Geographic Patterns of Genome Admixture in Latin American Mestizos
Sijia Wang,Nicolas Ray,Winston Rojas,María Victoria Parra,Gabriel Bedoya,Carla Gallo,Giovanni Poletti,Guido Mazzotti,Kim Hill,A. M. Hurtado,Beatriz Camrena,Humberto Nicolini,William Klitz,Ramiro Barrantes,Julio Molina,Nelson B. Freimer,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,José E. Dipierri,Emma L. Alfaro,Graciela Bailliet,Néstor O. Bianchi,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Andres Ruiz-Linares +28 more
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TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.Abstract:
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.read more
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Ancestry Informative Markers Clarify the Regional Admixture Variation in the Costa Rican Population
TL;DR: Though the authors did not find stratification in Costa Rica's population, gene admixture should be evaluated in future genetic studies of Costa Rica, especially for the Caribbean region, as it contains the largest proportion of African ancestry (30.9%).
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Weighted likelihood inference of genomic autozygosity patterns in dense genotype data
TL;DR: This weighted likelihood ROA inference approach can assist population- and disease-geneticists working with a wide variety of data types and species to explore ROA patterns and to identify genomic regions with differential ROA signals among groups, thereby advancing the understanding of evolutionary history and the role of recessive variation in phenotypic variation and disease.
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Association of Lactase Persistence Genotypes with High Intake of Dairy Saturated Fat and High Prevalence of Lactase Non-Persistence among the Mexican Population.
Claudia Ojeda-Granados,Arturo Panduro,João Renato Rebello Pinho,Omar Ramos-Lopez,Ketti Gleyzer,Fernanda de Mello Malta,Karina Gonzalez-Aldaco,Sonia Roman +7 more
TL;DR: The LNP trait was predominant in Mexicans with a major Amerindian ancestry and a daily consumption of dairy was associated with a higher intake of saturated fat in LP individuals.
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Multiple Sclerosis in Latin Americans: Genetic Aspects.
TL;DR: Genome-Wide Association Studies in LA show diverse variants and genetic proportions among Mestizos, the most representative ethnic population, who themselves are the product of centuries of interracial mixing between Native Americans (or Amerindians), White Caucasian Europeans, and Black Africans.
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Genetic admixture estimates by Alu elements in Afro-Colombian and Mestizo populations from Antioquia, Colombia.
Luis Gómez-Pérez,Miguel A. Alfonso-Sánchez,A.M. Pérez-Miranda,Susana García-Obregón,Juan José Builes,María Luisa Bravo,Marian M. de Pancorbo,José A. Peña +7 more
TL;DR: The peculiarity of the Afro-Colombian gene pool seems to be associated with intense genetic drift episodes that occurred in isolated communities founded by small groups of runaway slaves.
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