Epigenetics and the placenta
TLDR
Epigenetic regulation of the placenta evolves during preimplantation development and further gestation and appears to be involved in the pathogenesis of pre-eclampsia and GTD.Abstract:
results: Epigenetic regulation of the placenta evolves during preimplantation development and further gestation. Epigenetic marks, like DNA methylation, histone modifications and non-coding RNAs, affect gene expression patterns. These expression patterns, including the important parent-of-origin-dependent gene expression resulting from genomic imprinting, play a pivotal role in proper fetal and placental development. Disturbed placental epigenetics has been demonstrated in cases of intrauterine growth retardation and small for gestational age, and also appears to be involved in the pathogenesis of pre-eclampsia and GTD. Several environmental effects have been investigated so far, e.g. ethanol, oxygen tension as well as the effect of several aspects of assisted reproduction technologies on placental epigenetics. conclusions: Studies in both animals and humans have made it increasingly clear that proper epigenetic regulation of both imprinted and non-imprinted genes is important in placental development. Its disturbance, which can be caused by various environmental factors, can lead to abnormal placental development and function with possible consequences for maternal morbidity, fetal development and disease susceptibility in later life.read more
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Epigenetics in Society
Lina Chaker,Kendall Diemer,Florida Doci,Curtis Foreman,Natalie Gosselin,Jessica Hebert,Aaron Hegazi,Roni Hetzel,Marisa Market,Jake Pfaff,Kaela Scott,Candace Spencer,Nadia Timperio,Kaylyn Tobin,Clare J. Venney,Melissa Woghiren,Sandy Zakaria,Michael J Crawford +17 more
TL;DR: In the years since the human genome was sequenced, it has become apparent that this higher order of architectural organization is much more complex and subtle than formerly acknowledged.
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Hypomethylation of DNA promoter upregulates ADAMTS7 and contributes to HTR-8/SVneo and JEG-3 cells abnormalities in pre-eclampsia.
Lu Zhang,Fei Zhao,Chuan Li,Hong Li,Qian Tang,Yunqing Chen,Yushuang Yao,Zhaoxia Ding,Yinglei Xu,Aiping Chen,Shiguo Liu +10 more
TL;DR: Upregulation of ADAMTS7 by promoter hypomethylation in placenta might contribute to the etiology of PE via suppressing cell functions of trophoblasts via suppressingCell viability, migration, and invasion in vitro.
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Recurrent Pregnancy Loss (RPL): An overview
TL;DR: An insight is taken into the overall risk factors involved in the causation of explained recurrentregnancy loss to help the researchers to identify the origin of pregnancy loss and to provide best investigation and treatment strategy for women with recurrent pregnancy loss.
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Variants in Maternal Effect Genes and Relaxed Imprinting Control in a Special Placental Mesenchymal Dysplasia Case with Mild Trophoblast Hyperplasia
Tien-Chi Huang,Kung Chao Chang,Jen Yun Chang,Yi Shan Tsai,Yao Jong Yang,Wei Chun Chang,Chu Fan Mo,Pei Hsiu Yu,Chun Ting Chiang,Shau-Ping Lin,Shau-Ping Lin,Pao Lin Kuo +11 more
TL;DR: In this paper, a very special mesenchymal dysplasia (PMD) case also presenting with trophoblast hyperplasia phenotype, which is a hallmark of partial hydatidiform mole (PHM) was reported.
References
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DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
TL;DR: It is demonstrated that two recently identified DNA methyltransferases, DnMT3a and Dnmt3b, are essential for de novo methylation and for mouse development and play important roles in normal development and disease.
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TL;DR: In what case do you like reading so much? What about the type of the vitamin d the calcium homeostatic steroid hormone book? The needs to read? Well, everybody has their own reason why should read some books as discussed by the authors.
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TL;DR: Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.