anna Köttgen,Ramachandran S. Vasan,Ramachandran S. Vasan,Fernando Rivadeneira,Gudny Eiriksdottir,Xiuqing Guo,Dan E. Arking,Gary F. Mitchell,Francesco U.S. Mattace-Raso,Albert V. Smith,Kent D. Taylor,Robert B. Scharpf,Shih-Jen Hwang,Eric J.G. Sijbrands,Joshua C. Bis,Tamara B. Harris,Santhi K. Ganesh,Santhi K. Ganesh,Christopher J. O'Donnell,Albert Hofman,Jerome I. Rotter,Josef Coresh,Emelia J. Benjamin,Emelia J. Benjamin,André G. Uitterlinden,Gerardo Heiss,Caroline S. Fox,Jacqueline C.M. Witteman,Eric Boerwinkle,Thomas J. Wang,Thomas J. Wang,Vilmundur Gudnason,Martin G. Larson,Martin G. Larson,Aravinda Chakravarti,Bruce M. Psaty,Bruce M. Psaty,Cornelia M. van Duijn +50 more
TL;DR: A genome-wide association study of systolic (SBP) and diastolic (DBP) blood pressure and hypertension in the CHARGE Consortium identifies 13 SNPs for SBP, 20 for DBP and 10 for hypertension at P < 4 × 10−7.
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Genome-wide association study identifies eight loci associated with blood pressure
Christopher Newton-Cheh,Christopher Newton-Cheh,Toby Johnson,Toby Johnson,Vesela Gateva,Martin D. Tobin,Murielle Bochud,Lachlan J. M. Coin,Samer S. Najjar,Jing Hua Zhao,Simon Heath,Susana Eyheramendy,Konstantinos A. Papadakis,Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Feng Zhang,Martin Farrall,Toshiko Tanaka,Toshiko Tanaka,Chris Wallace,Chris Wallace,John C. Chambers,Kay-Tee Khaw,Peter M. Nilsson,Pim van der Harst,Silvia Polidoro,Diederick E. Grobbee,N. Charlotte Onland-Moret,N. Charlotte Onland-Moret,Michiel L. Bots,Louise V. Wain,Katherine S. Elliott,Alexander Teumer,Jian'an Luan,Gavin Lucas,Johanna Kuusisto,Paul Burton,David Hadley,Wendy L. McArdle,Morris J. Brown,Anna F. Dominiczak,Stephen Newhouse,Nilesh J. Samani,John Webster,Eleftheria Zeggini,Eleftheria Zeggini,Jacques S. Beckmann,Sven Bergmann,Sven Bergmann,Noha Lim,Kijoung Song,Peter Vollenweider,Gérard Waeber,Dawn M. Waterworth,Xin Yuan,Leif Groop,Marju Orho-Melander,Alessandra Allione,Alessandra Di Gregorio,Simonetta Guarrera,Salvatore Panico,Fulvio Ricceri,Valeria Romanazzi,Carlotta Sacerdote,Paolo Vineis,Inês Barroso,Manjinder S. Sandhu,Manjinder S. Sandhu,Robert Luben,Gabriel Crawford,Pekka Jousilahti,Markus Perola,Markus Perola,Michael Boehnke,Lori L. Bonnycastle,Francis S. Collins,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Timo T. Valle,Cristen J. Willer,Richard N. Bergman,Mario A. Morken,Angela Döring,Christian Gieger,Thomas Illig,Thomas Meitinger,Elin Org,Arne Pfeufer,H.-Erich Wichmann,Sekar Kathiresan,Sekar Kathiresan,Jaume Marrugat,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen M. Schwartz,David S. Siscovick,Isaac Subirana,Nelson B. Freimer,Anna-Liisa Hartikainen,Mark I. McCarthy,Paul F. 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Potter,Rathi Ravindrarajan,Pamela Whittaker,David Withers,David Bentley,David Bentley,Christopher J. Groves,Audrey Duncanson,Willem H. Ouwehand,Willem H. Ouwehand,James P. Boorman,James P. Boorman,Barbera Cant,Jennifer Jolley,Alexandra S. Knight,Kerstin Koch,Niall C. Taylor,Nicholas A. Watkins,Nicholas A. Watkins,Thilo Winzer,Peter S. Braund,Richard J. Dixon,Massimo Mangino,Suzanne Stevens,Peter Donnely,Dan Davidson,Jonathan Marchini,I. C.A. Spencer,Niall Cardin,Teresa Ferreira,Joanne Pereira-Gale,Ingeleif B. Hallgrimsdottir,Bryan Howie,Zhan Su,Damjan Vukcevic,Doug Easton,Ursula Everson,Judith M. Hussey,Elizabeth Meech,Christopher Prowse,Graham R. Walters,Richard Jones,Susan M. Ring,Marcus Prembey,Marcus Prembey,Gerome Breen,David St Clair,Sian Ceasar,Katherine Gordon-Smith,Katherine Gordon-Smith,Lisa Jones,Lisa Jones,Elaine K. Green,Detelinea Grozeva,Marian L. 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Perry,Michael N. Weedon,Andrew T. Hattersley,Beverley M. Shields,Graham A. Hitman,Mark Walker,Melanie J. Newport,Giorgio Sirugo,David J. Conway,Muminatou Jallow,Linda A. Bradbury,Jennifer L. Pointon,Matthew A. Brown,Matthew A. Brown,C Farrar,Paul Wordsworth,Jayne A. Franklyn,Joanne M. Heward,Matthew J. Simmonds,Stephen C.L. Cough,Sheila Seal,Michael R. Stratton,Nazneen Rahman,An Goris,Stephen Sawcer,Alastair Compston +362 more
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Journal ArticleDOI
CATs and HATs: the SLC7 family of amino acid transporters
François Verrey,Ellen I. Closs,Carsten A. Wagner,Manuel Palacín,Hitoshi Endou,Yoshikatsu Kanai +5 more
TL;DR: Members of the CAT family transport essentially cationic amino acids by facilitated diffusion with differential trans-stimulation by intracellular substrates and may regulate the rate of NO synthesis by controlling the uptake of l-arginine as the substrate for nitric oxide synthase (NOS).