Geographic Patterns of Genome Admixture in Latin American Mestizos
Sijia Wang,Nicolas Ray,Winston Rojas,María Victoria Parra,Gabriel Bedoya,Carla Gallo,Giovanni Poletti,Guido Mazzotti,Kim Hill,A. M. Hurtado,Beatriz Camrena,Humberto Nicolini,William Klitz,Ramiro Barrantes,Julio Molina,Nelson B. Freimer,Maria Cátira Bortolini,Francisco M. Salzano,Maria Luiza Petzl-Erler,Luiza T. Tsuneto,José E. Dipierri,Emma L. Alfaro,Graciela Bailliet,Néstor O. Bianchi,Elena Llop,Francisco Rothhammer,Francisco Rothhammer,Laurent Excoffier,Andres Ruiz-Linares +28 more
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TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women.Abstract:
The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.read more
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Reconstructing the population genetic history of the Caribbean.
Andrés Moreno-Estrada,Simon Gravel,Simon Gravel,Fouad Zakharia,Jacob L. McCauley,Jake K. Byrnes,Christopher R. Gignoux,Patricia Ortiz-Tello,Ricardo Martinez,Dale J. Hedges,Richard W Morris,Celeste Eng,Karla Sandoval,Suehelay Acevedo-Acevedo,Paul Norman,Zulay Layrisse,Peter Parham,Juan Carlos Martínez-Cruzado,Esteban G. Burchard,Michael L. Cuccaro,Eden R. Martin,Carlos Bustamante +21 more
TL;DR: It is demonstrated that the ancestral components in admixed genomes can be traced back to distinct sub-continental source populations with far greater resolution than previously thought, even when limited pre-Columbian Caribbean haplotypes have survived.
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The X chromosome and sex-specific effects in infectious disease susceptibility
Haiko Schurz,Haiko Schurz,Muneeb Salie,Gerard Tromp,Gerard Tromp,Eileen G. Hoal,Craig J. Kinnear,Marlo Möller +7 more
TL;DR: The involvement of the X chromosome and X inactivation in immunity is discussed and its role in sexual dimorphism of infectious diseases using tuberculosis susceptibility as an example, in which male sex bias is clear, yet not fully explored is addressed.
Journal ArticleDOI
Development of a Panel of Genome-Wide Ancestry Informative Markers to Study Admixture Throughout the Americas
Joshua Galanter,Juan Carlos Fernández-López,Christopher R. Gignoux,Jill S. Barnholtz-Sloan,Ceres Fernandez-Rozadilla,Marc Via,Alfredo Hidalgo-Miranda,Alejandra V. Contreras,Laura Uribe Figueroa,Paola Raska,Gerardo Jimenez-Sanchez,Irma Silva Zolezzi,María Dolores Torres,Clara Ruiz–Ponte,Y. Ruiz,Antonio Salas,Elizabeth A. Nguyen,Celeste Eng,Lisbeth Borjas,William Zabala,William Zabala,Guillermo Barreto,Fernando Rondóo González,A. Ibarra,Patricia Taboada,L. Porras,L. Porras,F.L. Moreno,Abigail W. Bigham,Gerardo Gutiérrez,Tom D. Brutsaert,Fabiola León-Velarde,Lorna G. Moore,Enrique Vargas,Miguel Cruz,Jorge Escobedo,Jose R. Rodriguez-Santana,William Rodriguez-Cintron,Rocio Chapela,Jean G. Ford,Carlos Bustamante,Daniela Seminara,Mark D. Shriver,Elad Ziv,Esteban G. Burchard,Robert W. Haile,Esteban J. Parra,Angel Carracedo +47 more
TL;DR: A panel of 446 ancestry informative markers (AIMs) optimized to estimate ancestral proportions in individuals and populations throughout Latin America will be useful resources to explore population history of admixture in Latin America and to correct for the potential effects of population stratification in admixed samples in the region.
Journal ArticleDOI
Human and Helicobacter pylori coevolution shapes the risk of gastric disease.
Nuri Kodaman,Alvaro Pazos,Barbara G. Schneider,M. Blanca Piazuelo,Robertino M. Mera,Rafal S. Sobota,Liviu A. Sicinschi,Carrie L. Shaffer,Judith Romero-Gallo,Thibaut de Sablet,Reed Harder,Luis Eduardo Bravo,Richard M. Peek,Keith T. Wilson,Timothy L. Cover,Scott M. Williams,Pelayo Correa +16 more
TL;DR: It is concluded that coevolutionary relationships are important determinants of gastric disease risk and that the historical colonization of the Americas continues to influence health in modern American populations.
Journal ArticleDOI
Genomic Insights into the Ancestry and Demographic History of South America
Julian R. Homburger,Andrés Moreno-Estrada,Andrés Moreno-Estrada,Christopher R. Gignoux,Dominic Nelson,Elena Sánchez,Patricia Ortiz-Tello,Bernardo A. Pons-Estel,Eduardo Acevedo-Vásquez,Pedro Miranda,Carl D. Langefeld,Simon Gravel,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Carlos Bustamante +14 more
TL;DR: A strong gradient in the Native American ancestry component of South American Latinos associated with country of origin and the geography of local indigenous populations is found, which can impact the understanding of population-level differences in biomedical traits and, thus, inform future medical genetic studies in the region.
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