Geographic Patterns of Genome Admixture in Latin American Mestizos
Sijia Wang,Nicolas Ray,Winston Rojas,María Victoria Parra,Gabriel Bedoya,Carla Gallo,Giovanni Poletti,Guido Mazzotti,Kim Hill,A. M. Hurtado,Beatriz Camrena,Humberto Nicolini,William Klitz,Ramiro Barrantes,Julio Molina,Nelson B. Freimer,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,José E. Dipierri,Emma L. Alfaro,Graciela Bailliet,Néstor O. Bianchi,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Andres Ruiz-Linares +28 more
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TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.Abstract:
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.read more
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Amerind Ancestry, Socioeconomic Status and the Genetics of Type 2 Diabetes in a Colombian Population
Desmond Campbell,María Victoria Parra,María Victoria Parra,Constanza Duque,Constanza Duque,Natalia Gallego,Liliana Franco,Arti Tandon,Tábita Hünemeier,Cátira Bortolini,Alberto Villegas,Gabriel Bedoya,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Alkes L. Price,David Reich,David Reich,Andres Ruiz-Linares +18 more
TL;DR: The “thrifty genotype” hypothesis proposes that the high prevalence of type 2 diabetes in Native Americans and admixed Latin Americans has a genetic basis and reflects an evolutionary adaptation to a past low calorie/high exercise lifestyle, but identification of the gene variants underpinning this hypothesis remains elusive.
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Shared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis
Paola Cruz-Tapias,Oscar-Mauricio Perez-Fernandez,Adriana Rojas-Villarraga,Alberto Rodriguez-Rodriguez,Maria-Teresa Arango,Juan-Manuel Anaya +5 more
TL;DR: Results indicate that in Latin Americans ADs share major loci and immune characteristics, and opposite associations were found between multiple sclerosis (MS) and T1D.
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Analysis of Population Substructure in Two Sympatric Populations of Gran Chaco, Argentina
Federica Sevini,Daniele Yang Yao,Laura Lomartire,Annalaura Barbieri,Dario Vianello,Gianmarco Ferri,Edgardo Moretti,Maria Cristina Dasso,Paolo Garagnani,Davide Pettener,Claudio Franceschi,Donata Luiselli,Zelda Alice Franceschi +12 more
TL;DR: By reconstructing the genetic background and the structure of these two culturally different populations, the pattern of admixture, the correspondence between genealogical and genetic relationships, this integrated perspective had the power to validate data and to link the gap usually relying on a singular discipline.
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Admixed ancestry and stratification of Quebec regional populations.
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Maternal admixture and population structure in Mexican-mestizos based on mtDNA haplogroups
Gabriela Martínez-Cortés,Joel Salazar-Flores,Javier Haro-Guerrero,Rodrigo Rubi-Castellanos,Jesús Salvador Velarde-Félix,José Francisco Muñoz-Valle,Mavil López-Casamichana,Eduardo Carrillo-Tapia,Luis Miguel Canseco-Ávila,Claudio M. Bravi,Mauro López-Armenta,Héctor Rangel-Villalobos +11 more
TL;DR: The comparison of paternal and maternal lineages provided additional information concerning the gender bias admixture, mating patterns, and population structure in Mestizos throughout the Mexican territory.
References
More filters
Journal ArticleDOI
Inference of population structure using multilocus genotype data
TL;DR: Pritch et al. as discussed by the authors proposed a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations, which can be applied to most of the commonly used genetic markers, provided that they are not closely linked.
Journal ArticleDOI
Inference of Population Structure Using Multilocus Genotype Data: Linked Loci and Correlated Allele Frequencies
TL;DR: Extensions to the method of Pritchard et al. for inferring population structure from multilocus genotype data are described and methods that allow for linkage between loci are developed, which allows identification of subtle population subdivisions that were not detectable using the existing method.
Journal ArticleDOI
A Human Genome Diversity Cell Line Panel
Howard M. Cann,Claudia de Toma,Lucien Cazes,Marie Fernande Legrand,Valérie Morel,Laurence Piouffre,J. G. Bodmer,Walter F. Bodmer,Batsheva Bonne-Tamir,Anne Cambon-Thomsen,Zhu Chen,Jiayou Chu,Carlo Carcassi,Licinio Contu,Ruofu Du,Laurent Excoffier,G. B. Ferrara,Jonathan S. Friedlaender,Helena Groot,David Gurwitz,Trefor Jenkins,Rene J. Herrera,Xiaoyi Huang,Judith R. Kidd,Kenneth K. Kidd,André Langaney,Alice A. Lin,S. Qasim Mehdi,Peter Parham,Alberto Piazza,Maria Pia Pistillo,Yaping Qian,Qunfang Shu,Jiujin Xu,Shi-Yao Zhu,James L. Weber,Henry T. Greely,Marcus W. Feldman,Gilles Thomas,Jean Dausset,Luigi Luca Cavalli-Sforza +40 more
TL;DR: A resource of 1064 cultured lymphoblastoid cell lines from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation Jean Dausset (CEPH) in Paris.
Journal ArticleDOI
Estimating African American admixture proportions by use of population-specific alleles.
Esteban J. Parra,Amy Marcini,Joshua M. Akey,Jeremy J. Martinson,Mark A. Batzer,Richard S. Cooper,Terrence Forrester,David B. Allison,Ranjan Deka,Robert E. Ferrell,Mark D. Shriver +10 more
TL;DR: Significant nonrandom association between two markers located 22 cM apart (FY-null and AT3) is detected, most likely due to admixture linkage disequilibrium created in the interbreeding of the two parental populations, emphasize the importance of admixed populations as a useful resource for mapping traits with different prevalence in two parental population.
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