Epigenetics and the placenta
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TLDR
Epigenetic regulation of the placenta evolves during preimplantation development and further gestation and appears to be involved in the pathogenesis of pre-eclampsia and GTD.Abstract:
results: Epigenetic regulation of the placenta evolves during preimplantation development and further gestation. Epigenetic marks, like DNA methylation, histone modifications and non-coding RNAs, affect gene expression patterns. These expression patterns, including the important parent-of-origin-dependent gene expression resulting from genomic imprinting, play a pivotal role in proper fetal and placental development. Disturbed placental epigenetics has been demonstrated in cases of intrauterine growth retardation and small for gestational age, and also appears to be involved in the pathogenesis of pre-eclampsia and GTD. Several environmental effects have been investigated so far, e.g. ethanol, oxygen tension as well as the effect of several aspects of assisted reproduction technologies on placental epigenetics. conclusions: Studies in both animals and humans have made it increasingly clear that proper epigenetic regulation of both imprinted and non-imprinted genes is important in placental development. Its disturbance, which can be caused by various environmental factors, can lead to abnormal placental development and function with possible consequences for maternal morbidity, fetal development and disease susceptibility in later life.read more
Citations
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Impact of Abnormal DNA Methylation of Imprinted Loci on Human Spontaneous Abortion
Yu-Dong Liu,Yan Tang,De-Sheng Ye,Wei-Xu Ma,Shu-Xian Feng,Xue-Lan Li,Xing-Yu Zhou,Xin Chen,Shi-Ling Chen +8 more
TL;DR: DNA methylation patterns of 3 imprinted genes were evaluated in human chorionic villus samples and provided support for the opinion that genetic imprinting defects may be associated with SA, which might not be due to ART treatments.
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Hyper-methylation of AVPR1A and PKCΒ gene associated with insensitivity to arginine vasopressin in human pre-eclamptic placental vasculature.
Qinqin Gao,Huan Li,Hongmei Ding,Xiaorong Fan,Ting Xu,Jiaqi Tang,Yanping Liu,Xueyi Chen,Xiuwen Zhou,Jianying Tao,Zhice Xu +10 more
TL;DR: The present study found that vasoconstriction responses of placental vessels to AVP were attenuated in pre-eclampsia as compared to in normal pregnancy, and revealed that aberrant DNA methylation-mediated gene expressions are correlated with vascular dysfunction in pre -eclamptic placental circulation.
Journal ArticleDOI
Application of Multiplex Nested Methylated Specific PCR in Early Diagnosis of Epithelial Ovarian Cancer
TL;DR: Serum free DNA methylation can be used as a biological marker for EOC and multiplex nested methylated specific PCR should be considered for early diagnosis since it can accurately determine tumor methylation conditions.
Journal ArticleDOI
The effects of assisted reproduction technologies on metabolic health and disease
TL;DR: In this paper, the authors focused on evidence of adverse metabolic alterations associated with ART, which can contribute to the development of chronic adult-onset diseases, such as metabolic syndrome, type 2 diabetes, and cardiovascular disease.
Journal ArticleDOI
Birth weight, umbilical and placental traits in relation to neonatal loss in cloned pigs.
Zheng Ao,Dewu Liu,Chengfa Zhao,Zhimin Yue,Junsong Shi,Rong Zhou,Gengyuan Cai,Enqin Zheng,Zicong Li,Zhenfang Wu +9 more
TL;DR: Results indicate that birth weight, umbilical status, placental parameters, placential morphology and gene expression were associated with neonatal death of cloned piglets.
References
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TL;DR: Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.