Geographic Patterns of Genome Admixture in Latin American Mestizos
Sijia Wang,Nicolas Ray,Winston Rojas,María Victoria Parra,Gabriel Bedoya,Carla Gallo,Giovanni Poletti,Guido Mazzotti,Kim Hill,A. M. Hurtado,Beatriz Camrena,Humberto Nicolini,William Klitz,Ramiro Barrantes,Julio Molina,Nelson B. Freimer,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,José E. Dipierri,Emma L. Alfaro,Graciela Bailliet,Néstor O. Bianchi,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Andres Ruiz-Linares +28 more
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TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.Abstract:
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.read more
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Population structure and paternal admixture landscape on present‐day Mexican‐Mestizos revealed by Y‐STR haplotypes
Joel Salazar-Flores,R. Dondiego-Aldape,Rodrigo Rubi-Castellanos,M. Anaya-Palafox,Ismael Nuño-Arana,Luis Miguel Canseco-Ávila,G. Flores-Flores,M.E. Morales-Vallejo,N. Barojas-Pérez,J.F. Muñoz-Valle,R. Campos-Gutiérrez,Héctor Rangel-Villalobos +11 more
TL;DR: The population structure and paternal admixture of present‐day Mexican‐Mestizo populations based on Y‐STRs and SAMOVA test and Autocorrelation Index for DNA Analysis autocorrelogram plot suggested preferential gene flow of males with neighboring populations in agreement with the isolation‐by‐distance model.
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Geografía génica de Chile: Distribución regional de los aportes genéticos americanos, europeos y africanos
Macarena Fuentes,Iván Pulgar,Carla Gallo,Maria Cátira Bortolini,Samuel Canizales-Quinteros,Gabriel Bedoya,Rolando González-José,Andres Ruiz-Linares,Francisco Rothhammer,Francisco Rothhammer +9 more
TL;DR: In this article, the authors estimate the regional rate of American, European and African admixture of the Chilean population using Forty single nucleotide polymorphisms (SNP) which exhibit substantially different frequencies between Amerindian populations (ancestry-informative markers or AIM´s), were genotyped in a sample of 923 Chilean participants to estimate individual genetic ancestry.
Journal ArticleDOI
Prevalence of Celiac Disease in Latin America: A Systematic Review and Meta-Regression
Rafael Parra-Medina,Nicolás Molano-González,Adriana Rojas-Villarraga,Nancy Agmon-Levin,Maria Teresa Arango,Yehuda Shoenfeld,Juan-Manuel Anaya +6 more
TL;DR: Although CD seems to be a rare condition in Colombians; the general prevalence of the disease in Latin Americans seemingly corresponds to a similar scenario observed in Europeans.
Journal ArticleDOI
Reconstructing the Population History of Nicaragua by Means of mtDNA, Y-Chromosome STRs, and Autosomal STR Markers
Carolina Núñez,Miriam Baeta,Cecilia Sosa,Yolanda Casalod,Jianye Ge,Bruce Budowle,Begoña Martínez-Jarreta +6 more
TL;DR: The study reveals that the Nicaraguan Mestizo population harbors a high proportion of European male and Native American female substrate, and the amount of African ancestry is also interesting, probably because of the contribution of Spanish conquerors with North African genetic traces or that of West African slaves.
Journal ArticleDOI
The Human Microbiota as a Marker for Migrations of Individuals and Populations
TL;DR: Evidence that the microbes that constitute the human microbiota coevolved with humans and maintain complex community and host interactions is discussed and whether a wider approach to the study of human ancestry based on the human microbiome is now possible is examined.
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