Detection of Succinate by Intestinal Tuft Cells Triggers a Type 2 Innate Immune Circuit.
Marija S. Nadjsombati,John W. McGinty,Miranda R. Lyons-Cohen,James B. Jaffe,Lucian DiPeso,Christoph Schneider,Corey N. Miller,Joshua L. Pollack,G. A. Nagana Gowda,Mary F. Fontana,David J. Erle,Mark S. Anderson,Richard M. Locksley,Daniel Raftery,Jakob von Moltke +14 more
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TLDR
It is shown that detection of the microbial metabolite succinate by tuft cells in the small intestine is sufficient to induce a type 2 immune response, suggesting that tuFT cells monitor microbial metabolites to initiate type 2 immunity.About:
This article is published in Immunity.The article was published on 2018-07-17 and is currently open access. It has received 300 citations till now. The article focuses on the topics: Tuft cell & Type 2 immune response.read more
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Pathway paradigms revealed from the genetics of inflammatory bowel disease.
TL;DR: IBD is described as a model disease in the context of leveraging human genetics to dissect interactions in cellular and molecular pathways that regulate homeostasis of the mucosal immune system and future prospects for disease-subtype classification and therapeutic intervention are discussed.
Journal ArticleDOI
Epithelial cell–derived cytokines: more than just signaling the alarm
TL;DR: An overview of TSLP, IL-33, and IL-25 and the development of blocking antibodies that target these epithelial cell–derived cytokines is provides an overview of these central regulators of type 2 immunity.
Journal ArticleDOI
Coupling Krebs cycle metabolites to signalling in immunity and cancer.
Dylan G. Ryan,Michael P. Murphy,Christian Frezza,Hiran A. Prag,Edward T. Chouchani,Luke A. J. O'Neill,Evanna L. Mills +6 more
TL;DR: This review summarizes the non-metabolic signalling mechanisms of succinate, fumarate, itaconate, 2-hydroxyglutarate isomers and acetyl-CoA in both immune cells and cancer cells.
Journal ArticleDOI
Organoids in immunological research
TL;DR: How organoids are being used in immunological research to understand the role of epithelial cell–immune cell interactions in tissue development and homeostasis, as well as in diseases such as cancer is discussed.
Journal ArticleDOI
Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons
Adriana Forero,Snehal Ozarkar,Hongchuan Li,Chia Heng Lee,Emily A. Hemann,Marija S. Nadjsombati,Matthew R. Hendricks,Lomon So,Richard Green,Chandra Nath Roy,Saumendra N. Sarkar,Jakob von Moltke,Stephen K. Anderson,Michael Gale,Ram Savan +14 more
TL;DR: It is suggested that IFN receptor compartmentalization and abundance confer a spatiotemporal division of labor where type III IFNs control viral spread at the site of the infection while restricting tissue damage; the transient induction of inflammatory responses by type I IFNs recruits immune effectors to promote protective immunity.
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Succinate is an inflammatory signal that induces IL-1β through HIF-1α
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