Geographic Patterns of Genome Admixture in Latin American Mestizos
Sijia Wang,Nicolas Ray,Winston Rojas,María Victoria Parra,Gabriel Bedoya,Carla Gallo,Giovanni Poletti,Guido Mazzotti,Kim Hill,A. M. Hurtado,Beatriz Camrena,Humberto Nicolini,William Klitz,Ramiro Barrantes,Julio Molina,Nelson B. Freimer,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,José E. Dipierri,Emma L. Alfaro,Graciela Bailliet,Néstor O. Bianchi,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Andres Ruiz-Linares +28 more
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TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.Abstract:
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.read more
Citations
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Genome‐Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture
Marta E. Alarcón-Riquelme,Julie T. Ziegler,Julio E. Molineros,Timothy D. Howard,Andrés Moreno-Estrada,Elena Sánchez-Rodríguez,Hannah C. Ainsworth,Patricia Ortiz-Tello,Mary E. Comeau,Astrid Rasmussen,Jennifer A. Kelly,Adam Adler,Eduardo M. Acevedo-Vázquez,Jorge M. Cucho-Venegas,Ignacio García-De La Torre,Mario H. Cardiel,Pedro Miranda,Luis J. Catoggio,Marco A. Maradiaga-Ceceña,Patrick M. Gaffney,Timothy J. Vyse,Lindsey A. Criswell,Betty P. Tsao,Kathy L. Sivils,Sang Cheol Bae,Judith A. James,Robert P. Kimberly,Kenneth M. Kaufman,John B. Harley,Jorge A. Esquivel-Valerio,José Francisco Moctezuma,Mercedes A. García,Guillermo A. Berbotto,Alejandra Babini,Hugo R. Scherbarth,Sergio Toloza,Vicente Baca,Swapan K. Nath,Carlos Aguilar Salinas,Lorena Orozco,Teresa Tusié-Luna,Raphael Zidovetzki,Bernardo A. Pons-Estel,Carl D. Langefeld,Chaim O. Jacob +44 more
TL;DR: In this paper, the first genome-wide association study on individuals from the Americas who are enriched for Native American heritage was performed, and the results demonstrate that studying admixed populations provides new insights in the delineation of the genetic architecture that underlies autoimmune and complex diseases.
Journal ArticleDOI
Heterogeneity in Genetic Admixture across Different Regions of Argentina
Sergio Alejandro Avena,Marc Via,Marc Via,Elad Ziv,Eliseo J. Pérez-Stable,Christopher R. Gignoux,Cristina B. Dejean,Scott Huntsman,Gabriela Torres-Mejía,Julie Dutil,Jaime Matta,Kenneth B. Beckman,Esteban G. Burchard,María Laura Parolin,Alicia S. Goicoechea,Noemí Acreche,Mariel Boquet,Maríal Del Carmen Ríos Part,Vanesa M. Fernández,Jorge Rey,Mariana C. Stern,Raúl Francisco Carnese,Laura Fejerman +22 more
TL;DR: The results demonstrate the range of variation in genetic ancestry among Argentine individuals from different regions in the country, highlighting the importance of taking this variation into account in genetic association and admixture mapping studies in this population.
Genetic make up and structure of Colombian populations by means of uniparental and biparental DNA markers (vol 143, pg 13, 2010)
Winston Rojas,María Victoria Parra,Omer Campo,María Antonieta Caro,Juan Lopera,Williams Arias,Constanza Duque,A Naranjo,J. Garcia,Candelaria Vergara,Jaime Lopera,E. Hernández,A. Valencia,Y. Caicedo,Maria Mercedes Torres,H. Groot De Restrepo,M. Cuartas,Javier Gutiérrez,Sergio Lopez,Andres Ruiz-Linares,G. Bedoya +20 more
TL;DR: Assessment of ancestry in over 1,700 individuals from 24 Colombian populations using biparental (autosomal and X-Chromosome), maternal (mtDNA), and paternal (Y-chromosome) markers indicates a pattern across regions indicative of admixture involving predominantly Native American women and European and African men.
Journal ArticleDOI
Genetic ancestry influences asthma susceptibility and lung function among Latinos
Maria Pino-Yanes,Neeta Thakur,Christopher R. Gignoux,Joshua Galanter,Lindsey A. Roth,Celeste Eng,Katherine K. Nishimura,Sam S. Oh,Hita Vora,Scott Huntsman,Elizabeth A. Nguyen,Donglei Hu,Katherine A. Drake,David V. Conti,Andrés Moreno-Estrada,Karla Sandoval,Cheryl A. Winkler,Luisa N. Borrell,Fred Lurmann,Talat Islam,Adam Davis,Harold J. Farber,Kelley Meade,Pedro C. Avila,Denise Serebrisky,Kirsten Bibbins-Domingo,Michael A. LeNoir,Jean G. Ford,Emerita Brigino-Buenaventura,William Rodriguez-Cintron,Shannon Thyne,Saunak Sen,Jose R. Rodriguez-Santana,Carlos Bustamante,L. Keoki Williams,Frank D. Gilliland,W. James Gauderman,Rajesh Kumar,Dara G. Torgerson,Esteban G. Burchard +39 more
TL;DR: For example, the authors found that Native American ancestry was associated with lower odds of asthma (OR = 0.72, 95% CI: 0.66-0.78, P ǫ= 8.0 × 10 −15 ), while African ancestry was significantly associated with higher odds of having asthma.
Journal ArticleDOI
Folic acid flour fortification: Impact on the frequencies of 52 congenital anomaly types in three South American countries
TL;DR: It is concluded that food fortification with folic acid prevents NTDs but not other types of congenital anomalies, and suggests etiologic and pathogenetic heterogeneity among different levels of spina bifida, as well as among different NTD subtypes.
References
More filters
Journal ArticleDOI
Inference of population structure using multilocus genotype data
TL;DR: Pritch et al. as discussed by the authors proposed a model-based clustering method for using multilocus genotype data to infer population structure and assign individuals to populations, which can be applied to most of the commonly used genetic markers, provided that they are not closely linked.
Journal ArticleDOI
Inference of Population Structure Using Multilocus Genotype Data: Linked Loci and Correlated Allele Frequencies
TL;DR: Extensions to the method of Pritchard et al. for inferring population structure from multilocus genotype data are described and methods that allow for linkage between loci are developed, which allows identification of subtle population subdivisions that were not detectable using the existing method.
Journal ArticleDOI
A Human Genome Diversity Cell Line Panel
Howard M. Cann,Claudia de Toma,Lucien Cazes,Marie Fernande Legrand,Valérie Morel,Laurence Piouffre,J. G. Bodmer,Walter F. Bodmer,Batsheva Bonne-Tamir,Anne Cambon-Thomsen,Zhu Chen,Jiayou Chu,Carlo Carcassi,Licinio Contu,Ruofu Du,Laurent Excoffier,G. B. Ferrara,Jonathan S. Friedlaender,Helena Groot,David Gurwitz,Trefor Jenkins,Rene J. Herrera,Xiaoyi Huang,Judith R. Kidd,Kenneth K. Kidd,André Langaney,Alice A. Lin,S. Qasim Mehdi,Peter Parham,Alberto Piazza,Maria Pia Pistillo,Yaping Qian,Qunfang Shu,Jiujin Xu,Shi-Yao Zhu,James L. Weber,Henry T. Greely,Marcus W. Feldman,Gilles Thomas,Jean Dausset,Luigi Luca Cavalli-Sforza +40 more
TL;DR: A resource of 1064 cultured lymphoblastoid cell lines from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation Jean Dausset (CEPH) in Paris.
Journal ArticleDOI
Estimating African American admixture proportions by use of population-specific alleles.
Esteban J. Parra,Amy Marcini,Joshua M. Akey,Jeremy J. Martinson,Mark A. Batzer,Richard S. Cooper,Terrence Forrester,David B. Allison,Ranjan Deka,Robert E. Ferrell,Mark D. Shriver +10 more
TL;DR: Significant nonrandom association between two markers located 22 cM apart (FY-null and AT3) is detected, most likely due to admixture linkage disequilibrium created in the interbreeding of the two parental populations, emphasize the importance of admixed populations as a useful resource for mapping traits with different prevalence in two parental population.
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