Journal ArticleDOI
Downregulation of plasma miR-451 and miR-16 in Plasmodium vivax infection.
Supat Chamnanchanunt,Chieri Kuroki,Varunee Desakorn,Mari Enomoto,Vipa Thanachartwet,Duangjai Sahassananda,Jetsumon Sattabongkot,Rachaneeporn Jenwithisuk,Suthat Fucharoen,Saovaros Svasti,Tsukuru Umemura,Tsukuru Umemura +11 more
TLDR
Analysis of plasma miRNAs obtained from malaria patients and normal subjects suggests that plasma miR-451 and miR -16 are relevant biomarkers for malaria infection.About:
This article is published in Experimental Parasitology.The article was published on 2015-08-01. It has received 48 citations till now. The article focuses on the topics: Plasmodium vivax & Malaria.read more
Citations
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Journal ArticleDOI
miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis
Carmen Elena Condrat,Dana Claudia Thompson,Madalina Gabriela Barbu,Oana Larisa Bugnar,Andreea Elena Boboc,Dragos Cretoiu,Nicolae Suciu,Sanda Maria Cretoiu,Silviu Cristian Voinea +8 more
TL;DR: There is promising evidence that in spite of the lack of standardized protocols regarding the use of miRNA in current clinical practice, they constitute a reliable tool for future use, and it is anticipated that miRNAs will become a routine approach in the development of personalized patient profiles, thus permitting more specific therapeutic interventions.
Journal ArticleDOI
Circulating MicroRNAs as Biomarkers for Sepsis
TL;DR: The current findings on the role of circulating miRNAs in the diagnosis and staging of sepsis in critically ill patients are summarized and the challenges and drawbacks that currently prevent the use of circulatingmiRNAs as biomarkers in clinical routine are highlighted.
Journal ArticleDOI
Circulating MicroRNAs: Potential and Emerging Biomarkers for Diagnosis of Human Infectious Diseases
TL;DR: The use of miRNA as an emerging tool for the identification of the human infectious disease is highlighted and has the potential to become a powerful non-invasive biomarker in coming future.
Journal ArticleDOI
MicroRNAs: Biological Regulators in Pathogen-Host Interactions.
TL;DR: The biological aspects of microRNAs are reviewed, focusing on their roles as regulators of gene expression during pathogen–host interactions and their implications in the immune response against Leishmania, Trypanosoma, Toxoplasma, and Plasmodium infectious diseases.
Journal ArticleDOI
Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure.
Tara L. Croston,Ajay P. Nayak,Angela R. Lemons,William T. Goldsmith,Ja Kook Gu,Dori R. Germolec,Donald H. Beezhold,Brett J. Green +7 more
TL;DR: Personal exposure to fungal bioaerosols derived from contaminated building materials or agricultural commodities may induce or exacerbate a variety of adverse health effects.
References
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Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
Circulating microRNAs as stable blood-based markers for cancer detection
Patrick S. Mitchell,Rachael K. Parkin,Evan M. Kroh,Brian R. Fritz,Brian R. Fritz,Stacia K. Wyman,Era L. Pogosova-Agadjanyan,Amelia Peterson,Jennifer Noteboom,Kathy O'Briant,April Allen,Daniel W. Lin,Daniel W. Lin,Daniel W. Lin,Nicole Urban,Charles W. Drescher,Beatrice S. Knudsen,Derek L. Stirewalt,Robert Gentleman,Robert L. Vessella,Robert L. Vessella,Peter S. Nelson,Daniel Martin,Daniel Martin,Muneesh Tewari +24 more
TL;DR: It is shown here that miRNAs are present in human plasma in a remarkably stable form that is protected from endogenous RNase activity and established the measurement of tumor-derived mi RNAs in serum or plasma as an important approach for the blood-based detection of human cancer.
Journal ArticleDOI
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
Xi Chen,Yi Ba,Lijia Ma,Lijia Ma,Xing Cai,Yuan Yin,Kehui Wang,Jigang Guo,Yujing Zhang,Jiangning Chen,Xing Guo,Qibin Li,Qibin Li,Xiaoying Li,Wenjing Wang,Yan Zhang,Jin Wang,Xueyuan Jiang,Yang Xiang,Chen Xu,Pingping Zheng,Juanbin Zhang,Ruiqiang Li,Hongjie Zhang,Xiaobin Shang,Ting Gong,Guang Ning,Jun Wang,Jun Wang,Ke Zen,Junfeng Zhang,Chen-Yu Zhang +31 more
TL;DR: It is demonstrated that miRNAs are present in the serum and plasma of humans and other animals such as mice, rats, bovine fetuses, calves, and horses, and can serve as potential biomarkers for the detection of various cancers and other diseases.
Journal ArticleDOI
MicroRNAs: new regulators of immune cell development and function.
David Baltimore,Mark Boldin,Ryan M. O'Connell,Dinesh S. Rao,Dinesh S. Rao,Konstantin Taganov +5 more
TL;DR: Much of the work which has so far only scratched the surface of this very fertile field of investigation is brought together, and the results illuminate many historic questions about hematopoiesis and immune function.
Journal ArticleDOI
Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies.
Colin C. Pritchard,Evan M. Kroh,Brent L. Wood,Jason D. Arroyo,Katy Dougherty,Melanie M. Miyaji,Jonathan F. Tait,Muneesh Tewari +7 more
TL;DR: Evidence is presented that blood cells are a major contributor to circulating miRNA and that perturbations in blood cell counts and hemolysis can alter plasma miRNA biomarker levels by up to 50-fold.
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