Journal ArticleDOI
Crosstalk between ER stress and immunogenic cell death.
Oliver Kepp,Laurie Menger,Laurie Menger,Laurie Menger,Erika Vacchelli,Erika Vacchelli,Erika Vacchelli,Clara Locher,Clara Locher,Sandy Adjemian,Sandy Adjemian,Sandy Adjemian,Takahiro Yamazaki,Takahiro Yamazaki,Isabelle Martins,Isabelle Martins,Isabelle Martins,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Michael Michaud,Michael Michaud,Michael Michaud,Laura Senovilla,Laura Senovilla,Laura Senovilla,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Laurence Zitvogel +29 more
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TLDR
Recent findings in the field of ICD research are summarized with a special focus on ER stress mechanisms and their implication for cancer therapy.About:
This article is published in Cytokine & Growth Factor Reviews.The article was published on 2013-08-01. It has received 134 citations till now. The article focuses on the topics: Immunogenic cell death & Unfolded protein response.read more
Citations
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Journal ArticleDOI
Consensus guidelines for the detection of immunogenic cell death
Oliver Kepp,Laura Senovilla,Ilio Vitale,Erika Vacchelli,Sandy Adjemian,Patrizia Agostinis,Lionel Apetoh,Fernando Aranda,Vincenzo Barnaba,Norma Bloy,Laura Bracci,Karine Breckpot,David Brough,Aitziber Buqué,Maria G. Castro,Mara Cirone,María Isabel Colombo,Isabelle Cremer,Sandra Demaria,Luciana Dini,Aristides G. Eliopoulos,Alberto Faggioni,Silvia C. Formenti,Jitka Fucikova,Lucia Gabriele,Udo S. Gaipl,Jérôme Galon,Abhishek D. Garg,François Ghiringhelli,Nathalia A. Giese,Zong Sheng Guo,Akseli Hemminki,Martin Herrmann,James W. Hodge,Stefan Holdenrieder,Jamie Honeychurch,Hong-Min Hu,Xing Huang,Timothy M Illidge,Koji Kono,Mladen Korbelik,Dmitri V. Krysko,Sherene Loi,Pedro R. Lowenstein,Enrico Lugli,Yuting Ma,Frank Madeo,Angelo A. Manfredi,Isabelle Martins,Domenico Mavilio,Laurie Menger,Nicolò Merendino,Michael Michaud,Grégoire Mignot,Karen L. Mossman,Gabriele Multhoff,Rudolf Oehler,Fabio Palombo,Theocharis Panaretakis,Jonathan Pol,Enrico Proietti,Jean-Ehrland Ricci,Chiara Riganti,Patrizia Rovere-Querini,Anna Rubartelli,Antonella Sistigu,Mark J. Smyth,Juergen Sonnemann,Radek Spisek,John Stagg,Abdul Qader Sukkurwala,Eric Tartour,Andrew Thorburn,Stephen H. Thorne,Peter Vandenabeele,Francesca Velotti,Samuel T Workenhe,Haining Yang,Wei-Xing Zong,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi +81 more
TL;DR: Strategies conceived to detect surrogate markers of ICD in vitro and to screen large chemical libraries for putative I CD inducers are outlined, based on a high-content, high-throughput platform that was recently developed.
Journal ArticleDOI
Systems biology of cisplatin resistance: past, present and future
Lorenzo Galluzzi,Ilio Vitale,Judith Michels,Catherine Brenner,Gyorgy Szabadkai,A Harel-Bellan,Maria Castedo,Guido Kroemer +7 more
TL;DR: Recent systems biology studies aimed at deconvoluting the complex circuitries that underpin cisplatin resistance are discussed, and how their findings might drive the development of rational approaches to tackle this clinically relevant problem.
Journal ArticleDOI
Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death.
Wei Li,Jie Yang,Lihua Luo,Mengshi Jiang,Bing Qin,Hang Yin,Chunqi Zhu,Xiaoling Yuan,Junlei Zhang,Zhenyu Luo,Yong-Zhong Du,Qingpo Li,Yan Lou,Yunqing Qiu,Jian You +14 more
TL;DR: ER-targeting PDT-PTT promoted ICD-associated immunotherapy through direct ROS-based ER stress and exhibited enhanced anti-tumour efficacy.
Journal ArticleDOI
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer
TL;DR: The tumorigenic and immunoregulatory effects of ER stress in cancer are discussed, and the concept of targeting ER stress responses to enhance the efficacy of standard chemotherapies and evolving cancer immunotherAPies in the clinic is explored.
Journal ArticleDOI
Massively Evoking Immunogenic Cell Death by Focused Mitochondrial Oxidative Stress using an AIE Luminogen with a Twisted Molecular Structure.
Chao Chen,Xiang Ni,Shaorui Jia,Yong Liang,Xiaoli Wu,Deling Kong,Deling Kong,Dan Ding,Dan Ding +8 more
TL;DR: It is revealed that inducing focused mitochondrial oxidative stress is a highly effective strategy to evoke abundant and large‐scale ICD.
References
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Journal ArticleDOI
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron,Peter Walter +1 more
TL;DR: Together, at least three mechanistically distinct arms of the UPR regulate the expression of numerous genes that function within the secretory pathway but also affect broad aspects of cell fate and the metabolism of proteins, amino acids and lipids.
Journal ArticleDOI
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Michael C. Wei,Michael C. Wei,Wei-Xing Zong,Emily H. Cheng,Tullia Lindsten,Vily Panoutsakopoulou,Andrea J. Ross,Kevin A. Roth,Grant R. MacGregor,Craig B. Thompson,Stanley J. Korsmeyer +10 more
TL;DR: In this article, the authors found that doubly deficient cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.
Journal ArticleDOI
Mitochondrial Membrane Permeabilization in Cell Death
TL;DR: Once MMP has been induced, it causes the release of catabolic hydrolases and activators of such enzymes (including those of caspases) from mitochondria, meaning that mitochondria coordinate the late stage of cellular demise.
Journal ArticleDOI
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
TL;DR: The cloning of perk is described, a gene encoding a type I transmembrane ER-resident protein that contains a protein-kinase domain most similar to that of the known eIF2α kinases, PKR and HRI that implicate PERK in a signalling pathway that attenuates protein translation in response to ER stress.
Journal ArticleDOI
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
TL;DR: Insight is provided into the regulatory mechanisms and signalling crosstalk of the three branches of the UPR, which are initiated by the stress sensors protein kinase RNA-like ER kinase (PERK), inositol-requiring protein 1α (IRE1α) and activating transcription factor 6 (ATF6).
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