Formation of propionate and butyrate by the human colonic microbiota
Petra Louis,Harry J. Flint +1 more
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TLDR
This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between different gut bacteria.Abstract:
The human gut microbiota ferments dietary non-digestible carbohydrates into short-chain fatty acids (SCFA). These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting functions. Here an overview of the metabolic pathways utilized by gut microbes to produce these two SCFA from dietary carbohydrates and from amino acids resulting from protein breakdown is provided. This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between different gut bacteria. The ecophysiology, including growth requirements and responses to environmental factors, of major propionate and butyrate producing bacteria are discussed in relation to dietary modulation of these metabolites. A detailed understanding of SCFA metabolism by the gut microbiota is necessary to underpin effective strategies to optimize SCFA supply to the host.read more
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Next-generation probiotics – do they open new therapeutic strategies for cancer patients?
Karolina Kaźmierczak-Siedlecka,Karolina Skonieczna-Żydecka,T. Hupp,Renata Duchnowska,Natalia Marek-Trzonkowska,Karol Polom +5 more
TL;DR: Emerging studies indicate a beneficial role of these NGPs in the prevention of carcinogenesis and open new promising therapeutic options for cancer patients.
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Differences in Fecal Gut Microbiota, Short-Chain Fatty Acids and Bile Acids Link Colorectal Cancer Risk to Dietary Changes Associated with Urbanization Among Zimbabweans.
Leolin Katsidzira,Soeren Ocvirk,Annette Wilson,Jia V. Li,C. B. Mahachi,D. Soni,James P. DeLany,Jeremy K. Nicholson,Erwin G. Zoetendal,Stephen J. O'Keefe +9 more
TL;DR: The gut microbiota composition and activity among rural and urban Zimbabweans retain significant homogeneity, but urban residents have subtle changes, which may indicate a higher CRC risk.
Journal ArticleDOI
Microbial lactate utilisation and the stability of the gut microbiome
TL;DR: The potential consequences of perturbation of the microbiota leading to lactate accumulation in the gut and associated disease states and how lactate-utilising bacteria may be employed to treat such diseases are discussed.
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Correlation Analysis between GDM and Gut Microbial Composition in Late Pregnancy.
Genxia Li,Pan Yin,Shuhui Chu,Wanli Gao,Shihong Cui,Shuhua Guo,Yajuan Xu,Enwu Yuan,Texuan Zhu,Jie You,Junya Zhang,Manman Yang +11 more
TL;DR: In this article, the authors explored the characteristics of the intestinal flora of patients with gestational diabetes in the third trimester of pregnancy and found the intestinal microbiota with significant differences in healthy pregnant women to provide a basis for future clinical attempts of using intestinal microecological agents to treat GDM.
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Bacteria in the ageing gut: did the taming of fire promote a long human lifespan?
TL;DR: It is proposed here that positive selection of metabolic functions allowed the body of hominins who tamed fire to use and dispose of these age-related compounds, which resulted in extending human lifespan far beyond that of the authors' great ape cousins.
References
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A human gut microbial gene catalogue established by metagenomic sequencing
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Journal ArticleDOI
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
TL;DR: Data is reviewed supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs), which affect various physiological processes and may contribute to health and disease.
Journal ArticleDOI
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Douglas J. Morrison,Tom Preston +1 more
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The gut microbiota, bacterial metabolites and colorectal cancer
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