Epigenetics and the placenta
TLDR
Epigenetic regulation of the placenta evolves during preimplantation development and further gestation and appears to be involved in the pathogenesis of pre-eclampsia and GTD.Abstract:
results: Epigenetic regulation of the placenta evolves during preimplantation development and further gestation. Epigenetic marks, like DNA methylation, histone modifications and non-coding RNAs, affect gene expression patterns. These expression patterns, including the important parent-of-origin-dependent gene expression resulting from genomic imprinting, play a pivotal role in proper fetal and placental development. Disturbed placental epigenetics has been demonstrated in cases of intrauterine growth retardation and small for gestational age, and also appears to be involved in the pathogenesis of pre-eclampsia and GTD. Several environmental effects have been investigated so far, e.g. ethanol, oxygen tension as well as the effect of several aspects of assisted reproduction technologies on placental epigenetics. conclusions: Studies in both animals and humans have made it increasingly clear that proper epigenetic regulation of both imprinted and non-imprinted genes is important in placental development. Its disturbance, which can be caused by various environmental factors, can lead to abnormal placental development and function with possible consequences for maternal morbidity, fetal development and disease susceptibility in later life.read more
Citations
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Nutrigenetics, epigenetics and gestational diabetes: consequences in mother and child
TL;DR: The knowledge of epigenetic modifications induced by an adverse intrauterine and perinatal environment could shed light on the potential pathophysiological mechanisms of long-term disease development in the offspring and provide useful tools for their prevention.
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Exposure to Phthalate, an Endocrine Disrupting Chemical, Alters the First Trimester Placental Methylome and Transcriptome in Women
N. M. Grindler,Lauren A. Vanderlinden,Rajendiran Karthikraj,Kurunthachalam Kannan,Stephanie B. Teal,Alex J. Polotsky,Theresa L. Powell,Ivana V. Yang,Thomas Jansson +8 more
TL;DR: These findings are consistent with the model that phthalates impact placental function by modulating the expression of critical placental genes through epigenetic regulation.
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LncRNAs Expression in Preeclampsia Placenta Reveals the Potential Role of LncRNAs Contributing to Preeclampsia Pathogenesis
Xiaoju He,Yinyan He,Binrong Xi,Jiusheng Zheng,Xiaoming Zeng,Qinhua Cai,Yu OuYang,Chen Wang,Xiaofei Zhou,Huiying Huang,Wei Deng,Siming Xin,Qixiang Huang,Huai Liu +13 more
TL;DR: This study is the first study to determine the genome-wide lncRNAs expression patterns in preeclampsia placenta using microarray and revealed that clusters of lNCRNAs were aberrantly expressed in preeClampsia Placenta compared with controls, which indicated that lnc RNAs differentially expressed in preconclampsian placentas might play a partial or key role in pree clampsia development.
Journal ArticleDOI
miRNA expression for early diagnosis of preeclampsia onset: hope or hype?
Antonio Simone Laganà,Salvatore Giovanni Vitale,Fabrizio Sapia,Gaetano Valenti,Francesco Corrado,Francesco Padula,Agnese Maria Chiara Rapisarda,Rosario D'Anna +7 more
TL;DR: In this paper, a review about miRNA expression in placenta and maternal serum levels both in uncomplicated and preeclampsia pregnancies is presented. But the role of miRNAs in PE onset is not discussed.
Journal ArticleDOI
The Role of Epigenetics in Placental Development and the Etiology of Preeclampsia
TL;DR: The potential use of epigenetic marks circulating in the maternal blood flow as putative biomarkers able to prognosticate the onset of PE are explored, as well as classifying it according to its severity.
References
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Vitamin D
TL;DR: In what case do you like reading so much? What about the type of the vitamin d the calcium homeostatic steroid hormone book? The needs to read? Well, everybody has their own reason why should read some books as discussed by the authors.
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TL;DR: Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.