Formation of propionate and butyrate by the human colonic microbiota
Petra Louis,Harry J. Flint +1 more
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TLDR
This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between different gut bacteria.Abstract:
The human gut microbiota ferments dietary non-digestible carbohydrates into short-chain fatty acids (SCFA). These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting functions. Here an overview of the metabolic pathways utilized by gut microbes to produce these two SCFA from dietary carbohydrates and from amino acids resulting from protein breakdown is provided. This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between different gut bacteria. The ecophysiology, including growth requirements and responses to environmental factors, of major propionate and butyrate producing bacteria are discussed in relation to dietary modulation of these metabolites. A detailed understanding of SCFA metabolism by the gut microbiota is necessary to underpin effective strategies to optimize SCFA supply to the host.read more
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Polysorbate 80 improves the adhesion and survival of yogurt starters with cholesterol uptake abilities
Hasnia Ziar,Asma Riazi +1 more
TL;DR: In this article , the authors used polysorbate 80, a food additive emulsifier commonly found in milk derivative products, to improve the adhesion and survival of yogurt bacteria with probiotic traits.
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Impact of Geographical Location on the Gut Microbiota Profile in Egyptian Children with Type 1 Diabetes Mellitus: A Pilot Study
Nahla M. Elsherbiny,Mohammed A. Ramadan,Nagla H. Abu Faddan,Elham A. Hassan,Mohamed E. Ali,Abeer Sharaf El-Din Abd El-Rehim,Wael A. Abbas,Mohamed A A Abozaid,Ebtisam Hassanin,Ghada A. Mohamed,Helal F Hetta,Mohammed Salah +11 more
TL;DR: There are a number of consistent changes in the microbiota profile characterizing the diabetic groups irrespective of the geographical location including significantly lower alpha diversity, mean Firmicutes/ Bacteroidetes (F/B) ratio, and reduced proportions of Firmicute and genera Prevotella and Ruminococcus.
Journal ArticleDOI
The Role of the Gut Microbiota in the Effects of Early-Life Stress and Dietary Fatty Acids on Later-Life Central and Metabolic Outcomes in Mice
TL;DR: In this article , the impact of early-life stress and dietary PUFAs on the Gut Microbiota was investigated and the results showed that a low dietary ω-6/ω-3 PUFA ratio protects against ELS-induced cognitive impairments.
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Composition and functional profiles of human faecal microbiota fermenting plant-based food particles are related to water-holding capacity more than particle size
TL;DR: In this paper , two different particle sizes for sorghum, wheat grain, oat bran, apple, and carrot were fermented in vitro and DNA was extracted and underwent 16S gene sequencing, followed by the profiling of microbial composition and predicted functions.
References
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From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
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Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Douglas J. Morrison,Tom Preston +1 more
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The gut microbiota, bacterial metabolites and colorectal cancer
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