Geographic Patterns of Genome Admixture in Latin American Mestizos
Sijia Wang,Nicolas Ray,Winston Rojas,María Victoria Parra,Gabriel Bedoya,Carla Gallo,Giovanni Poletti,Guido Mazzotti,Kim Hill,A. M. Hurtado,Beatriz Camrena,Humberto Nicolini,William Klitz,Ramiro Barrantes,Julio Molina,Nelson B. Freimer,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,José E. Dipierri,Emma L. Alfaro,Graciela Bailliet,Néstor O. Bianchi,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Andres Ruiz-Linares +28 more
Reads0
Chats0
TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.Abstract:
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.read more
Citations
More filters
Journal ArticleDOI
Differential admixture, human leukocyte antigen diversity, and hematopoietic cell transplantation in Latin America: challenges and opportunities
TL;DR: How the differential admixture processes that took and continue to take place in Latin America impact the diversity of HLA in the region are illustrated and why this is a crucial factor to consider for the expansion of HCT are proposed.
Journal ArticleDOI
Subscapular and triceps skinfolds reference values of hispanic american children and adolescents and their comparison with the reference of centers for disease control and prevention (cdc).
María Dolores Marrodán Serrano,Marisa González Montero de Espinosa,Angel Herráez,Emma L. Alfaro,Ignacio Bejarano,María M. Carmenate,Consuelo Prado,Delia Beatriz Lomaglio,Noemí López-Ejeda,Antonio J. Martínez,María Soledad Mesa,Betty M Pérez,Juana María Meléndez,Susana Moreno Romero,José L. Pacheco,Vanessa Vázquez,José E. Dipierri +16 more
TL;DR: Skinfolds measurements obviously increased with age in both sexes but, in boys, this increase is much more marked in highest percentiles between 8 and 13 years; this maximum is reached earlier than what occurs in CDC reference.
Construyendo una dieta correcta con base en el genoma latino
TL;DR: In this review, a proposal for nutritional intervention for people in the Latin-American region, included Mexico is presented, an initial strategy that considers the overall genomic and environmental features of the population and subgroups for the prevention and management of chronic diseases.
Journal ArticleDOI
Characterisation of genetic structure of the Mayan population in Guatemala by autosomal STR analysis.
Luis Javier Martinez-Gonzalez,Maria Jesus Alvarez-Cubero,María Saiz,Juan Carlos Alvarez,Cristina Martínez-Labarga,José A. Lorente +5 more
TL;DR: This study represents one of the first steps in understanding Mayan–Guatemalan populations, the associations between their sub-populations and differences in gene diversity with other populations.
Journal ArticleDOI
Association between the APOE ε4 Allele and Late-Onset Alzheimer's Disease in an Ecuadorian Mestizo Population.
Stefany Montufar,Cristian Calero,Rodrigo Vinueza,Patricio Correa,Andrea Carrera-Gonzalez,Franklin Villegas,Germania Moreta,Rosario Paredes +7 more
TL;DR: It is concluded that APOE ε4 must be considered an important genetic risk factor for LOAD in the Ecuadorian Mestizo population and suggested that in mixed populations the effects of admixture and ethnic identity should be differentiated when evaluating genetic contributions to Alzheimer's disease risk.
References
More filters
Journal ArticleDOI
Inference of population structure using multilocus genotype data
TL;DR: Pritch et al. as discussed by the authors proposed a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations, which can be applied to most of the commonly used genetic markers, provided that they are not closely linked.
Journal ArticleDOI
Inference of Population Structure Using Multilocus Genotype Data: Linked Loci and Correlated Allele Frequencies
TL;DR: Extensions to the method of Pritchard et al. for inferring population structure from multilocus genotype data are described and methods that allow for linkage between loci are developed, which allows identification of subtle population subdivisions that were not detectable using the existing method.
Journal ArticleDOI
A Human Genome Diversity Cell Line Panel
Howard M. Cann,Claudia de Toma,Lucien Cazes,Marie Fernande Legrand,Valérie Morel,Laurence Piouffre,J. G. Bodmer,Walter F. Bodmer,Batsheva Bonne-Tamir,Anne Cambon-Thomsen,Zhu Chen,Jiayou Chu,Carlo Carcassi,Licinio Contu,Ruofu Du,Laurent Excoffier,G. B. Ferrara,Jonathan S. Friedlaender,Helena Groot,David Gurwitz,Trefor Jenkins,Rene J. Herrera,Xiaoyi Huang,Judith R. Kidd,Kenneth K. Kidd,André Langaney,Alice A. Lin,S. Qasim Mehdi,Peter Parham,Alberto Piazza,Maria Pia Pistillo,Yaping Qian,Qunfang Shu,Jiujin Xu,Shi-Yao Zhu,James L. Weber,Henry T. Greely,Marcus W. Feldman,Gilles Thomas,Jean Dausset,Luigi Luca Cavalli-Sforza +40 more
TL;DR: A resource of 1064 cultured lymphoblastoid cell lines from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation Jean Dausset (CEPH) in Paris.
Journal ArticleDOI
Estimating African American admixture proportions by use of population-specific alleles.
Esteban J. Parra,Amy Marcini,Joshua M. Akey,Jeremy J. Martinson,Mark A. Batzer,Richard S. Cooper,Terrence Forrester,David B. Allison,Ranjan Deka,Robert E. Ferrell,Mark D. Shriver +10 more
TL;DR: Significant nonrandom association between two markers located 22 cM apart (FY-null and AT3) is detected, most likely due to admixture linkage disequilibrium created in the interbreeding of the two parental populations, emphasize the importance of admixed populations as a useful resource for mapping traits with different prevalence in two parental population.
Related Papers (5)
Genetic Variation and Population Structure in Native Americans
Sijia Wang,Cecil M. Lewis,Mattias Jakobsson,Sohini Ramachandran,Nicolas Ray,Gabriel Bedoya,Winston Rojas,María Victoria Parra,Julio Molina,Carla Gallo,Guido Mazzotti,Giovanni Poletti,Kim Hill,A. M. Hurtado,Damian Labuda,William Klitz,Ramiro Barrantes,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Marcus W. Feldman,Noah A. Rosenberg,Andres Ruiz-Linares +27 more