Geographic Patterns of Genome Admixture in Latin American Mestizos
Sijia Wang,Nicolas Ray,Winston Rojas,María Victoria Parra,Gabriel Bedoya,Carla Gallo,Giovanni Poletti,Guido Mazzotti,Kim Hill,A. M. Hurtado,Beatriz Camrena,Humberto Nicolini,William Klitz,Ramiro Barrantes,Julio Molina,Nelson B. Freimer,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,José E. Dipierri,Emma L. Alfaro,Graciela Bailliet,Néstor O. Bianchi,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Andres Ruiz-Linares +28 more
Reads0
Chats0
TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.Abstract:
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.read more
Citations
More filters
Journal ArticleDOI
Reconstructing Native American population history
David Reich,David Reich,Nick Patterson,Desmond Campbell,Desmond Campbell,Arti Tandon,Arti Tandon,Stéphane Mazières,Stéphane Mazières,Nicolas Ray,María Victoria Parra,María Victoria Parra,Winston Rojas,Winston Rojas,Constanza Duque,Constanza Duque,Natalia Mesa,Natalia Mesa,Luis F. García,Omar Triana,Silvia Blair,Amanda Maestre,Juan Carlos Dib,Claudio M. Bravi,Claudio M. Bravi,Graciela Bailliet,Daniel Corach,Tábita Hünemeier,Tábita Hünemeier,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Victor Acuña-Alonzo,Carlos A. Aguilar-Salinas,Samuel Canizales-Quinteros,Teresa Tusié-Luna,Laura Riba,Maricela Rodríguez-Cruz,Mardia López-Alarcón,Ramón Mauricio Coral-Vázquez,Thelma Canto-Cetina,Irma Silva-Zolezzi,Juan Carlos Fernández-López,Alejandra V. Contreras,Gerardo Jimenez-Sanchez,María José Gómez-Vázquez,Julio Molina,Angel Carracedo,Antonio Salas,Carla Gallo,Giovanni Poletti,David B. Witonsky,Gorka Alkorta-Aranburu,Rem I. Sukernik,Ludmila P. Osipova,Sardana A. Fedorova,René Vasquez,Mercedes Villena,Claudia Moreau,Ramiro Barrantes,David L. Pauls,Laurent Excoffier,Laurent Excoffier,Gabriel Bedoya,Francisco Rothhammer,Jean-Michel Dugoujon,Georges Larrouy,William Klitz,Damian Labuda,Judith R. Kidd,Kenneth K. Kidd,Anna Di Rienzo,Nelson B. Freimer,Alkes L. Price,Alkes L. Price,Andres Ruiz-Linares +75 more
TL;DR: It is shown that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America.
Journal ArticleDOI
Genome-wide association studies in diverse populations
Noah A. Rosenberg,Lucy Huang,Ethan M. Jewett,Zachary A. Szpiech,Ivana Jankovic,Michael Boehnke +5 more
TL;DR: Investigation of a greater diversity of populations could make substantial contributions to the goal of mapping the genetic determinants of complex diseases for the human population as a whole.
Journal ArticleDOI
The Genetic Ancestry of African Americans, Latinos, and European Americans across the United States
Katarzyna Bryc,Eric Durand,J. Michael Macpherson,David Reich,David Reich,David Reich,Joanna L. Mountain +6 more
TL;DR: The authors studied the genetic ancestry of 5,269 self-described African Americans, 8,663 Latinos, and 148,789 European Americans who are 23andMe customers and showed that the legacy of these historical interactions is visible in the genetic lineage of present-day Americans.
Journal ArticleDOI
Planning cancer control in Latin America and the Caribbean
Paul E. Goss,Brittany L. Lee,Brittany L. Lee,Tanja Badovinac-Crnjevic,Kathrin Strasser-Weippl,Yanin Chavarri-Guerra,Jessica St. Louis,Cynthia Villarreal-Garza,Karla Unger-Saldaña,Mayra Ferreyra,Marcio Debiasi,Pedro E.R. Liedke,Diego Touya,Gustavo Werutsky,Michaela J. Higgins,Lei Fan,Claudia Vasconcelos,Eduardo Cazap,Carlos S. Vallejos,Alejandro Mohar,Felicia Marie Knaul,Héctor Arreola,Rekha Batura,Silvana Luciani,Richard Sullivan,Dianne M. Finkelstein,Sergio Daniel Simon,Carlos H. Barrios,Rebecca S. Kightlinger,Andres Gelrud,Vladimir Bychkovsky,Gilberto Lopes,Gilberto Lopes,Stephen Stefani,Marcelo Blaya,Fabiano Hahn Souza,Franklin Santana Santos,Alberto Kaemmerer,Evandro de Azambuja,Andres Felipe Cardona Zorilla,Raúl Murillo,Jose Jeronimo,Vivien Tsu,André Lopes Carvalho,Carlos Ferreira Gil,Cinthya Sternberg,Alfonso Dueñas-González,Dennis C. Sgroi,Mauricio Cuello,Rodrigo Fresco,Rui Manuel Reis,G. Masera,Raul Gabus,Raul C. Ribeiro,Raul C. Ribeiro,Renata Knust,Gustavo Ismael,Eduardo Rosenblatt,B. M. C. Roth,Luisa L. Villa,Argelia Lara Solares,Marta Ximena Leon,Isabel Torres-Vigil,Isabel Torres-Vigil,Alfredo Covarrubias-Gómez,Andrés Hernández,Mariela Bertolino,Gilberto Schwartsmann,Sergio Santillana,Francisco J. Esteva,Luis Fein,Max S. Mano,Henry L. Gomez,Marc Hurlbert,Alessandra Durstine,Gustavo S. Azenha +75 more
TL;DR: In this article, the authors present the findings of their Cancer Commission and their recommendations to encourage Latin American stakeholders to redouble their efforts to address this increasing cancer burden and to prevent it from worsening and threatening their societies.
Journal ArticleDOI
The genetics of Mexico recapitulates Native American substructure and affects biomedical traits
Andrés Moreno-Estrada,Christopher R. Gignoux,Juan Carlos Fernández-López,Fouad Zakharia,Martin Sikora,Alejandra V. Contreras,Victor Acuña-Alonzo,Karla Sandoval,Celeste Eng,Sandra Romero-Hidalgo,Patricia Ortiz-Tello,Victoria Robles,Eimear E. Kenny,Ismael Nuño-Arana,Rodrigo Barquera-Lozano,Gastón Macín-Pérez,Julio Granados-Arriola,Scott Huntsman,Joshua Galanter,Marc Via,Jean G. Ford,Rocio Chapela,William Rodriguez-Cintron,J.R. Rodriguez-Santana,Isabelle Romieu,Juan José Luis Sienra-Monge,Blanca E. del Rio Navarro,Stephanie J. London,Andres Ruiz-Linares,Rodrigo García-Herrera,Karol Estrada,Alfredo Hidalgo-Miranda,Gerardo Jimenez-Sanchez,Alessandra Carnevale,Xavier Soberón,Samuel Canizales-Quinteros,Héctor Rangel-Villalobos,Irma Silva-Zolezzi,Esteban G. Burchard,Carlos Bustamante +39 more
TL;DR: Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country, and two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function.
References
More filters
Journal ArticleDOI
A Genomewide Admixture Mapping Panel for Hispanic/Latino Populations
Xianyun Mao,Abigail W. Bigham,Rui Mei,Gerardo Gutiérrez,Kenneth M. Weiss,Tom D. Brutsaert,Fabiola León-Velarde,Lorna G. Moore,Enrique Vargas,Paul M. McKeigue,Mark D. Shriver,Esteban J. Parra +11 more
TL;DR: This report reports a genomewide AM panel with 2,120 AIMs showing high frequency differences between Native American and European populations, which will make it possible to apply AM approaches in many admixed populations throughout the Americas.
Journal Article
Admixture studies in Latin America: from the 20th to the 21st century.
TL;DR: From these studies it is possible to conclude that Amerindian admixture came mainly from female lineages, but it is difficult to establish what happened with the African contribution.
Journal ArticleDOI
Mapping by admixture linkage disequilibrium: advances, limitations and guidelines.
TL;DR: Under ideal circumstances, MALD will have more power to detect some genetic variants than other types of genome-wide association study that are carried out among more ethnically homogeneous populations, and it will also require 200–500 times fewer markers, providing a significant economic advantage.
Journal ArticleDOI
Prospects for admixture mapping of complex traits.
TL;DR: Statistical-analysis programs for admixture mapping are now available, and a genomewide panel of markers for admixtures mapping in populations formed by West African-European admixture has been assembled.
Book
The Evolution and Genetics of Latin American Populations
TL;DR: In this paper, the authors examined for the first time Latin American human populations in relation to their origins, environment, history, demography and genetics, drawing on aspects of nutrition, physiology and morphology for an integrated and multidisciplinary approach.
Related Papers (5)
Genetic Variation and Population Structure in Native Americans
Sijia Wang,Cecil M. Lewis,Mattias Jakobsson,Sohini Ramachandran,Nicolas Ray,Gabriel Bedoya,Winston Rojas,María Victoria Parra,Julio Molina,Carla Gallo,Guido Mazzotti,Giovanni Poletti,Kim Hill,A. M. Hurtado,Damian Labuda,William Klitz,Ramiro Barrantes,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Marcus W. Feldman,Noah A. Rosenberg,Andres Ruiz-Linares +27 more