Geographic Patterns of Genome Admixture in Latin American Mestizos
Sijia Wang,Nicolas Ray,Winston Rojas,María Victoria Parra,Gabriel Bedoya,Carla Gallo,Giovanni Poletti,Guido Mazzotti,Kim Hill,A. M. Hurtado,Beatriz Camrena,Humberto Nicolini,William Klitz,Ramiro Barrantes,Julio Molina,Nelson B. Freimer,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,José E. Dipierri,Emma L. Alfaro,Graciela Bailliet,Néstor O. Bianchi,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Andres Ruiz-Linares +28 more
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TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.Abstract:
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.read more
Citations
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Paleogenetical study of pre-Columbian samples from Pampa Grande (Salta, Argentina).
Fransisco R. Carnese,Fanny Mendisco,Fanny Mendisco,Christine Keyser,Cristina B. Dejean,Jean-Michel Dugoujon,Claudio M. Bravi,Bertrand Ludes,Eric Crubézy +8 more
TL;DR: The described genetic diversity indicates homogeneity in the genetic structure of the ancient Andean populations, which was probably facilitated by the intense exchange network in the Andean zone, in particular among Tiwanaku, San Pedro de Atacama, and NWA.
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Whole Genome Sequence and Phylogenetic Analysis Show Helicobacter pylori Strains from Latin America Have Followed a Unique Evolution Pathway.
Zilia Y. Muñoz-ramirez,Alfonso Méndez-Tenorio,Ikuko Kato,María Mercedes Bravo,Cosmeri Rizzato,Kaisa Thorell,Roberto Gamón Torres,Francisco Avilés-Jiménez,Margarita Camorlinga,Federico Canzian,Javier Torres +10 more
TL;DR: Results suggests that in the new world, H. pylori has evolved to fit mestizo LA populations, already 500 years after the Spanish colonization, which may account for regional variability in gastric cancer risk.
Journal ArticleDOI
Admixture and genetic relationships of Mexican Mestizos regarding Latin American and Caribbean populations based on 13 CODIS-STRs
Joel Salazar-Flores,F. Zuñiga-Chiquette,Rodrigo Rubi-Castellanos,J.L. Álvarez-Miranda,A. Zetina-Hérnandez,V.M. Martínez-Sevilla,Fabricio González-Andrade,Daniel Corach,Carlos Vullo,Juan Carlos Alvarez,José A. Lorente,Paula Sánchez-Diz,Rene J. Herrera,Ricardo M. Cerda-Flores,J.F. Muñoz-Valle,Héctor Rangel-Villalobos +15 more
TL;DR: CODIS-STRs allowed detecting significant population structure in Latin America based on greater presence of European, Amerindian, and African ancestries in Central/South America, Mexican Mestizos, and the Caribbean, respectively.
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BRCA1 And BRCA2 analysis of Argentinean breast/ovarian cancer patients selected for age and family history highlights a role for novel mutations of putative south-American origin
Angela R. Solano,Gitana Aceto,Dreanina Delettieres,Serena Veschi,Maria Isabel Neuman,Eduardo Alonso,Sergio Chialina,Reinaldo Chacón,Mariani-Costantini Renato,Ernesto J. Podestá +9 more
TL;DR: This study, the first conducted in Argentinean patients, highlights a significant impact of novel BRCA1/2 mutations and genetic variants, which may be regarded as putatively South American, and confirms the important role of founder BRC a1 and BRCa2 mutations in Argentineaan Ashkenazi Jews.
Journal ArticleDOI
Ancestry informative markers and admixture proportions in northeastern Mexico
Margarita L Martinez-Fierro,Joke Beuten,Robin J. Leach,Esteban J. Parra,Miguel Cruz-López,Héctor Rangel-Villalobos,Lina Riego-Ruiz,Rocio Ortiz-Lopez,Herminia G. Martínez-Rodríguez,Augusto Rojas-Martinez +9 more
TL;DR: The paternal lineage calculated by genotyping of 15 Y-SNPs, shows a major component of European and Eurasian ancestry markers (∼78%), compared with Amerindian and African markers (10%).
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